Fchsd2 MGI Mouse Gene Detail - MGI:2448475 - FCH and double SH3 domains 2

Symbol

Fchsd2
Name

FCH and double SH3 domains 2
Synonyms

mKIAA0769, Sh3md3

Feature Type

protein coding gene
IDs

MGI:2448475
NCBI Gene: 207278
Gene Overview

MyGene.info: FCHSD2
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:101108499-101284405 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.50 cM
Mapping Data

2 experiments

SNPs within 2kb

720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448475	protein coding gene	Chr7:101092863-101284405 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032581	protein coding gene	Chr7:104057394-104243309 (+)
A/J	MGP_AJ_G0032555	protein coding gene	Chr7:101402675-101582804 (+)
AKR/J	MGP_AKRJ_G0032491	protein coding gene	Chr7:103815503-104000759 (+)
BALB/cJ	MGP_BALBcJ_G0032566	protein coding gene	Chr7:101092054-101271868 (+)
C3H/HeJ	MGP_C3HHeJ_G0032281	protein coding gene	Chr7:104219644-104403706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033064	protein coding gene	Chr7:107995307-108177819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030058	protein coding gene	Chr7:103788730-103958477 (+)
CAST/EiJ	MGP_CASTEiJ_G0031608	protein coding gene	Chr7:95773011-95951987 (+)
CBA/J	MGP_CBAJ_G0032248	protein coding gene	Chr7:111719528-111918982 (+)
DBA/2J	MGP_DBA2J_G0032399	protein coding gene	Chr7:99757748-99936121 (+)
FVB/NJ	MGP_FVBNJ_G0032356	protein coding gene	Chr7:99517362-99705831 (+)
LP/J	MGP_LPJ_G0032489	protein coding gene	Chr7:105385141-105567523 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032389	protein coding gene	Chr7:113071571-113285468 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033086	protein coding gene	Chr7:103100609-103284015 (+)
PWK/PhJ	MGP_PWKPhJ_G0031326	protein coding gene	Chr7:92874271-93056648 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031169	protein coding gene	Chr7:90397937-90582889 (+)
WSB/EiJ	MGP_WSBEiJ_G0031725	protein coding gene	Chr7:103801091-103994238 (+)

Human Ortholog

FCHSD2, FCH and double SH3 domains 2

Vertebrate Orthologs

11

Human Ortholog

FCHSD2, FCH and double SH3 domains 2
Orthology source: HomoloGene, HGNC
Synonyms

NWK, NWK1, SH3MD3
Links

HGNC:29114

NCBI Gene ID: 9873

neXtProt AC: NX_O94868

UniProt: O94868
Chr Location

11q13.4; chr11:72836743-73142682 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8887
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FCHSD2
Gene Tree

Fchsd2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Fchsd2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

21
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

651
Tissues

2
cDNA Data

117
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fchsd2

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Fchsd2 interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

64
RefSeq

12
UniProt

3
CCDS

CCDS52327.1, CCDS52328.1
UniGene

263041

Ensembl

ENSMUSG00000030691 (Evidence)
NCBI Gene

207278

			Length	Strain/Species	Flank
genomic	207278	NCBI Gene Model \| MGI Sequence Detail	175907	C57BL/6J	± kb
transcript	NM_199012	RefSeq \| MGI Sequence Detail	4432	C57BL/6
polypeptide	Q3USJ8	UniProt \| EBI \| MGI Sequence Detail	740	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030866 F-BAR and double SH3 domains protein 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR034934 F-BAR and double SH3 domains protein 2

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035556 FCHSD2, SH3 domain 2

IPR035460 FCHSD, SH3 domain 1

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 117

cDNA 117

Microarray probesets 3

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MGI:2142383

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 15
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:283192 Cao H, et al., FCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro. PLoS One. 2013;8(2):e56516

TSS for Fchsd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68187	Chr7:101092828-101092859 (+)	-15,655 bp
Tssr68188	Chr7:101092875-101092882 (+)	-15,620 bp
Tssr68189	Chr7:101108464-101108503 (+)	-15 bp
Tssr68190	Chr7:101108519-101108546 (+)	34 bp
Tssr68191	Chr7:101108548-101108579 (+)	65 bp
Tssr68192	Chr7:101108600-101108642 (+)	122 bp
Tssr68193	Chr7:101108740-101108753 (+)	248 bp
Tssr68194	Chr7:101108768-101108783 (+)	277 bp
Tssr68195	Chr7:101108788-101108811 (+)	301 bp
Tssr68196	Chr7:101109313-101109323 (+)	819 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16