Fchsd2 MGI Mouse Gene Detail - MGI:2448475 - FCH and double SH3 domains 2

Symbol

Fchsd2
Name

FCH and double SH3 domains 2
Synonyms

mKIAA0769, Sh3md3

Feature Type

protein coding gene
IDs

MGI:2448475
NCBI Gene: 207278
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr7:100757836-100933613 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.50 cM
Mapping Data

2 experiments

SNPs within 2kb

4325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448475	protein coding gene	Chr7:100742070-100933613 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032581	protein coding gene	Chr7:104057394-104243309 (+)
A/J	MGP_AJ_G0032555	protein coding gene	Chr7:101402675-101582804 (+)
AKR/J	MGP_AKRJ_G0032491	protein coding gene	Chr7:103815503-104000759 (+)
BALB/cJ	MGP_BALBcJ_G0032566	protein coding gene	Chr7:101092054-101271868 (+)
C3H/HeJ	MGP_C3HHeJ_G0032281	protein coding gene	Chr7:104219644-104403706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033064	protein coding gene	Chr7:107995307-108177819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030058	protein coding gene	Chr7:103788730-103958477 (+)
CAST/EiJ	MGP_CASTEiJ_G0031608	protein coding gene	Chr7:95773011-95951987 (+)
CBA/J	MGP_CBAJ_G0032248	protein coding gene	Chr7:111719528-111918982 (+)
DBA/2J	MGP_DBA2J_G0032399	protein coding gene	Chr7:99757748-99936121 (+)
FVB/NJ	MGP_FVBNJ_G0032356	protein coding gene	Chr7:99517362-99705831 (+)
LP/J	MGP_LPJ_G0032489	protein coding gene	Chr7:105385141-105567523 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032389	protein coding gene	Chr7:113071571-113285468 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033086	protein coding gene	Chr7:103100609-103284015 (+)
PWK/PhJ	MGP_PWKPhJ_G0031326	protein coding gene	Chr7:92874271-93056648 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031169	protein coding gene	Chr7:90397937-90582889 (+)
WSB/EiJ	MGP_WSBEiJ_G0031725	protein coding gene	Chr7:103801091-103994238 (+)

Human Ortholog

FCHSD2, FCH and double SH3 domains 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCHSD2, FCH and double SH3 domains 2
Synonyms

NWK, NWK1, SH3MD3
Links

HGNC:29114

NCBI Gene ID: 9873

UniProt: O94868
Chr Location

11q13.4; chr11:72836745-73142318 (-) GRCh38

MGI Vertebrate Homology

Fchsd2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FCHSD2
Gene Tree

Fchsd2

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Phenotype Summary

16 phenotype references

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Fchsd2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

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All GO Annotations

42
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

4
cDNA Data

117
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fchsd2

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All Sequences

64
RefSeq

12
UniProt

3
CCDS

CCDS52327.1, CCDS52328.1

Ensembl

ENSMUSG00000030691 (Evidence)
NCBI Gene

207278

			Length	Strain/Species	Flank
genomic	207278	NCBI Gene Model \| MGI Sequence Detail	175778	C57BL/6J	± kb
transcript	NM_199012	RefSeq \| MGI Sequence Detail	4376	C57BL/6
polypeptide	Q3USJ8	UniProt \| EBI \| MGI Sequence Detail	740	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030866 F-BAR and double SH3 domains protein 2

(term hierarchy)
PDB

7WEG
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR034934 F-BAR and double SH3 domains protein 2, F-BAR domain

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035556 FCHSD2, SH3 domain 2

IPR035460 FCHSD, SH3 domain 1

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q3USJ8 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 117

cDNA 117

Microarray probesets 3

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MGI:2142383

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 16
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fchsd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68189	Chr7:100757671-100757710 (+)	-145 bp
Tssr68190	Chr7:100757726-100757753 (+)	-96 bp
Tssr68191	Chr7:100757755-100757786 (+)	-65 bp
Tssr68192	Chr7:100757807-100757849 (+)	-8 bp
Tssr68193	Chr7:100757947-100757960 (+)	118 bp
Tssr68194	Chr7:100757975-100757990 (+)	147 bp
Tssr68195	Chr7:100757995-100758018 (+)	171 bp
Tssr68196	Chr7:100758520-100758530 (+)	689 bp
Tssr68197	Chr7:100759942-100759954 (+)	2,112 bp
Tssr2350	Chr7:100793704-100793709 (+)	35,871 bp
Tssr68198	Chr7:100797353-100797378 (+)	39,530 bp
Tssr68199	Chr7:100812236-100812244 (+)	54,404 bp
Tssr68200	Chr7:100813402-100813407 (+)	55,569 bp
Tssr68201	Chr7:100850375-100850380 (+)	92,542 bp
Tssr68202	Chr7:100854602-100854614 (+)	96,772 bp
Tssr68203	Chr7:100863428-100863438 (+)	105,597 bp
Tssr68204	Chr7:100868489-100868524 (+)	110,671 bp
Tssr68205	Chr7:100872968-100872978 (+)	115,137 bp
Tssr68206	Chr7:100890263-100890268 (+)	132,430 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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