Fchsd2 Gene Detail

Summary

• Symbol
  Fchsd2
• Name
  FCH and double SH3 domains 2
• Synonyms
  mKIAA0769, Sh3md3

• Feature Type
  protein coding gene
• IDs
  MGI:2448475
  NCBI Gene: 207278
• Gene Overview
  MyGene.info: FCHSD2
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr7:101092863-101284405 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    191543 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 54.50 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  FCHSD2, FCH and double SH3 domains 2

• Vertebrate Orthologs
  11

• Human Ortholog
  FCHSD2, FCH and double SH3 domains 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  NWK, SH3MD3
• Links
  HGNC:29114

  NCBI Gene ID: 9873

  neXtProt AC: NX_O94868

  UniProt: O94868

  
  
• Chr Location
  11q13.4; chr11:72836743-73142682 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 8887
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: FCHSD2
• Gene Tree
  Fchsd2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotype references
  

• All Mutations and Alleles
  10
• Chemically induced (other)
  1
• Gene trapped
  6
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Fchsd2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  23 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  1

• External Resources
  FuncBase

Expression

• Assay Results
  20
• Tissues
  2
• cDNA Data
  116
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fchsd2

Interactions

• Fchsd2 interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  57
• RefSeq
  8
• UniProt
  3
• CCDS
  CCDS52327.1, CCDS52328.1
• UniGene
  263041

• VEGA
  OTTMUSG00000025163 (Evidence)
• Ensembl
  ENSMUSG00000030691 (Evidence)
• NCBI Gene
  207278

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000025163	VEGA Gene Model | MGI Sequence Detail	191543	C57BL/6J
transcript	OTTMUST00000061906	VEGA | MGI Sequence Detail	4453	Not Applicable
polypeptide	OTTMUSP00000030460	VEGA | MGI Sequence Detail	764	Not Applicable

Polymorphisms

• SNPs within 2kb
  868 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR027267 AH/BAR domain superfamily
  IPR034936 F-BAR and double SH3 domains protein
  IPR034934 F-BAR and double SH3 domains protein 2
  IPR031160 F-BAR domain
  IPR001060 FCH domain
  IPR035556 FCHSD2, SH3 domain 2
  IPR035460 FCHSD, SH3 domain 1
  IPR001452 SH3 domain
  IPR036028 SH3-like domain superfamily

Molecular
Reagents

• All nucleic 116

  cDNA 116

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2142383

References

• Summaries
  All 36

  Developmental Gene Expression 2

  Gene Ontology 1

  Phenotypes 13
• Earliest
  J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582