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H2bc8 Gene Detail
Summary
  • Symbol
    H2bc8
  • Name
    H2B clustered histone 8
  • Synonyms
    Hist1h2bg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448386
    NCBI Gene: 319181
  • Member of
    Hist1 cluster
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23755574-23756037 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 9.80 cM, cytoband A2-A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448386
protein coding gene Chr13:23755570-23756187 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020356
protein coding gene Chr13:21117664-21126411 (+)
A/J MGP_AJ_G0020250
protein coding gene Chr13:18607504-18613066 (+)
AKR/J MGP_AKRJ_G0020280
protein coding gene Chr13:20863661-20864195 (+)
BALB/cJ MGP_BALBcJ_G0020296
protein coding gene Chr13:20601023-20602424 (+)
C3H/HeJ MGP_C3HHeJ_G0020038
protein coding gene Chr13:18979339-18979749 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018323
protein coding gene Chr13:19412741-19413263 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0020002
protein coding gene Chr13:20336761-20338077 (-)
DBA/2J MGP_DBA2J_G0020126
protein coding gene Chr13:18246015-18246507 (+)
FVB/NJ MGP_FVBNJ_G0020166
protein coding gene Chr13:19800013-19801732 (+)
LP/J MGP_LPJ_G0020261
protein coding gene Chr13:21428809-21438431 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020195
protein coding gene Chr13:22915071-22916251 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020771
protein coding gene Chr13:20714666-20715145 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0019190
protein coding gene Chr13:19511328-19514249 (+)
WSB/EiJ MGP_WSBEiJ_G0019679
protein coding gene Chr13:20851110-20852449 (+)



Homology
more
  • Human Ortholog
    H2BC4, H2B clustered histone 4
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2BC4, H2B clustered histone 4
  • Synonyms
    dJ221C16.3, H2B.1, H2BC10, H2BC6, H2BC7, H2BC8, H2BFL, H2B/l, HIST1H2BC
  • Links
    NCBI Gene ID: 8347
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26086317-26123926 (-)  GRCh38

  • Human Ortholog
    H2BC5, H2B clustered histone 5
  • Synonyms
    dJ221C16.6, H2B.1B, H2B/a, H2B/b, H2BFA, H2BFB, H2BFG, H2BFH, H2BFK, H2BFL, H2B/g, H2B/h, H2B/k, H2B/l, HIRIP2, HIST1H2BC, HIST1H2BD, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI
  • Links
    NCBI Gene ID: 3017
    neXtProt AC: NX_P58876, NX_P62807
    UniProt: P58876

  • Chr Location
    6p22.2; chr6:26158121-26171349 (+)  GRCh38

  • Human Ortholog
    H2BC6, H2B clustered histone 6
  • Synonyms
    dJ221C16.8, H2BC10, H2BC4, H2BC7, H2BC8, H2BFH, H2B/h, H2B.h, HIST1H2BE
  • Links
    NCBI Gene ID: 8344
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26172059-26184655 (+)  GRCh38

  • Human Ortholog
    H2BC8, H2B clustered histone 8
  • Synonyms
    dJ221C16.8, H2B.1A, H2B/a, H2BC10, H2BC4, H2BC6, H2BC7, H2BFA, HIST1H2BG
  • Links
    NCBI Gene ID: 8339
    neXtProt AC: NX_P62807
    UniProt: P62807

  • Chr Location
    6p22.2; chr6:26216200-26216688 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving H2bc8
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 319181 NCBI Gene Model | MGI Sequence Detail 464 C57BL/6J ±  kb
transcript NM_178196 RefSeq | MGI Sequence Detail 464 C57BL/6  
polypeptide NP_835503 RefSeq | MGI Sequence Detail 126 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory