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Lrrc10 Gene Detail
Summary
  • Symbol
    Lrrc10
  • Name
    leucine rich repeat containing 10
  • Synonyms
    D330003I11Rik, Hrlrrp, Serdin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448063
    NCBI Gene: 237560
Location & Maps
more
  • Sequence Map
    Chr10:117045341-117046768 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1428 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRRC10, leucine rich repeat containing 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LRRC10, leucine rich repeat containing 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HRLRRP, LRRC10A
  • Links
    NCBI Gene ID: 376132
    neXtProt AC: NX_Q5BKY1

  • Chr Location
    12q15; chr12:69608564-69611162 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lrrc10
  • Incidental Mutations
Mice homozygous for a null mutation are viable and fertile and do not display any gross abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 237560 NCBI Gene Model | MGI Sequence Detail 1428 C57BL/6J ±  kb
transcript NM_146242 RefSeq | MGI Sequence Detail 1428 C57BL/6  
polypeptide Q8K3W2 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009931 leucine-rich repeat-containing protein 10
  • InterPro Domains
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2442066
References
more
  • Summaries
    All 21
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:195548 Brody MJ, et al., Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory