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Dennd1b Gene Detail
Summary
  • Symbol
    Dennd1b
  • Name
    DENN/MADD domain containing 1B
  • Synonyms
    4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447812
    NCBI Gene: 329260
  • Gene Overview
    MyGene.info: DENND1B
Location & Maps
more
  • Sequence Map
    Chr1:138963435-139178960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      215526 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.84 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DENND1B, DENN domain containing 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DENND1B, DENN domain containing 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1ORF18, C1orf218, FAM31B
  • Links
    NCBI Gene ID: 163486
    neXtProt AC: NX_Q6P3S1

  • Chr Location
    1q31.3; chr1:197504748-197782175 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Dennd1b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033401 VEGA Gene Model | MGI Sequence Detail 215526 C57BL/6J ±  kb
transcript OTTMUST00000083856 VEGA | MGI Sequence Detail 8073 Not Applicable  
polypeptide OTTMUSP00000045118 VEGA | MGI Sequence Detail 691 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    986 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
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MGI:1922993, MGI:1924310, MGI:2443969, MGI:2670998
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229307 Yang CW, et al., Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease. Cell. 2016 Jan 14;164(1-2):141-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory