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Dennd1b Gene Detail
Summary
  • Symbol
    Dennd1b
  • Name
    DENN/MADD domain containing 1B
  • Synonyms
    4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447812
    NCBI Gene: 329260
  • Gene Overview
    MyGene.info: DENND1B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:138963709-139176043 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    970 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447812
protein coding gene Chr1:138963435-139178960 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016550
protein coding gene Chr1:143004022-143229555 (+)
A/J MGP_AJ_G0016533
protein coding gene Chr1:137449110-137663246 (+)
AKR/J MGP_AKRJ_G0016498
protein coding gene Chr1:141602778-141820194 (+)
BALB/cJ MGP_BALBcJ_G0016493
protein coding gene Chr1:137805117-138018573 (+)
C3H/HeJ MGP_C3HHeJ_G0016319
protein coding gene Chr1:141694820-141906848 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016954
protein coding gene Chr1:148018825-148257734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014665
protein coding gene Chr1:130513880-130726628 (+)
CAST/EiJ MGP_CASTEiJ_G0015899
protein coding gene Chr1:140846535-141074779 (+)
CBA/J MGP_CBAJ_G0016292
protein coding gene Chr1:153126572-153359652 (+)
DBA/2J MGP_DBA2J_G0016398
protein coding gene Chr1:136459035-136674147 (+)
FVB/NJ MGP_FVBNJ_G0016397
protein coding gene Chr1:135093262-135301703 (+)
LP/J MGP_LPJ_G0016469
protein coding gene Chr1:144105604-144327093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016422
protein coding gene Chr1:158789351-159021766 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016990
protein coding gene Chr1:141380003-141613053 (+)
PWK/PhJ MGP_PWKPhJ_G0015685
protein coding gene Chr1:135532724-135742700 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015472
protein coding gene Chr1:140336478-140563662 (+)
WSB/EiJ MGP_WSBEiJ_G0015962
protein coding gene Chr1:141394615-141617724 (+)



Homology
more
  • Human Ortholog
    DENND1B, DENN domain containing 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DENND1B, DENN domain containing 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1ORF18, C1orf218, FAM31B
  • Links
    NCBI Gene ID: 163486
    neXtProt AC: NX_Q6P3S1
    UniProt: Q6P3S1

  • Chr Location
    1q31.3; chr1:197504748-197782138 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO results in enhanced allergic responses to aerosolized antigen challenges caused by delayed TCR down-modulation following receptor activation in T helper 2 cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329260 NCBI Gene Model | MGI Sequence Detail 212335 C57BL/6J ±  kb
transcript NM_001166501 RefSeq | MGI Sequence Detail 8206 C57BL/6  
polypeptide Q3U1T9 UniProt | EBI | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
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MGI:1922993, MGI:1924310, MGI:2443969, MGI:2670998
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:229307 Yang CW, et al., Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease. Cell. 2016 Jan 14;164(1-2):141-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory