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Nat8l Gene Detail
Summary
  • Symbol
    Nat8l
  • Name
    N-acetyltransferase 8-like
  • Synonyms
    1110038O08Rik, Shati
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447776
    NCBI Gene: 269642
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:33995984-34005916 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9933 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NAT8L, N-acetyltransferase 8 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NAT8L, N-acetyltransferase 8 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CML3, NACED, NAT8-LIKE
  • Links
    NCBI Gene ID: 339983
    neXtProt AC: NX_Q8N9F0
    UniProt: Q8N9F0

  • Chr Location
    4p16.3; chr4:2059512-2069089 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    9 involving Nat8l
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    9 strains or lines available
Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    11
  • Tissues
    9
  • cDNA Data
    29
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055711 VEGA Gene Model | MGI Sequence Detail 9933 C57BL/6J ±  kb
transcript OTTMUST00000137856 VEGA | MGI Sequence Detail 6529 Not Applicable  
polypeptide OTTMUSP00000072546 VEGA | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    36 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916012
References
more
  • Summaries
    All 64
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:255312 von Jonquieres G, et al., Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy. Acta Neuropathol. 2018 Jan;135(1):95-113
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory