Nat8l
Gene Detail

Symbol

Name
ID

Nat8l
N-acetyltransferase 8-like
MGI:2447776

Synonyms

1110038O08Rik, Shati

Feature Type

protein coding gene

Genetic Map

Chromosome 5
17.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:33995984-34005916 bp, + strand From NCBI annotation of GRCm38   9933 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:19546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nat8l

Human
homologs

Human Homolog		NAT8L, N-acetyltransferase 8-like (GCN5-related, putative)
NCBI Gene ID		339983
neXtProt AC		NX_Q8N9F0
Human Synonyms		CML3, NACED, NAT8-LIKE
Human Chr (Location)		4p16.3; chr4:2059512-2069089 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human NAT8L

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Chemically induced (ENU)(1) Radiation induced(6) Targeted(4)
Genomic Mutations involving Nat8l (7)
Incidental mutations (data from APF )
 

Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.

 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)

Interactions

Nat8l interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	metabolic process, positive regulation of dopamine uptake involved in synaptic transmission
Component	cytoplasm, endoplasmic reticulum, ...
Function	aspartate N-acetyltransferase activity, N-acetyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (11)    Tissues (9)    Images (18)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	11

cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(30) cDNA(30)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000048142 (Evidence)
Entrez Gene	269642 (Evidence)
UniGene	274610
DFCI	TC1651491, TC1600855, TC1577499
DoTS	DT.488120, DT.60105126
NIA Mouse Gene Index	U042630
EC	2.3.1.17
Consensus CDS Project	CCDS19210.1
International Mouse Knockout Project Status	Nat8l

Sequences

Length	Strain/Species
genomic	269642	NCBI Gene Model | MGI Sequence Detail	9933	C57BL/6J
transcript	NM_001001985	RefSeq | MGI Sequence Detail	6529	C57BL/6
polypeptide	Q3UGX3	UniProt | EBI | MGI Sequence Detail	299	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(36 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR000182	GNAT domain
Protein Ontology	PR:000011004	N-acetylaspartate synthetase

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207207 Pessentheiner AR, et al., NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes. J Biol Chem. 2013 Dec 13;288(50):36040-51
All references(41)

Other
accession IDs

MGI:1916012