Nat8l MGI Mouse Gene Detail - MGI:2447776 - N-acetyltransferase 8-like

Symbol

Nat8l
Name

N-acetyltransferase 8-like
Synonyms

1110038O08Rik, Shati

Feature Type

protein coding gene
IDs

MGI:2447776
NCBI Gene: 269642
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr5:34153328-34163260 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.83 cM
Mapping Data

2 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447776	protein coding gene	Chr5:34153328-34163260 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029457	protein coding gene	Chr5:32198529-32208461 (+)
A/J	MGP_AJ_G0029424	protein coding gene	Chr5:31147487-31157421 (+)
AKR/J	MGP_AKRJ_G0029373	protein coding gene	Chr5:32350221-32360152 (+)
BALB/cJ	MGP_BALBcJ_G0029434	protein coding gene	Chr5:31675652-31685586 (+)
C3H/HeJ	MGP_C3HHeJ_G0029156	protein coding gene	Chr5:32384704-32394638 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029888	protein coding gene	Chr5:34085302-34095234 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027125	protein coding gene	Chr5:28945334-28954651 (+)
CAST/EiJ	MGP_CASTEiJ_G0028565	protein coding gene	Chr5:31462099-31472275 (+)
CBA/J	MGP_CBAJ_G0029124	protein coding gene	Chr5:34817524-34827491 (+)
DBA/2J	MGP_DBA2J_G0029272	protein coding gene	Chr5:31328865-31338796 (+)
FVB/NJ	MGP_FVBNJ_G0029231	protein coding gene	Chr5:30756852-30766786 (+)
LP/J	MGP_LPJ_G0029357	protein coding gene	Chr5:32622187-32632153 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029261	protein coding gene	Chr5:35687590-35697521 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029921	protein coding gene	Chr5:31867575-31877507 (+)
PWK/PhJ	MGP_PWKPhJ_G0028290	protein coding gene	Chr5:30460675-30470624 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028121	protein coding gene	Chr5:31317996-31327995 (+)
WSB/EiJ	MGP_WSBEiJ_G0028646	protein coding gene	Chr5:31935698-31945629 (+)

Human Ortholog

NAT8L, N-acetyltransferase 8 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAT8L, N-acetyltransferase 8 like
Synonyms

CML3, NACED, NAT8-LIKE
Links

HGNC:26742

NCBI Gene ID: 339983

UniProt: Q8N9F0
Chr Location

4p16.3; chr4:2059327-2069089 (+) GRCh38

MGI Vertebrate Homology

Nat8l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAT8L
Gene Tree

Nat8l

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotypes from multigenic genotypes
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

5
Spontaneous

1
Targeted

6
Genomic Mutations

9 involving Nat8l
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.

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All GO Annotations

31
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

22
cDNA Data

30
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nat8l

ZFIN nat8l

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS19210.1

Ensembl

ENSMUSG00000048142 (Evidence)
NCBI Gene

269642

			Length	Strain/Species	Flank
genomic	269642	NCBI Gene Model \| MGI Sequence Detail	9933	C57BL/6J	± kb
transcript	NM_001001985	RefSeq \| MGI Sequence Detail	6529	C57BL/6
polypeptide	Q3UGX3	UniProt \| EBI \| MGI Sequence Detail	299	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011004 N-acetylaspartate synthetase

(term hierarchy)
EC

2.3.1.17
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR050769 Camello N-acetyltransferase

IPR000182 GNAT domain

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All nucleic 35

cDNA 31

Primer pair 4

Microarray probesets 4

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MGI:1916012

Summaries

All 82

Developmental Gene Expression 4

Diseases 1

Gene Ontology 16

Phenotypes 40
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:360187 Li Y, et al., Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite. Cancer Cell. 2024 Jun 10;42(6):985-1002.e18

TSS for Nat8l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45846	Chr5:34153353-34153374 (+)	36 bp
Tssr45847	Chr5:34153392-34153405 (+)	71 bp
Tssr45848	Chr5:34153438-34153455 (+)	119 bp
Tssr45849	Chr5:34153463-34153481 (+)	144 bp
Tssr45850	Chr5:34153754-34153768 (+)	433 bp
Tssr45851	Chr5:34153929-34153938 (+)	606 bp
Tssr45852	Chr5:34153953-34153976 (+)	637 bp
Tssr45853	Chr5:34153983-34154034 (+)	681 bp
Tssr45854	Chr5:34154042-34154073 (+)	730 bp
Tssr45855	Chr5:34154075-34154089 (+)	754 bp
Tssr45856	Chr5:34154092-34154107 (+)	772 bp
Tssr45857	Chr5:34154114-34154125 (+)	792 bp
Tssr1458	Chr5:34154127-34154134 (+)	803 bp
Tssr1459	Chr5:34158267-34158289 (+)	4,950 bp
Tssr1460	Chr5:34158481-34158511 (+)	5,168 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24