Nat8l MGI Mouse Gene Detail - MGI:2447776 - N-acetyltransferase 8-like

Nat8l Gene Detail

Symbol

Nat8l
Name

N-acetyltransferase 8-like
Synonyms

1110038O08Rik, Shati

Feature Type

protein coding gene
IDs

MGI:2447776
NCBI Gene: 269642

Sequence Map

Chr5:33995984-34005916 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

9933 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.83 cM
Mapping Data

2 experiments

Human Ortholog

NAT8L, N-acetyltransferase 8 like

Vertebrate Orthologs

7

Human Ortholog

NAT8L, N-acetyltransferase 8 like
Orthology source: HomoloGene, HGNC
Synonyms

CML3, NACED, NAT8-LIKE
Links

HGNC:26742

NCBI Gene ID: 339983

neXtProt AC: NX_Q8N9F0
Chr Location

4p16.3; chr4:2059512-2069089 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 19546
1 human;1 mouse;1 rat;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NAT8L
Gene Tree

Nat8l

Diseases

1 with human NAT8L associations

				Human Disease	Mouse Models
				N-Acetylaspartate Deficiency; NACED OMIM: 614063

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Chemically induced (other)

2
Radiation induced

6
Spontaneous

1
Targeted

6
Genomic Mutations

10 involving Nat8l
Incidental Mutations

APF

Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.

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All GO Annotations

16
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

11
Tissues

9
cDNA Data

29
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase nat8l

ZFIN nat8l

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Nat8l interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

23
RefSeq

2
UniProt

2
CCDS

CCDS19210.1
UniGene

274610

			Length	Strain/Species	Flank
genomic	OTTMUSG00000055711	VEGA Gene Model \| MGI Sequence Detail	9933	C57BL/6J	± kb
transcript	OTTMUST00000137856	VEGA \| MGI Sequence Detail	6529	Not Applicable
polypeptide	OTTMUSP00000072546	VEGA \| MGI Sequence Detail	299	Not Applicable

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SNPs within 2kb

36 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000011004 N-acetylaspartate synthetase
EC

2.3.1.17
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000182 GNAT domain

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All nucleic 30

cDNA 30

Microarray probesets 4

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MGI:1916012

Summaries

All 40

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:227684 Toriumi K, et al., Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate. Eur Neuropsychopharmacol. 2015 Nov;25(11):2108-17

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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