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Nat8l Gene Detail
Summary
  • Symbol
    Nat8l
  • Name
    N-acetyltransferase 8-like
  • Synonyms
    1110038O08Rik, Shati
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447776
    NCBI Gene: 269642
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33995984-34005916 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447776
 protein coding gene Chr5:33995984-34005916 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029457
 protein coding gene Chr5:32198529-32208461 (+)
A/J MGP_AJ_G0029424
 protein coding gene Chr5:31147487-31157421 (+)
AKR/J MGP_AKRJ_G0029373
 protein coding gene Chr5:32350221-32360152 (+)
BALB/cJ MGP_BALBcJ_G0029434
 protein coding gene Chr5:31675652-31685586 (+)
C3H/HeJ MGP_C3HHeJ_G0029156
 protein coding gene Chr5:32384704-32394638 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029888
 protein coding gene Chr5:34085302-34095234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027125
 protein coding gene Chr5:28945334-28954651 (+)
CAST/EiJ MGP_CASTEiJ_G0028565
 protein coding gene Chr5:31462099-31472275 (+)
CBA/J MGP_CBAJ_G0029124
 protein coding gene Chr5:34817524-34827491 (+)
DBA/2J MGP_DBA2J_G0029272
 protein coding gene Chr5:31328865-31338796 (+)
FVB/NJ MGP_FVBNJ_G0029231
 protein coding gene Chr5:30756852-30766786 (+)
LP/J MGP_LPJ_G0029357
 protein coding gene Chr5:32622187-32632153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029261
 protein coding gene Chr5:35687590-35697521 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029921
 protein coding gene Chr5:31867575-31877507 (+)
PWK/PhJ MGP_PWKPhJ_G0028290
 protein coding gene Chr5:30460675-30470624 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028121
 protein coding gene Chr5:31317996-31327995 (+)
WSB/EiJ MGP_WSBEiJ_G0028646
 protein coding gene Chr5:31935698-31945629 (+)



Homology
more
  • Human Ortholog
    NAT8L, N-acetyltransferase 8 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NAT8L, N-acetyltransferase 8 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CML3, NACED, NAT8-LIKE
  • Links
    NCBI Gene ID: 339983
    neXtProt AC: NX_Q8N9F0
    UniProt: Q8N9F0

  • Chr Location
    4p16.3; chr4:2059512-2069089 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    10
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269642 NCBI Gene Model | MGI Sequence Detail 9933 C57BL/6J ±  kb
    transcript NM_001001985 RefSeq | MGI Sequence Detail 6529 C57BL/6  
    polypeptide Q3UGX3 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916012
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:255312 von Jonquieres G, et al., Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy. Acta Neuropathol. 2018 Jan;135(1):95-113
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    04/16/2019
    MGI 6.13     		The Jackson Laboratory