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Nat8l
Gene Detail
 Symbol
Name
ID
Nat8l
N-acetyltransferase 8-like
MGI:2447776
Synonyms 1110038O08Rik, Shati
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:33995984-34005916 bp, + strand
From NCBI annotation of GRCm38

  9933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19546  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nat8l

Human
homologs
Human Homolog NAT8L, N-acetyltransferase 8-like (GCN5-related, putative)
NCBI Gene ID 339983
neXtProt AC  NX_Q8N9F0
Human Synonyms  CML3, NACED, NAT8-LIKE
Human Chr (Location)  4p16.3; chr4:2059512-2069089 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NAT8L
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Radiation induced(5) Targeted(4)
Genomic Mutations involving Nat8l (6)
Incidental mutations (data from APF )
 
Mice homozygous for a null mutation display abnormal responses to novelty and decreased social investigation in a novel environment.
 
Alleles Annotated to Human Diseases(4)   
Interactions
Nat8l interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process metabolic process, positive regulation of dopamine uptake involved in synaptic transmission
Component cytoplasm, endoplasmic reticulum, ...
Function aspartate N-acetyltransferase activity, N-acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (9)    Images (18)
Theiler Stages: 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 11
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000048142 (Evidence)
Entrez Gene269642 (Evidence)
UniGene274610
DFCITC1577499, TC1600855, TC1651491
DoTSDT.488120, DT.60105126
NIA Mouse Gene IndexU042630
EC2.3.1.17
Consensus CDS ProjectCCDS19210.1
International Mouse Knockout Project StatusNat8l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 269642 NCBI Gene Model | MGI Sequence Detail 9933 C57BL/6J ±  kb
transcript NM_001001985 RefSeq | MGI Sequence Detail 6529 C57BL/6 
polypeptide Q3UGX3 UniProt | EBI | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR000182 GNAT domain
Protein Ontology PR:000011004 N-acetylaspartate synthetase
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207207 Pessentheiner AR, et al., NAT8L (N-acetyltransferase 8-like) accelerates lipid turnover and increases energy expenditure in brown adipocytes. J Biol Chem. 2013 Dec 13;288(50):36040-51
All references(41)
Other
accession IDs
MGI:1916012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory