Dleu7 Gene Detail

Summary

• Symbol
  Dleu7
• Name
  deleted in lymphocytic leukemia, 7
• Synonyms
  MGC:47306

• Feature Type
  protein coding gene
• IDs
  MGI:2447771
  NCBI Gene: 239133
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr14:62276229-62292979 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 33.19 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  63 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447771	protein coding gene	Chr14:62276229-62293047 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021444	protein coding gene	Chr14:56704723-56724774 (-)
A/J	MGP_AJ_G0021403	protein coding gene	Chr14:55445989-55464316 (-)
AKR/J	MGP_AKRJ_G0021379	protein coding gene	Chr14:57428414-57447129 (-)
BALB/cJ	MGP_BALBcJ_G0021409	protein coding gene	Chr14:55399214-55416515 (-)
C3H/HeJ	MGP_C3HHeJ_G0021186	protein coding gene	Chr14:57047274-57068572 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021848	protein coding gene	Chr14:59433406-59452345 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019388	protein coding gene	Chr14:53415622-53432355 (-)
CAST/EiJ	MGP_CASTEiJ_G0020703	protein coding gene	Chr14:53469623-53488588 (-)
CBA/J	MGP_CBAJ_G0021153	protein coding gene	Chr14:61165914-61188211 (-)
DBA/2J	MGP_DBA2J_G0021276	protein coding gene	Chr14:55119194-55136357 (-)
FVB/NJ	MGP_FVBNJ_G0021255	protein coding gene	Chr14:54523749-54544592 (-)
LP/J	MGP_LPJ_G0021351	protein coding gene	Chr14:57750796-57768703 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021284	protein coding gene	Chr14:60473942-60502826 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021871	protein coding gene	Chr14:56567733-56590020 (-)
PWK/PhJ	MGP_PWKPhJ_G0020447	protein coding gene	Chr14:51785779-51806037 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020280	protein coding gene	Chr14:52537177-52560522 (-)
WSB/EiJ	MGP_WSBEiJ_G0020756	protein coding gene	Chr14:56885537-56906676 (-)

Homology

• Human Ortholog
  DLEU7, deleted in lymphocytic leukemia 7

• Vertebrate Orthologs
  7

• Human Ortholog
  DLEU7, deleted in lymphocytic leukemia 7
  Orthology source: HGNC, HomoloGene
• Links
  HGNC:17567

  NCBI Gene ID: 220107

  neXtProt AC: NX_Q6UYE1

  UniProt: Q6UYE1

  
  
• Chr Location
  13q14.3; chr13:50711026-50843939 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 18293
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 macaque, rhesus
  
• HCOP
  human homology predictions: DLEU7
• Gene Tree
  Dleu7
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  9 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  1
• Gene trapped
  13
• Targeted
  3
• Genomic Mutations
  2 involving Dleu7
• Find Mice (IMSR)
  4 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• Assay Results
  17
• Tissues
  2
• cDNA Data
  6
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase dleu7

Interactions

• Dleu7 interacts with 139 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS27188.1
• UniGene
  127330

• Ensembl
  ENSMUSG00000048281 (Evidence)
• NCBI Gene
  239133

Representative Sequences			Length	Strain/Species
genomic	239133	NCBI Gene Model | MGI Sequence Detail	16751	C57BL/6J
transcript	NM_173419	RefSeq | MGI Sequence Detail	1348	C57BL/6
polypeptide	Q8CHZ8	UniProt | EBI | MGI Sequence Detail	209	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000006510 leukemia-associated protein 7
  (term hierarchy)
• InterPro Domains
  IPR031510 Leukemia-associated protein 7

Molecular
Reagents

• All nucleic 6

  cDNA 6

  
  

  Microarray probesets 2

References

• Summaries
  All 28

  Developmental Gene Expression 2

  Diseases 1

  Phenotypes 9
• Earliest
  J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
• Latest
  J:179879 Lia M, et al., Functional dissection of the chromosome 13q14 tumor-suppressor locus using transgenic mouse lines. Blood. 2012 Mar 29;119(13):2981-90

TSS for Dleu7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129103	Chr14:62293228-62293240 (-)	-255 bp
Tssr129102	Chr14:62293177-62293213 (-)	-216 bp
Tssr129101	Chr14:62292959-62293019 (-)	-10 bp