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Dnd1 Gene Detail
Summary
  • Symbol
    Dnd1
  • Name
    DND microRNA-mediated repression inhibitor 1
  • Synonyms
    MGC:41452, RBMS4, Ter
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447763
    NCBI Gene: 213236
Location & Maps
more
  • Sequence Map
    Chr18:36763671-36766214 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2544 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    DND1, DND microRNA-mediated repression inhibitor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DND1, DND microRNA-mediated repression inhibitor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RBMS4
  • Links
    NCBI Gene ID: 373863
    neXtProt AC: NX_Q8IYX4

  • Chr Location
    5q31.3; chr5:140670796-140673586 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    2
  • Incidental Mutations
A semidominant mutation in the 129/Sv strain markedly increases the frequency of testicular teratomas. Homozygous males are germ cell deficient and sterile, while homozygous females have small ovaries, but usually breed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034043 VEGA Gene Model | MGI Sequence Detail 2544 C57BL/6J ±  kb
transcript OTTMUST00000085968 VEGA | MGI Sequence Detail 1451 Not Applicable  
polypeptide OTTMUSP00000046487 VEGA | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006598 dead end protein homolog 1
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-15041, MGI:98710
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 24
  • Earliest
    J:26336 Stevens LC, et al., Spontaneous Testicular Teratomas in an Inbred Strain of Mice. Proc Natl Acad Sci U S A. 1954 Nov;40(11):1080-7
  • Latest
    J:230058 Suzuki A, et al., Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016 Jan;17(1):37-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory