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Tgfbrap1 Gene Detail
Summary
  • Symbol
    Tgfbrap1
  • Name
    transforming growth factor, beta receptor associated protein 1
  • Synonyms
    3110018K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447427
    NCBI Gene: 73122
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:43047200-43098637 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 22.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447427
protein coding gene Chr1:43047200-43098712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015977
protein coding gene Chr1:42009292-42065717 (-)
A/J MGP_AJ_G0015961
protein coding gene Chr1:40754793-40805434 (-)
AKR/J MGP_AKRJ_G0015916
protein coding gene Chr1:41285566-41339392 (-)
BALB/cJ MGP_BALBcJ_G0015915
protein coding gene Chr1:40427910-40480425 (-)
C3H/HeJ MGP_C3HHeJ_G0015748
protein coding gene Chr1:41666229-41720224 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016368
protein coding gene Chr1:43744396-43799360 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014090
protein coding gene Chr1:37587185-37638012 (-)
CAST/EiJ MGP_CASTEiJ_G0015329
protein coding gene Chr1:41652348-41706996 (-)
CBA/J MGP_CBAJ_G0015720
protein coding gene Chr1:45023298-45079878 (-)
DBA/2J MGP_DBA2J_G0015821
protein coding gene Chr1:40029819-40081575 (-)
FVB/NJ MGP_FVBNJ_G0015823
protein coding gene Chr1:39559021-39609373 (-)
LP/J MGP_LPJ_G0015891
protein coding gene Chr1:42359589-42411405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015843
protein coding gene Chr1:47017887-47073023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016415
protein coding gene Chr1:41497582-41552426 (-)
PWK/PhJ MGP_PWKPhJ_G0015112
protein coding gene Chr1:39912830-39965721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014894
protein coding gene Chr1:41489777-41546491 (-)
WSB/EiJ MGP_WSBEiJ_G0015391
protein coding gene Chr1:41536818-41589056 (-)



Homology
more
  • Human Ortholog
    TGFBRAP1, transforming growth factor beta receptor associated protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TGFBRAP1, transforming growth factor beta receptor associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TRAP1, TRAP-1, VPS3
  • Links
    NCBI Gene ID: 9392
    neXtProt AC: NX_Q8WUH2
    UniProt: Q8WUH2

  • Chr Location
    2q12.1-q12.2; chr2:105249404-105329714 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070939 Ensembl Gene Model | MGI Sequence Detail 51438 C57BL/6J ±  kb
transcript ENSMUST00000095014 Ensembl | MGI Sequence Detail 5607 Not Applicable  
polypeptide ENSMUSP00000092624 Ensembl | MGI Sequence Detail 860 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003163 transforming growth factor-beta receptor-associated protein 1
  • InterPro Domains
    IPR001180 Citron homology (CNH) domain
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR019452 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
    IPR019453 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
    IPR032914 Vam6/VPS39/TRAP1 family
Molecular
Reagents
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  • All nucleic 67
    cDNA 67

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920372, MGI:2138478, MGI:2138496, MGI:2138624
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:222663 Perini ED, et al., Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Traffic. 2014 Dec;15(12):1366-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory