About   Help   FAQ
Smg5 Gene Detail
Summary
  • Symbol
    Smg5
  • Name
    Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Synonyms
    MGC:30464, MGC:56792, mKIAA1089
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447364
    NCBI Gene: 229512
  • Gene Overview
    MyGene.info: SMG5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88336260-88362337 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447364
protein coding gene Chr3:88336260-88362338 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027391
protein coding gene Chr3:88488879-88517403 (+)
A/J MGP_AJ_G0027355
protein coding gene Chr3:85493071-85519129 (+)
AKR/J MGP_AKRJ_G0027321
protein coding gene Chr3:87595765-87623733 (+)
BALB/cJ MGP_BALBcJ_G0027364
protein coding gene Chr3:85582532-85609397 (+)
C3H/HeJ MGP_C3HHeJ_G0027107
protein coding gene Chr3:87873994-87899871 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027810
protein coding gene Chr3:91746548-91776444 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025163
protein coding gene Chr3:81111250-81138942 (+)
CAST/EiJ MGP_CASTEiJ_G0026553
protein coding gene Chr3:88084936-88115668 (+)
CBA/J MGP_CBAJ_G0027082
protein coding gene Chr3:94872177-94898164 (+)
DBA/2J MGP_DBA2J_G0027218
protein coding gene Chr3:84981772-85008437 (+)
FVB/NJ MGP_FVBNJ_G0027187
protein coding gene Chr3:83251321-83279092 (+)
LP/J MGP_LPJ_G0027326
protein coding gene Chr3:89482734-89511917 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027206
protein coding gene Chr3:101101786-101134417 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027868
protein coding gene Chr3:87350700-87379733 (+)
PWK/PhJ MGP_PWKPhJ_G0026286
protein coding gene Chr3:84779440-84807355 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026104
protein coding gene Chr3:86540883-86570148 (+)
WSB/EiJ MGP_WSBEiJ_G0026633
protein coding gene Chr3:87705602-87732372 (+)



Homology
more
  • Human Ortholog
    SMG5, SMG5, nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SMG5, SMG5, nonsense mediated mRNA decay factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EST1B, LPTSRP1, LPTS-RP1, SMG-5
  • Links
    NCBI Gene ID: 23381
    neXtProt AC: NX_Q9UPR3
    UniProt: Q9UPR3

  • Chr Location
    1q22; chr1:156249224-156291498 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9095
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMG5
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 229512 NCBI Gene Model | MGI Sequence Detail 26078 C57BL/6J ±  kb
transcript NM_178246 RefSeq | MGI Sequence Detail 4447 C57BL/6  
polypeptide Q6ZPY2 UniProt | EBI | MGI Sequence Detail 1017 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 143
    cDNA 143

    Microarray probesets 5
References
more
  • Summaries
    All 36
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:222980 Li T, et al., Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J. 2015 Jun 12;34(12):1630-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory