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Smg5 Gene Detail
Summary
  • Symbol
    Smg5
  • Name
    Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Synonyms
    MGC:30464, MGC:56792, mKIAA1089
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447364
    NCBI Gene: 229512
  • Gene Overview
    MyGene.info: SMG5
Location & Maps
more
  • Sequence Map
    Chr3:88336260-88362338 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26079 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.80 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SMG5, SMG5, nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SMG5, SMG5, nonsense mediated mRNA decay factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EST1B, LPTSRP1, LPTS-RP1, SMG-5
  • Links
    NCBI Gene ID: 23381
    neXtProt AC: NX_Q9UPR3

  • Chr Location
    1q21.2; chr1:156249224-156282885 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9095
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: SMG5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    50
  • Chemically induced (other)
    1
  • Gene trapped
    46
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Smg5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052142 VEGA Gene Model | MGI Sequence Detail 26079 C57BL/6J ±  kb
transcript OTTMUST00000131031 VEGA | MGI Sequence Detail 4448 Not Applicable  
polypeptide OTTMUSP00000070126 VEGA | MGI Sequence Detail 1017 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 142
    cDNA 142

    Microarray probesets 5
References
more
  • Summaries
    All 31
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:222980 Li T, et al., Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J. 2015 Jun 12;34(12):1630-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory