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Slc24a4 Gene Detail
Summary
  • Symbol
    Slc24a4
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
  • Synonyms
    A930002M03Rik, NCKX4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447362
    NCBI Gene: 238384
Location & Maps
more
  • Sequence Map
    Chr12:102128733-102267091 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      138359 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.42 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC24A4, solute carrier family 24 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC24A4, solute carrier family 24 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI2A5, NCKX4, SHEP6, SLC24A2
  • Links
    NCBI Gene ID: 123041
    neXtProt AC: NX_Q8NFF2

  • Chr Location
    14q32.12; chr14:92322581-92501481 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC24A4 associations

Human Disease Mouse Models
       Amelogenesis Imperfecta, Hypomaturation Type, Iia5; AI2A5   OMIM: 615887
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Slc24a4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired olfactory response and reduced weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033883 VEGA Gene Model | MGI Sequence Detail 138359 C57BL/6J ±  kb
transcript OTTMUST00000085434 VEGA | MGI Sequence Detail 2337 Not Applicable  
polypeptide OTTMUSP00000046151 VEGA | MGI Sequence Detail 605 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1040 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR004837 Sodium/calcium exchanger membrane region
    IPR004481 Sodium/potassium/calcium exchanger
    IPR030232 Sodium/potassium/calcium exchanger 4
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2145028, MGI:2443586
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory