Phospho1 MGI Mouse Gene Detail - MGI:2447348

Phospho1 Gene Detail

Symbol

Phospho1
Name

phosphatase, orphan 1
Synonyms

D11Moh36

Feature Type

protein coding gene
IDs

MGI:2447348
NCBI Gene: 237928
Gene Overview

MyGene.info: PHOSPHO1

Sequence Map

Chr11:95824499-95832140 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

7642 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

3 experiments

Human Ortholog

PHOSPHO1, phosphoethanolamine/phosphocholine phosphatase

Vertebrate Orthologs

9

Human Ortholog

PHOSPHO1, phosphoethanolamine/phosphocholine phosphatase
Orthology source: HomoloGene, HGNC
Links

HGNC:16815

NCBI Gene ID: 162466

neXtProt AC: NX_Q8TCT1

UniProt: Q8TCT1
Chr Location

17q21.32; chr17:49223369-49230766 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 13330
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PHOSPHO1
Protein SuperFamily

pyridoxal phosphate phosphatase, PHOSPHO2 type
Gene Tree

Phospho1

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Phenotype Summary

30 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (ENU)

1
Targeted

4
Genomic Mutations

2 involving Phospho1
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available

Mice homozygous for an ENU-induced mutation exhibit fractures, bowed long bones, osteomalacia, and scoliosis.

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All GO Annotations

13
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

237
Tissues

114
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PHOSPHO1

ZFIN phospho1

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Phospho1 interacts with 74 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

24
RefSeq

2
UniProt

3
CCDS

CCDS36288.1
UniGene

133075

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001750	VEGA Gene Model \| MGI Sequence Detail	7642	C57BL/6J	± kb
transcript	OTTMUST00000003488	VEGA \| MGI Sequence Detail	1910	Not Applicable
polypeptide	OTTMUSP00000001683	VEGA \| MGI Sequence Detail	267	Not Applicable

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SNPs within 2kb

72 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000012669 phosphoethanolamine/phosphocholine phosphatase

(term hierarchy)
EC

3.1.3.75
InterPro Domains

IPR023214 HAD-like domain

IPR016965 Phosphatase PHOSPHO-type

IPR006384 Pyridoxal phosphate phosphatase-related

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All nucleic 16

Genomic 7

cDNA 9

Microarray probesets 2

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MGI:1343159

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 12
Earliest

J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
Latest

J:228443 Javaheri B, et al., Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. Bone. 2015 Dec;81:277-91

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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