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Cmtm2a Gene Detail
Summary
  • Symbol
    Cmtm2a
  • Name
    CKLF-like MARVEL transmembrane domain containing 2A
  • Synonyms
    1700001K04Rik, 1700041N15Rik, 1700063K20Rik, ARR19, Cklf, Cklfsf2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447160
    NCBI Gene: 73381
  • Gene Overview
    MyGene.info: CMTM2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:104281042-104293181 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447160
protein coding gene Chr8:104281042-104293181 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034004
protein coding gene Chr8:106398558-106415518 (-)
A/J MGP_AJ_G0033985
protein coding gene Chr8:102173705-102190541 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0033978
protein coding gene Chr8:102403640-102416519 (-)
C3H/HeJ MGP_C3HHeJ_G0033690
protein coding gene Chr8:105828891-105851888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034499
protein coding gene Chr8:110299737-110314638 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031442
protein coding gene Chr8:95477476-95489684 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0033664
protein coding gene Chr8:113944217-113965763 (-)
DBA/2J MGP_DBA2J_G0033818
protein coding gene Chr8:101542466-101557982 (-)
FVB/NJ MGP_FVBNJ_G0033765
protein coding gene Chr8:100477329-100490966 (-)
LP/J MGP_LPJ_G0033909
protein coding gene Chr8:106588625-106606355 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033807
protein coding gene Chr8:117128574-117157682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034516
protein coding gene Chr8:105094299-105112816 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0032559
protein coding gene Chr8:103928603-103936545 (-)
WSB/EiJ MGP_WSBEiJ_G0033133
protein coding gene Chr8:105771844-105785379 (-)



Homology
more
  • Human Ortholog
    CMTM2, CKLF like MARVEL transmembrane domain containing 2
  • Vertebrate Orthologs
    2
  • Human Ortholog
    CMTM2, CKLF like MARVEL transmembrane domain containing 2
    Orthology source: HGNC
  • Synonyms
    CKLFSF2
  • Links
    NCBI Gene ID: 146225
    neXtProt AC: NX_Q8TAZ6
    UniProt: Q8TAZ6

  • Chr Location
    16q21; chr16:66579448-66588275 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for a knock-out alleles of Cmtm2a and Cmtm2b exhibit impaired male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73381 NCBI Gene Model | MGI Sequence Detail 12140 C57BL/6J ±  kb
transcript NM_027022 RefSeq | MGI Sequence Detail 1084 C57BL/6  
polypeptide Q9DAR1 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 1
Other
Accession IDs
less
MGI:1916540, MGI:1920513, MGI:1920631, MGI:2142551
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:266476 Fujihara Y, et al., Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice. J Cell Sci. 2018 Oct 8;131(19)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory