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Tenm4
Gene Detail
Symbol

Name
ID
Tenm4
teneurin transmembrane protein 4
MGI:2447063
Synonyms
Doc4, ELM2, l(7)-3Rn, l7Rn3, mKIAA1302, Odz4, Ten-m4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
52.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:96171244-96911093 bp, + strand
From VEGA annotation of GRCm38

  739850 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8034  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tenm4

Human
homologs
Human Homolog TENM4, teneurin transmembrane protein 4
NCBI Gene ID 26011
neXtProt AC  NX_Q6N022
Human Synonyms  Doc4, ODZ4, Ten-M4, TNM4
Human Chr (Location)  11q14.1; chr11:78653283-79440651 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(207) : Chemically induced (ENU)(6) Gene trapped(196) Targeted(4) Transgenic(1)
Incidental mutations (data from APF )
 
Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance.
 
Interactions
Tenm4 interacts with 434 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cardiac cell fate specification, cardiac muscle cell proliferation, ...
Component cell projection, cytoplasm, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (94)    Tissues (58)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 74
RT-PCR 14
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000021244 (Evidence)
Ensembl Gene ModelENSMUSG00000048078 (Evidence)
Entrez Gene23966 (Evidence)
DFCITC1579154, TC1719541, TC1607398, TC1629460, TC1621804, TC1614598, TC1620143
Consensus CDS ProjectCCDS40024.1
International Mouse Knockout Project StatusTenm4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021244 VEGA Gene Model | MGI Sequence Detail 739850 C57BL/6J ±  kb
transcript OTTMUST00000050348 VEGA | MGI Sequence Detail 13469 Not Applicable 
polypeptide OTTMUSP00000023492 VEGA | MGI Sequence Detail 2833 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(46) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(7275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008969 Carboxypeptidase-like, regulatory domain
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR022385 Rhs repeat-associated core
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR009471 Teneurin intracellular, N-terminal
InterPro IPR006530 YD repeat
Protein Ontology PR:000011609 teneurin-4
References
(Earliest) J:10283 Rinchik EM, et al., A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis. Proc Natl Acad Sci U S A. 1990 Feb;87(3):896-900
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(54)
Other
accession IDs
MGD-MRK-11691, MGD-MRK-11723, MGI:2142385, MGI:96735

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory