Kif19a MGI Mouse Gene Detail - MGI:2447024

Symbol

Kif19a
Name

kinesin family member 19A
Synonyms

N-8 kinesin

Feature Type

protein coding gene
IDs

MGI:2447024
NCBI Gene: 286942
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:114765388-114790739 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.44 cM
Mapping Data

1 experiment

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447024	protein coding gene	Chr11:114764970-114791166 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019359	protein coding gene	Chr11:118704232-118730688 (+)
A/J	MGP_AJ_G0019328	protein coding gene	Chr11:113543370-113568817 (+)
AKR/J	MGP_AKRJ_G0019296	protein coding gene	Chr11:116902769-116928191 (+)
BALB/cJ	MGP_BALBcJ_G0019301	protein coding gene	Chr11:113961804-113988101 (+)
C3H/HeJ	MGP_C3HHeJ_G0019110	protein coding gene	Chr11:117250715-117277408 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019752	protein coding gene	Chr11:122268848-122295632 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017375	protein coding gene	Chr11:110609469-110635377 (+)
CAST/EiJ	MGP_CASTEiJ_G0018664	protein coding gene	Chr11:118582808-118608945 (+)
CBA/J	MGP_CBAJ_G0019080	protein coding gene	Chr11:127152421-127183543 (+)
DBA/2J	MGP_DBA2J_G0019192	protein coding gene	Chr11:112985053-113011160 (+)
FVB/NJ	MGP_FVBNJ_G0019183	protein coding gene	Chr11:112463427-112494192 (+)
LP/J	MGP_LPJ_G0019262	protein coding gene	Chr11:119110716-119136102 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019214	protein coding gene	Chr11:126316968-126343433 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019789	protein coding gene	Chr11:117574174-117604307 (+)
PWK/PhJ	MGP_PWKPhJ_G0018429	protein coding gene	Chr11:114219907-114247054 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018221	protein coding gene	Chr11:117380234-117407218 (+)
WSB/EiJ	MGP_WSBEiJ_G0018716	protein coding gene	Chr11:117536185-117561679 (+)

Human Ortholog

KIF19, kinesin family member 19

Vertebrate Orthologs

9

Human Ortholog

KIF19, kinesin family member 19
Orthology source: HomoloGene, HGNC
Synonyms

KIF19A
Links

HGNC:26735

NCBI Gene ID: 124602

neXtProt AC: NX_Q2TAC6

UniProt: Q2TAC6
Chr Location

17q25.1; chr17:74326212-74355820 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 17709
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KIF19
Gene Tree

Kif19a

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display partial postnatal lethality, hydroencephaly, female infertility, oviduct obstruction, increased motile cilium length and impaired motile cilium movement.

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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Kif19a interacts with 52 markers (Mir10b, Mir17, Mir18, ...) View All

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All Sequences

41
RefSeq

2
UniProt

4
CCDS

CCDS36367.1
UniGene

308713

Ensembl

ENSMUSG00000010021 (Evidence)
NCBI Gene

286942

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010021	Ensembl Gene Model \| MGI Sequence Detail	25352	C57BL/6J	± kb
transcript	ENSMUST00000084368	Ensembl \| MGI Sequence Detail	3433	Not Applicable
polypeptide	ENSMUSP00000081398	Ensembl \| MGI Sequence Detail	997	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009294 kinesin-like protein KIF19

(term hierarchy)
PDB

5GSY, 5GSZ
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 5

cDNA 5

Microarray probesets 1

Summaries

All 19

Gene Ontology 4

Phenotypes 3
Earliest

J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
Latest

J:238499 Wang D, et al., Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A. Elife. 2016 Sep 30;5

TSS for Kif19a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105787	Chr11:114765363-114765438 (+)	13 bp
Tssr105788	Chr11:114765444-114765456 (+)	62 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/19/2021 MGI 6.16