About   Help   FAQ
Kif19a Gene Detail
Summary
  • Symbol
    Kif19a
  • Name
    kinesin family member 19A
  • Synonyms
    N-8 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447024
    NCBI Gene: 286942
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:114765388-114790739 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447024
 protein coding gene Chr11:114764970-114791166 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019359
 protein coding gene Chr11:118704232-118730688 (+)
A/J MGP_AJ_G0019328
 protein coding gene Chr11:113543370-113568817 (+)
AKR/J MGP_AKRJ_G0019296
 protein coding gene Chr11:116902769-116928191 (+)
BALB/cJ MGP_BALBcJ_G0019301
 protein coding gene Chr11:113961804-113988101 (+)
C3H/HeJ MGP_C3HHeJ_G0019110
 protein coding gene Chr11:117250715-117277408 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019752
 protein coding gene Chr11:122268848-122295632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017375
 protein coding gene Chr11:110609469-110635377 (+)
CAST/EiJ MGP_CASTEiJ_G0018664
 protein coding gene Chr11:118582808-118608945 (+)
CBA/J MGP_CBAJ_G0019080
 protein coding gene Chr11:127152421-127183543 (+)
DBA/2J MGP_DBA2J_G0019192
 protein coding gene Chr11:112985053-113011160 (+)
FVB/NJ MGP_FVBNJ_G0019183
 protein coding gene Chr11:112463427-112494192 (+)
LP/J MGP_LPJ_G0019262
 protein coding gene Chr11:119110716-119136102 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019214
 protein coding gene Chr11:126316968-126343433 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019789
 protein coding gene Chr11:117574174-117604307 (+)
PWK/PhJ MGP_PWKPhJ_G0018429
 protein coding gene Chr11:114219907-114247054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018221
 protein coding gene Chr11:117380234-117407218 (+)
WSB/EiJ MGP_WSBEiJ_G0018716
 protein coding gene Chr11:117536185-117561679 (+)



Homology
more
  • Human Ortholog
    KIF19, kinesin family member 19
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF19, kinesin family member 19
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIF19A
  • Links
    NCBI Gene ID: 124602
    neXtProt AC: NX_Q2TAC6
    UniProt: Q2TAC6

  • Chr Location
    17q25.1; chr17:74326212-74355820 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display partial postnatal lethality, hydroencephaly, female infertility, oviduct obstruction, increased motile cilium length and impaired motile cilium movement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010021 Ensembl Gene Model | MGI Sequence Detail 25352 C57BL/6J ±  kb
transcript ENSMUST00000084368 Ensembl | MGI Sequence Detail 3433 Not Applicable  
polypeptide ENSMUSP00000081398 Ensembl | MGI Sequence Detail 997 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
  • Latest
    J:238499 Wang D, et al., Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A. Elife. 2016 Sep 30;5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
11/26/2019
MGI 6.14 		The Jackson Laboratory