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Ago2 Gene Detail
Summary
  • Symbol
    Ago2
  • Name
    argonaute RISC catalytic subunit 2
  • Synonyms
    1110029L17Rik, 2310051F07Rik, argonaute 2, Eif2c2, mKIAA1567
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446632
    NCBI Gene: 239528
  • Gene Overview
    MyGene.info: AGO2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:73095844-73184840 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88997 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 33.92 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AGO2, argonaute 2, RISC catalytic component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGO2, argonaute 2, RISC catalytic component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CASC7, EIF2C2, LINC00980, PPD, Q10
  • Links
    NCBI Gene ID: 27161
    neXtProt AC: NX_Q9UKV8
    UniProt: Q9UKV8

  • Chr Location
    8q24.3; chr8:140520158-140642406 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    14 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with neural tube defects, abnormal forebrain patterning, enlarged hearts, pericardial swelling, delayed development, and defects in the yolk sac and placenta.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000040103 VEGA Gene Model | MGI Sequence Detail 88997 C57BL/6J ±  kb
    transcript OTTMUST00000104179 VEGA | MGI Sequence Detail 13705 Not Applicable  
    polypeptide OTTMUSP00000058272 VEGA | MGI Sequence Detail 860 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      408 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 23
      Primer pair 4
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
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    MGI:1915972, MGI:1917438, MGI:2145960, MGI:2146112, MGI:2146228
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 25
      Phenotypes 48
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260599 Belanger C, et al., Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E620-E629

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory