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Ago1 Gene Detail
Summary
  • Symbol
    Ago1
  • Name
    argonaute RISC catalytic subunit 1
  • Synonyms
    argonaute 1, Eif2c1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446630
    NCBI Gene: 236511
  • Gene Overview
    MyGene.info: AGO1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126435012-126468583 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 60.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446630
protein coding gene Chr4:126435012-126468709 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028781
protein coding gene Chr4:128116777-128150339 (-)
A/J MGP_AJ_G0028740
protein coding gene Chr4:123078426-123111926 (-)
AKR/J MGP_AKRJ_G0028693
protein coding gene Chr4:126458708-126492254 (-)
BALB/cJ MGP_BALBcJ_G0028763
protein coding gene Chr4:123649874-123683528 (-)
C3H/HeJ MGP_C3HHeJ_G0028477
protein coding gene Chr4:126521165-126554695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029205
protein coding gene Chr4:133004940-133038674 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026478
protein coding gene Chr4:116211575-116244870 (-)
CAST/EiJ MGP_CASTEiJ_G0027910
protein coding gene Chr4:124626417-124667683 (-)
CBA/J MGP_CBAJ_G0028443
protein coding gene Chr4:136205969-136239533 (-)
DBA/2J MGP_DBA2J_G0028592
protein coding gene Chr4:123526328-123560698 (-)
FVB/NJ MGP_FVBNJ_G0028559
protein coding gene Chr4:122179174-122212947 (-)
LP/J MGP_LPJ_G0028693
protein coding gene Chr4:128402836-128436290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028585
protein coding gene Chr4:141245903-141279399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029243
protein coding gene Chr4:126812630-126848981 (-)
PWK/PhJ MGP_PWKPhJ_G0027631
protein coding gene Chr4:120012092-120051146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027457
protein coding gene Chr4:122633997-122670647 (-)
WSB/EiJ MGP_WSBEiJ_G0027990
protein coding gene Chr4:126924480-126958085 (-)



Homology
more
  • Human Ortholog
    AGO1, argonaute 1, RISC catalytic component
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AGO1, argonaute 1, RISC catalytic component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF2C, EIF2C1, GERP95, hAgo1, Q99
  • Links
    NCBI Gene ID: 26523
    neXtProt AC: NX_Q9UL18
    UniProt: Q9UL18

  • Chr Location
    1p34.3; chr1:35869808-35929610 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in keratinocytes exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041530 Ensembl Gene Model | MGI Sequence Detail 33572 C57BL/6J ±  kb
    transcript ENSMUST00000097888 Ensembl | MGI Sequence Detail 7227 Not Applicable  
    polypeptide ENSMUSP00000095498 Ensembl | MGI Sequence Detail 857 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:258947 Pua HH, et al., MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production. Immunity. 2016 Apr 19;44(4):821-32

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory