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Ago1
Gene Detail
 Symbol
Name
ID
Ago1
argonaute RISC catalytic subunit 1
MGI:2446630
Synonyms argonaute 1, Eif2c1
Feature Type protein coding gene
Genetic Map
Chromosome 4
60.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:126435012-126468583 bp, - strand
From VEGA annotation of GRCm38

  33572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: argonaute family protein
Gene Tree: Ago1

Human
homologs
Human Homolog AGO1, argonaute RISC catalytic component 1
NCBI Gene ID 26523
neXtProt AC  NX_Q9UL18
Human Synonyms  EIF2C, EIF2C1, GERP95, Q99
Human Chr (Location)  1p34.3; chr1:35883209-35929610 (+)  GRCh38
Alleles
and
phenotypes
All alleles(134) : Targeted(3) Gene trapped(131)
 
Mice homozygous for a conditional allele activated in keratinocytes exhibit no abnormal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process gene silencing by RNA, negative regulation of translation involved in gene silencing by miRNA, ...
Component cytoplasm, cytoplasmic mRNA processing body, ...
Function nucleic acid binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (157)    Tissues (27)    Images (23)
Theiler Stages: 2, 3, 19, 22, 23
Assay TypeResults
RNA in situ 121
RT-PCR 36
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009219 (Evidence)
Ensembl Gene ModelENSMUSG00000041530 (Evidence)
Entrez Gene236511 (Evidence)
DFCITC1582151, TC1601842, TC1603638, TC1714459
Consensus CDS ProjectCCDS18653.1
International Mouse Knockout Project StatusAgo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009219 VEGA Gene Model | MGI Sequence Detail 33572 C57BL/6J ±  kb
transcript OTTMUST00000020859 VEGA | MGI Sequence Detail 7227 Not Applicable 
polypeptide OTTMUSP00000009563 VEGA | MGI Sequence Detail 857 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR014811 Domain of unknown function DUF1785
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR003165 Stem cell self-renewal protein Piwi
Protein Ontology PR:000006967 protein argonaute-1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:200238 Polikepahad S, et al., Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2. Nucleic Acids Res. 2013 Jan;41(2):1164-77
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory