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Ago1
Gene Detail
Symbol

Name
ID
Ago1
argonaute RISC catalytic subunit 1
MGI:2446630
Synonyms
argonaute 1, Eif2c1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
60.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:126435012-126468583 bp, - strand
From VEGA annotation of GRCm38

  33572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81826  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGO1
Protein SuperFamily: argonaute family protein
Gene Tree: Ago1

Human
homologs
AGO1, argonaute RISC catalytic component 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26523
neXtProt AC: NX_Q9UL18

Human Synonyms: EIF2C, EIF2C1, GERP95, Q99

Human Chr (Location): 1p34.3; chr1:35869791-35924298 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(136) : Gene trapped(131) Targeted(5)
Genomic Mutations involving Ago1 (2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a conditional allele activated in keratinocytes exhibit no abnormal phenotype.
 
Interactions
Ago1 interacts with 470 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (157)    Tissues (27)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
RT-PCR 36
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA AGO1 ; Xenbase ago4 ; ZFIN ago1    NEW 
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009219 (Evidence)
Ensembl Gene Model ENSMUSG00000041530 (Evidence)
Entrez Gene 236511 (Evidence)
DFCI TC1582151, TC1601842, TC1603638, TC1714459
Consensus CDS Project CCDS18653.1
International Mouse Phenotyping Consortium Status Ago1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009219 VEGA Gene Model | MGI Sequence Detail 33572 C57BL/6J ±  kb
transcript OTTMUST00000020859 VEGA | MGI Sequence Detail 7227 Not Applicable 
polypeptide OTTMUSP00000009563 VEGA | MGI Sequence Detail 857 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014811 Argonaute, linker 1 domain
InterPro IPR003100 PAZ domain
InterPro IPR003165 Piwi domain
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000006967 protein argonaute-1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:200238 Polikepahad S, et al., Profiling of T helper cell-derived small RNAs reveals unique antisense transcripts and differential association of miRNAs with argonaute proteins 1 and 2. Nucleic Acids Res. 2013 Jan;41(2):1164-77
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory