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Cpt1c
Gene Detail
Symbol

Name
ID
Cpt1c
carnitine palmitoyltransferase 1c
MGI:2446526
Synonyms
9630004I06Rik, CPT I-C
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.07 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44959373-44974851 bp, - strand
From Ensembl annotation of GRCm38

  15479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17561  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Cpt1c

Human
homologs
Human Homolog CPT1C, carnitine palmitoyltransferase 1C
NCBI Gene ID 126129
neXtProt AC  NX_Q8TCG5
Human Synonyms  CATL1, CPT1-B, CPT1P, CPTI-B, CPTIC
Human Chr (Location)  19q13.33; chr19:49691106-49713731 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(26) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutations in this gene result in reduced body weight, increases in circulating fatty acid levels and mild insulin resistance. Mice homozygous for a different targeted knock-out exhibit reduced ceramide levels, impaired dendritic spine maturation and impaired spatial learning.
 
Interactions
Cpt1c interacts with 34 markers (Mir23a, Mir23b, Mir30c-1, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (294)    Tissues (162)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 294
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(33) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000007783 (Evidence)
Entrez Gene78070 (Evidence)
UniGene231465
DFCITC1579741, TC1592214, TC1618217
DoTSDT.101724922, DT.101366701, DT.97351320, DT.111001484, DT.111001483
NIA Mouse Gene IndexU123195
EC2.3.1.21
Consensus CDS ProjectCCDS21221.1
International Mouse Knockout Project StatusCpt1c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007783 Ensembl Gene Model | MGI Sequence Detail 15479 C57BL/6J ±  kb
transcript ENSMUST00000063761 Ensembl | MGI Sequence Detail 2793 Not Applicable 
polypeptide ENSMUSP00000069539 Ensembl | MGI Sequence Detail 798 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(26) UniProt(5)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)    SNPs within 2kb including multiple locations(213)
Protein-related
information
ResourceIDDescription
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
Protein Ontology PR:000005837 carnitine O-palmitoyltransferase 1, brain isoform
References
(Earliest) J:79496 Price N, et al., A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics. 2002 Oct;80(4):433-42
(Latest) J:208667 Ramirez S, et al., Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin. Diabetes. 2013 Jul;62(7):2329-37
All references(45)
Other
accession IDs
MGI:2442291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory