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Megf8 Gene Detail
Summary
  • Symbol
    Megf8
  • Name
    multiple EGF-like-domains 8
  • Synonyms
    b2b1702Clo, b2b288Clo, Egfl4, m687Ddg, mKIAA0817
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446294
    NCBI Gene: 269878
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25317164-25365917 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446294
protein coding gene Chr7:25316736-25365917 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031863
protein coding gene Chr7:23772957-23831362 (+)
A/J MGP_AJ_G0031842
protein coding gene Chr7:23163023-23213082 (+)
AKR/J MGP_AKRJ_G0031771
protein coding gene Chr7:23706959-23760231 (+)
BALB/cJ MGP_BALBcJ_G0031849
protein coding gene Chr7:23377048-23426762 (+)
C3H/HeJ MGP_C3HHeJ_G0031568
protein coding gene Chr7:24141302-24193138 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032311
protein coding gene Chr7:24568759-24631612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029366
protein coding gene Chr7:24585450-24635731 (+)
CAST/EiJ MGP_CASTEiJ_G0030908
protein coding gene Chr7:17614361-17677134 (+)
CBA/J MGP_CBAJ_G0031533
protein coding gene Chr7:25483429-25542499 (+)
DBA/2J MGP_DBA2J_G0031687
protein coding gene Chr7:23066408-23115183 (+)
FVB/NJ MGP_FVBNJ_G0031640
protein coding gene Chr7:23066119-23118069 (+)
LP/J MGP_LPJ_G0031766
protein coding gene Chr7:24077902-24130508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031677
protein coding gene Chr7:25187258-25245129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032343
protein coding gene Chr7:23414978-23466869 (+)
PWK/PhJ MGP_PWKPhJ_G0030632
protein coding gene Chr7:18004319-18063248 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030463
protein coding gene Chr7:14725722-14785503 (+)
WSB/EiJ MGP_WSBEiJ_G0031011
protein coding gene Chr7:23590723-23649936 (+)



Homology
more
  • Human Ortholog
    MEGF8, multiple EGF like domains 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MEGF8, multiple EGF like domains 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf49, CRPT2, EGFL4, SBP1
  • Links
    NCBI Gene ID: 1954
    neXtProt AC: NX_Q7Z7M0
    UniProt: Q7Z7M0

  • Chr Location
    19q13.2; chr19:42325609-42378769 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Megf8 mouse models; 1 with human MEGF8 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 7 alleles in 10 genetic backgrounds
    17 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045039 Ensembl Gene Model | MGI Sequence Detail 48754 C57BL/6J ±  kb
transcript ENSMUST00000128119 Ensembl | MGI Sequence Detail 10040 Not Applicable  
polypeptide ENSMUSP00000122192 Ensembl | MGI Sequence Detail 2789 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    Genomic 2
    cDNA 80

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142194, MGI:4455306, MGI:5311335, MGI:5437069
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:253667 Pusapati GV, et al., CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018 Jan 8;44(1):113-129.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory