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Megf8
Gene Detail
Symbol

Name
ID
Megf8
multiple EGF-like-domains 8
MGI:2446294
Synonyms
b2b1702Clo, b2b288Clo, Egfl4, m687Ddg, mKIAA0817
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:25317164-25365917 bp, + strand
From VEGA annotation of GRCm38

  48754 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15988  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MEGF8
Gene Tree: Megf8

Human
homologs
MEGF8, multiple EGF-like-domains 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1954
neXtProt AC: NX_Q7Z7M0

Human Synonyms: C19orf49, CRPT2, EGFL4, SBP1

Human Chr (Location): 19q12; chr19:42325609-42378769 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MEGF8

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(4) Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system.
 
Human Diseases Modeled in Mice Using Megf8 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(26)
Interactions
Megf8 interacts with 216 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process BMP signaling pathway, cell migration involved in gastrulation, ...
Component extracellular exosome, integral component of membrane, ...
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase megf8    NEW 
Molecular
reagents
All nucleic(81) Genomic(1) cDNA(80)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033805 (Evidence)
Ensembl Gene Model ENSMUSG00000045039 (Evidence)
Entrez Gene 269878 (Evidence)
UniGene 38527
DFCI TC1597028, TC1601116
DoTS DT.488415, DT.97392813
NIA Mouse Gene Index U079279
Consensus CDS Project CCDS52148.1
International Mouse Phenotyping Consortium Status Megf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033805 VEGA Gene Model | MGI Sequence Detail 48754 C57BL/6J ±  kb
transcript OTTMUST00000085155 VEGA | MGI Sequence Detail 10040 Not Applicable 
polypeptide OTTMUSP00000045973 VEGA | MGI Sequence Detail 2789 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(301 from dbSNP Build 137)    SNPs within 2kb including multiple locations(303)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015915 Kelch-type beta propeller
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
Protein Ontology PR:000032781 multiple epidermal growth factor-like domains protein 8
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4
All references(36)
Disease annotation references (1)
Other
accession IDs
MGI:2142194, MGI:4455306, MGI:5311335, MGI:5437069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory