Megf8
Gene Detail

Symbol Name ID

Megf8 multiple EGF-like-domains 8 MGI:2446294

Synonyms

b2b1702Clo, b2b288Clo, Egfl4, mKIAA0817

Feature Type

protein coding gene

Genetic Map

Chromosome 7

13.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:25317164-25365917 bp, + strand From VEGA annotation of GRCm38   48754 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15988  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Megf8

Human homologs

Human Homolog		MEGF8, multiple EGF-like-domains 8
NCBI Gene ID		1954
neXtProt AC		NX_Q7Z7M0
Human Synonyms		C19orf49, CRPT2, EGFL4, SBP1
Human Chr (Location)		19q12; chr19:42829761-42882921 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MEGF8

Alleles and phenotypes

All alleles(6) : Targeted(1) Gene trapped(2) Chemically induced(3)
 

Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects.

 
Human Diseases Modeled Using Mouse Megf8 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(26)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	determination of digestive tract left/right asymmetry, determination of heart left/right asymmetry, ...
Component	integral to membrane, nucleus
Function	calcium ion binding

External Resources: FuncBase

Expression

cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(81) Genomic(1) cDNA(80)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033805 (Evidence)
Ensembl Gene Model	ENSMUSG00000045039 (Evidence)
Entrez Gene	269878 (Evidence)
UniGene	38527
DFCI	TC1597028, TC1601116
DoTS	DT.488415, DT.97392813
NIA Mouse Gene Index	U079279
Consensus CDS Project	CCDS52148.1
International Mouse Knockout Project Status	Megf8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033805	VEGA Gene Model | MGI Sequence Detail	48754	C57BL/6J
transcript	OTTMUST00000085155	VEGA | MGI Sequence Detail	10040	Not Applicable
polypeptide	OTTMUSP00000045973	VEGA | MGI Sequence Detail	2789	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(145 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000859	CUB
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR015915	Kelch-type beta propeller
InterPro	IPR002165	Plexin
InterPro	IPR003659	Plexin/semaphorin/integrin
Protein Ontology	PR:000032781	multiple epidermal growth factor-like domains protein 8

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Other accession IDs

MGI:2142194, MGI:5311335, MGI:5437069