About   Help   FAQ
Vps33b Gene Detail
Summary
  • Symbol
    Vps33b
  • Name
    vacuolar protein sorting 33B
  • Synonyms
    MGC:36556
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446237
    NCBI Gene: 233405
  • Gene Overview
    MyGene.info: VPS33B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:80269649-80291754 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22106 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.59 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VPS33B, VPS33B, late endosome and lysosome associated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS33B, VPS33B, late endosome and lysosome associated
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 26276
    neXtProt AC: NX_Q9H267
    UniProt: Q9H267

  • Chr Location
    15q26.1; chr15:90998416-91022621 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Vps33b mouse models; 1 with human VPS33B associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated by an inducible cre exhibit dry scaly skin, hair loss, thrombocytosis, abnormal alpha-granule development, extramedullary hematopoiesis, abnormal platelets and megakaryocytes, and defects in tail tendon collagen I structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017577 VEGA Gene Model | MGI Sequence Detail 22106 C57BL/6J ±  kb
    transcript OTTMUST00000042739 VEGA | MGI Sequence Detail 2574 Not Applicable  
    polypeptide OTTMUSP00000019195 VEGA | MGI Sequence Detail 617 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      257 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory