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Vps33b Gene Detail
Summary
  • Symbol
    Vps33b
  • Name
    vacuolar protein sorting 33B
  • Synonyms
    MGC:36556
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446237
    NCBI Gene: 233405
  • Gene Overview
    MyGene.info: VPS33B
Location & Maps
more
  • Sequence Map
    Chr7:80269649-80291754 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22106 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.59 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VPS33B, VPS33B, late endosome and lysosome associated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS33B, VPS33B, late endosome and lysosome associated
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 26276
    neXtProt AC: NX_Q9H267

  • Chr Location
    15q26.1; chr15:90998416-91022621 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human VPS33B associations

Human Disease Mouse Models
       Arthrogryposis, Renal Dysfunction, and Cholestasis 1; ARCS1   OMIM: 208085
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Vps33b
  • Incidental Mutations
Mice homozygous for a conditional allele activated by an inducible cre exhibit dry scaly skin, thrombocytosis, abnormal alpha-granule development, extramedullary hematopoiesis, abnormal platelets and megakaryocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017577 VEGA Gene Model | MGI Sequence Detail 22106 C57BL/6J ±  kb
transcript OTTMUST00000042739 VEGA | MGI Sequence Detail 2574 Not Applicable  
polypeptide OTTMUSP00000019195 VEGA | MGI Sequence Detail 617 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    257 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017332 vacuolar protein sorting-associated protein 33B
  • InterPro Domains
    IPR027482 Sec1-like, domain 2
    IPR001619 Sec1-like protein
    IPR027121 Vacuolar protein sorting-associated protein 33
Molecular
Reagents
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  • All nucleic 25
    cDNA 25

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:99274 Gissen P, et al., Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Hum Mol Genet. 2005 May 15;14(10):1261-70
  • Latest
    J:222766 Bem D, et al., VPS33B regulates protein sorting into and maturation of alpha-granule progenitor organelles in mouse megakaryocytes. Blood. 2015 Jul 9;126(2):133-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory