About   Help   FAQ
Arhgef16 Gene Detail
Summary
  • Symbol
    Arhgef16
  • Name
    Rho guanine nucleotide exchange factor (GEF) 16
  • Synonyms
    Neuroblastoma
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446219
    NCBI Gene: 230972
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154278469-154300051 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446219
protein coding gene Chr4:154278469-154301676 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029195
protein coding gene Chr4:158540045-158566630 (-)
A/J MGP_AJ_G0029160
protein coding gene Chr4:151883118-151907532 (-)
AKR/J MGP_AKRJ_G0029108
protein coding gene Chr4:156031605-156054781 (-)
BALB/cJ MGP_BALBcJ_G0029176
protein coding gene Chr4:152353722-152376888 (-)
C3H/HeJ MGP_C3HHeJ_G0028897
protein coding gene Chr4:156567138-156591615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029625
protein coding gene Chr4:164207608-164234207 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026871
protein coding gene Chr4:144187189-144209549 (-)
CAST/EiJ MGP_CASTEiJ_G0028310
protein coding gene Chr4:153972225-153998067 (-)
CBA/J MGP_CBAJ_G0028859
protein coding gene Chr4:169142906-169166752 (-)
DBA/2J MGP_DBA2J_G0029008
protein coding gene Chr4:151912082-151935684 (-)
FVB/NJ MGP_FVBNJ_G0028972
protein coding gene Chr4:151116600-151141011 (-)
LP/J MGP_LPJ_G0029098
protein coding gene Chr4:158447528-158470775 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028999
protein coding gene Chr4:172049323-172078036 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029657
protein coding gene Chr4:156594432-156618865 (-)
PWK/PhJ MGP_PWKPhJ_G0028030
protein coding gene Chr4:148001626-148025773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027864
protein coding gene Chr4:150895015-150920560 (-)
WSB/EiJ MGP_WSBEiJ_G0028390
protein coding gene Chr4:156765221-156790963 (-)



Homology
more
  • Human Ortholog
    ARHGEF16, Rho guanine nucleotide exchange factor 16
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARHGEF16, Rho guanine nucleotide exchange factor 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEF16, NBR
  • Links
    NCBI Gene ID: 27237
    neXtProt AC: NX_Q5VV41
    UniProt: Q5VV41

  • Chr Location
    1p36.32; chr1:3454583-3481115 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 230972 NCBI Gene Model | MGI Sequence Detail 21583 C57BL/6J ±  kb
transcript NM_001112744 RefSeq | MGI Sequence Detail 2717 C57BL/6  
polypeptide Q3U5C8 UniProt | EBI | MGI Sequence Detail 713 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 2
    cDNA 58

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
  • Latest
    J:218482 Lee J, et al., Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Biochim Biophys Acta. 2014 Nov;1843(11):2438-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory