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Phf13 Gene Detail
Summary
  • Symbol
    Phf13
  • Name
    PHD finger protein 13
  • Synonyms
    SPOC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446217
    NCBI Gene: 230936
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:151989631-151996179 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446217
protein coding gene Chr4:151989631-151996258 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029166
protein coding gene Chr4:156080794-156087366 (-)
A/J MGP_AJ_G0029131
protein coding gene Chr4:149522027-149528652 (-)
AKR/J MGP_AKRJ_G0029079
protein coding gene Chr4:153604316-153610941 (-)
BALB/cJ MGP_BALBcJ_G0029147
protein coding gene Chr4:150008847-150015473 (-)
C3H/HeJ MGP_C3HHeJ_G0028868
protein coding gene Chr4:154166376-154173001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029596
protein coding gene Chr4:161669889-161676514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026842
protein coding gene Chr4:141890476-141897064 (-)
CAST/EiJ MGP_CASTEiJ_G0028281
protein coding gene Chr4:151500557-151506830 (-)
CBA/J MGP_CBAJ_G0028830
protein coding gene Chr4:166483354-166489979 (-)
DBA/2J MGP_DBA2J_G0028979
protein coding gene Chr4:149584192-149590817 (-)
FVB/NJ MGP_FVBNJ_G0028943
protein coding gene Chr4:148741647-148748272 (-)
LP/J MGP_LPJ_G0029069
protein coding gene Chr4:156000075-156006700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028970
protein coding gene Chr4:169528216-169534841 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029628
protein coding gene Chr4:154136140-154142766 (-)
PWK/PhJ MGP_PWKPhJ_G0028001
protein coding gene Chr4:145654660-145661003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027835
protein coding gene Chr4:148412296-148418884 (-)
WSB/EiJ MGP_WSBEiJ_G0028361
protein coding gene Chr4:154300409-154307037 (-)



Homology
more
  • Human Ortholog
    PHF13, PHD finger protein 13
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PHF13, PHD finger protein 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PHF5, SPOC1
  • Links
    NCBI Gene ID: 148479
    neXtProt AC: NX_Q86YI8
    UniProt: Q86YI8

  • Chr Location
    1p36.31; chr1:6613696-6624033 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17822
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PHF13
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced male fertility over time associated with impaired spermatogonial stem cell differentiation and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230936 NCBI Gene Model | MGI Sequence Detail 6549 C57BL/6J ±  kb
    transcript NM_172705 RefSeq | MGI Sequence Detail 3128 FVB/N  
    polypeptide Q8K2W6 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 55
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:247836 Frohns A, et al., Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization. Curr Biol. 2014 May 19;24(10):1080-90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory