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Dennd4b Gene Detail
Summary
  • Symbol
    Dennd4b
  • Name
    DENN/MADD domain containing 4B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446201
    NCBI Gene: 229541
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90265185-90280669 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446201
protein coding gene Chr3:90264923-90280669 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027460
protein coding gene Chr3:90561265-90576747 (+)
A/J MGP_AJ_G0027424
protein coding gene Chr3:87549167-87564772 (+)
AKR/J MGP_AKRJ_G0027389
protein coding gene Chr3:89696964-89712469 (+)
BALB/cJ MGP_BALBcJ_G0027433
protein coding gene Chr3:87508734-87524224 (+)
C3H/HeJ MGP_C3HHeJ_G0027175
protein coding gene Chr3:89864056-89879551 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027879
protein coding gene Chr3:93967263-93982759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025232
protein coding gene Chr3:83045705-83060993 (+)
CAST/EiJ MGP_CASTEiJ_G0026621
protein coding gene Chr3:90247807-90263164 (+)
CBA/J MGP_CBAJ_G0027150
protein coding gene Chr3:97204068-97219542 (+)
DBA/2J MGP_DBA2J_G0027287
protein coding gene Chr3:86918685-86934134 (+)
FVB/NJ MGP_FVBNJ_G0027255
protein coding gene Chr3:85255681-85271138 (+)
LP/J MGP_LPJ_G0027396
protein coding gene Chr3:91628997-91644475 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027276
protein coding gene Chr3:103403649-103419449 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027938
protein coding gene Chr3:89450214-89465696 (+)
PWK/PhJ MGP_PWKPhJ_G0026355
protein coding gene Chr3:86806900-86822523 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026175
protein coding gene Chr3:88622704-88640095 (+)
WSB/EiJ MGP_WSBEiJ_G0026703
protein coding gene Chr3:89842654-89858730 (+)



Homology
more
  • Human Ortholog
    DENND4B, DENN domain containing 4B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DENND4B, DENN domain containing 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0476
  • Links
    NCBI Gene ID: 9909
    neXtProt AC: NX_O75064
    UniProt: O75064

  • Chr Location
    1q21.3; chr1:153929501-153946681 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042404 Ensembl Gene Model | MGI Sequence Detail 15485 C57BL/6J ±  kb
transcript ENSMUST00000098914 Ensembl | MGI Sequence Detail 5423 Not Applicable  
polypeptide ENSMUSP00000096514 Ensembl | MGI Sequence Detail 1510 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory