Nup188 MGI Mouse Gene Detail - MGI:2446190

Symbol

Nup188
Name

nucleoporin 188
Synonyms

mKIAA0169

Feature Type

protein coding gene
IDs

MGI:2446190
NCBI Gene: 227699
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:30176419-30234278 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.49 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

1438 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446190	protein coding gene	Chr2:30176409-30234278 (+)
129S1/SvImJ	ENSMUSGG00200054398	protein coding gene	Chr2:27164702-27205118 (+)
129S1/SvImJ	ENSMUSG00200050258	protein coding gene	Chr2:27147256-27164673 (+)
A/J	ENSMUSG00195039521	protein coding gene	Chr2:27240640-27258050 (+)
A/J	ENSMUSGG00195055400	protein coding gene	Chr2:27258079-27298516 (+)
AKR/J	ENSMUSG00220049601	protein coding gene	Chr2:27359196-27376610 (+)
AKR/J	ENSMUSGG00220054319	protein coding gene	Chr2:27376639-27417072 (+)
BALB/cJ	ENSMUSGG00180054994	protein coding gene	Chr2:27277614-27318044 (+)
BALB/cJ	ENSMUSG00180053215	protein coding gene	Chr2:27260175-27277585 (+)
C3H/HeJ	ENSMUSGG00175055166	protein coding gene	Chr2:27246930-27287356 (+)
C3H/HeJ	ENSMUSG00175052784	protein coding gene	Chr2:27229493-27246901 (+)
C57BL/6NJ	ENSMUSG00215042114	protein coding gene	Chr2:27294915-27312333 (+)
C57BL/6NJ	ENSMUSGG00215055214	protein coding gene	Chr2:27312362-27352794 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023391	protein coding gene	Chr2:26149487-26207705 (+)
CAST/EiJ	ENSTCUGG00005053804	protein coding gene	Chr2:26980517-27020853 (+)
CBA/J	ENSMUSGG00210055112	protein coding gene	Chr2:27319860-27360293 (+)
CBA/J	ENSMUSG00210016914	protein coding gene	Chr2:27302418-27319831 (+)
DBA/2J	ENSMUSG00185044554	protein coding gene	Chr2:27154696-27172105 (+)
DBA/2J	ENSMUSGG00185057344	protein coding gene	Chr2:27172134-27212568 (+)
FVB/NJ	ENSMUSG00205042833	protein coding gene	Chr2:27006772-27024183 (+)
FVB/NJ	ENSMUSGG00205054631	protein coding gene	Chr2:27024212-27064648 (+)
JF1/MsJ	ENSUMUGG00000058732	protein coding gene	Chr2:27066280-27106893 (+)
LP/J	ENSMUSGG00230055299	protein coding gene	Chr2:29100403-29140816 (+)
LP/J	ENSMUSG00230043800	protein coding gene	Chr2:29082962-29100374 (+)
NOD/ShiLtJ	ENSMUSGG00190055100	protein coding gene	Chr2:27278876-27319305 (+)
NOD/ShiLtJ	ENSMUSG00190047424	protein coding gene	Chr2:27261435-27278847 (+)
NZO/HlLtJ	ENSMUSG00225008368	protein coding gene	Chr2:36832525-36849932 (+)
NZO/HlLtJ	ENSMUSGG00225055726	protein coding gene	Chr2:36849961-36890351 (+)
PWK/PhJ	ENSLUMG00010050301	protein coding gene	Chr2:27125378-27183609 (+)
SPRET/EiJ	ENSMSPG00010039796	protein coding gene	Chr2:27857619-27916277 (+)
WSB/EiJ	ENSIUOGG00005053865	protein coding gene	Chr2:27124477-27164888 (+)

Human Ortholog

NUP188, nucleoporin 188

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP188, nucleoporin 188
Synonyms

hNup188, KIAA0169, SANDSTEF
Links

HGNC:17859

NCBI Gene ID: 23511

UniProt: Q5SRE5
Chr Location

9q34.11; chr9:128947683-129007835 (+) GRCh38

MGI Vertebrate Homology

Nup188 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP188
Gene Tree

Nup188

Diseases

2 with human NUP188 associations

				Human Disease	Mouse Models
				respiratory failure IDs respiratory failure DOID:11162 DOID:11391 DOID:11392 DOID:11393 ICD10CM:J96.0 ICD9CM_2006:518.84 ICD9CM:518.81 NCI:C27043 UMLS_CUI:C0264490
				Sandestig-Stefanova syndrome IDs Sandestig-Stefanova syndrome DOID:0081272 OMIM:618804

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

8
Gene trapped

7
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

134

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup188

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All Sequences

84
RefSeq

15
UniProt

5
CCDS

CCDS15878.1

Ensembl

ENSMUSG00000052533 (Evidence)
NCBI Gene

227699

			Length	Strain/Species	Flank
genomic	227699	NCBI Gene Model \| MGI Sequence Detail	57860	C57BL/6J	± kb
transcript	NM_001410240	RefSeq \| MGI Sequence Detail	5737	C57BL/6
polypeptide	Q6ZQH8	UniProt \| EBI \| MGI Sequence Detail	1759	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011511 nucleoporin NUP188

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR044840 Nucleoporin Nup188

IPR018864 Nucleoporin Nup188, N-terminal

IPR048883 Nucleoporin Nup188, N-terminal subdomain III
GlyGen

Q6ZQH8 13 sites, 1 O-linked glycan (12 sites)

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All nucleic 134

cDNA 134

Microarray probesets 6

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MGI:1927640

Summaries

All 32

Gene Ontology 6

Phenotypes 5
Earliest

J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Nup188:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17105	Chr2:30176395-30176406 (+)	-18 bp
Tssr17106	Chr2:30176418-30176454 (+)	17 bp
Tssr17107	Chr2:30202639-30202663 (+)	26,232 bp
Tssr17108	Chr2:30212497-30212518 (+)	36,089 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24