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Eif2b5
Gene Detail
 Symbol
Name
ID
Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
MGI:2446176
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:20498817-20509955 bp, + strand
From VEGA annotation of GRCm38

  11139 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2903  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eif2b5

Human
homologs
Human Homolog EIF2B5, eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
NCBI Gene ID 8893
neXtProt AC  NX_Q13144
Human Synonyms  CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM
Human Chr (Location)  3q27.1; chr3:184135022-184145311 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2B5
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit abnormal brain white matter development, decreased body fat, demyelination, impaired recovery from cuprizone-induced demyelination, and impaired coordination.
 
Interactions
Eif2b5 interacts with 155 markers (Mir7-2, Mir7b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process astrocyte development, astrocyte differentiation, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex, ...
Function guanyl-nucleotide exchange factor activity, translation initiation factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) cDNA(76)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025977 (Evidence)
Ensembl Gene ModelENSMUSG00000003235 (Evidence)
Entrez Gene224045 (Evidence)
UniGene233855
DFCITC1578309, TC1638182
DoTSDT.40135228, DT.531792
NIA Mouse Gene IndexU016913
Consensus CDS ProjectCCDS28047.1
International Mouse Knockout Project StatusEif2b5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025977 VEGA Gene Model | MGI Sequence Detail 11139 C57BL/6J ±  kb
transcript OTTMUST00000064059 VEGA | MGI Sequence Detail 3186 Not Applicable 
polypeptide OTTMUSP00000031765 VEGA | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR001451 Bacterial transferase hexapeptide repeat
InterPro IPR016021 MIF4-like, type 1/2/3
InterPro IPR011004 Trimeric LpxA-like
InterPro IPR003307 W2 domain
Protein Ontology PR:000006966 translation initiation factor eIF-2B subunit epsilon
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:192103 Cabilly Y, et al., Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease. PLoS One. 2012;7(10):e46715
All references(39)
Other
accession IDs
MGI:2146712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory