Eif2b5
Gene Detail

Symbol Name ID

Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon MGI:2446176

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:20498817-20509955 bp, + strand From VEGA annotation of GRCm38   11139 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2903  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eif2b5

Human homologs

Human Homolog		EIF2B5, eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
NCBI Gene ID		8893
neXtProt AC		NX_Q13144
Human Synonyms		CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM
Human Chr (Location)		3q27.1; chr3:183852810-183863099 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EIF2B5

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a knock-in allele exhibit abnormal brain white matter development, decreased body fat, demyelination, impaired recovery from cuprizone-induced demyelination, and impaired coordination.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	astrocyte development, astrocyte differentiation, ...
Component	cytoplasm, eukaryotic translation initiation factor 2B complex, ...
Function	guanyl-nucleotide exchange factor activity, translation initiation factor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	41

cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(76)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000025977 (Evidence)
Ensembl Gene Model	ENSMUSG00000003235 (Evidence)
Entrez Gene	224045 (Evidence)
UniGene	233855
DFCI	TC1578309, TC1638182
DoTS	DT.40135228, DT.531792
NIA Mouse Gene Index	U016913
Consensus CDS Project	CCDS28047.1
International Mouse Knockout Project Status	Eif2b5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025977	VEGA Gene Model | MGI Sequence Detail	11139	C57BL/6J
transcript	OTTMUST00000064059	VEGA | MGI Sequence Detail	3186	Not Applicable
polypeptide	OTTMUSP00000031765	VEGA | MGI Sequence Detail	717	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR001451	Bacterial transferase hexapeptide repeat
InterPro	IPR016021	MIF4-like, type 1/2/3
InterPro	IPR011004	Trimeric LpxA-like
InterPro	IPR003307	W2 domain
Protein Ontology	PR:000006966	translation initiation factor eIF-2B subunit epsilon

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:192103 Cabilly Y, et al., Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease. PLoS One. 2012;7(10):e46715
All references(40)

Other accession IDs

MGI:2146712