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Eif2b5 Gene Detail
Summary
  • Symbol
    Eif2b5
  • Name
    eukaryotic translation initiation factor 2B, subunit 5 epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446176
    NCBI Gene: 224045
  • Gene Overview
    MyGene.info: EIF2B5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20498817-20509323 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446176
protein coding gene Chr16:20498810-20509955 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022642
protein coding gene Chr16:17835333-17848048 (+)
A/J MGP_AJ_G0022604
protein coding gene Chr16:16972901-16984747 (+)
AKR/J MGP_AKRJ_G0022579
protein coding gene Chr16:17623852-17635376 (+)
BALB/cJ MGP_BALBcJ_G0022608
protein coding gene Chr16:17130821-17142403 (+)
C3H/HeJ MGP_C3HHeJ_G0022373
protein coding gene Chr16:17778643-17791833 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023059
protein coding gene Chr16:18170589-18193040 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020576
protein coding gene Chr16:17665783-17676529 (+)
CAST/EiJ MGP_CASTEiJ_G0021903
protein coding gene Chr16:17756559-17770532 (+)
CBA/J MGP_CBAJ_G0022345
protein coding gene Chr16:18924697-18935755 (+)
DBA/2J MGP_DBA2J_G0022477
protein coding gene Chr16:16903617-16915432 (+)
FVB/NJ MGP_FVBNJ_G0022452
protein coding gene Chr16:16934486-16945539 (+)
LP/J MGP_LPJ_G0022544
protein coding gene Chr16:17561247-17575458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022472
protein coding gene Chr16:18614433-18625785 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023070
protein coding gene Chr16:17579713-17590773 (+)
PWK/PhJ MGP_PWKPhJ_G0021644
protein coding gene Chr16:17164974-17176429 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021473
protein coding gene Chr16:17386436-17397587 (+)
WSB/EiJ MGP_WSBEiJ_G0021947
protein coding gene Chr16:17570392-17581584 (+)



Homology
more
  • Human Ortholog
    EIF2B5, eukaryotic translation initiation factor 2B subunit epsilon
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2B5, eukaryotic translation initiation factor 2B subunit epsilon
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM
  • Links
    NCBI Gene ID: 8893
    neXtProt AC: NX_Q13144
    UniProt: Q13144

  • Chr Location
    3q27.1; chr3:184134435-184145311 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2903
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF2B5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Eif2b5 mouse models; 1 with human EIF2B5 associations

Human Disease Mouse Models
      
IDs
View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal brain white matter development, decreased body fat, demyelination, impaired recovery from cuprizone-induced demyelination, and impaired coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003235 Ensembl Gene Model | MGI Sequence Detail 10507 C57BL/6J ±  kb
    transcript ENSMUST00000003320 Ensembl | MGI Sequence Detail 2554 Not Applicable  
    polypeptide ENSMUSP00000003320 Ensembl | MGI Sequence Detail 717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 77

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146712
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Diseases 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:263833 Wisse LE, et al., Adult mouse eIF2Bepsilon Arg191His astrocytes display a normal integrated stress response in vitro. Sci Rep. 2018 Feb 28;8(1):3773

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory