Farp1 Gene Detail

Summary

• Symbol
  Farp1
• Name
  FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
• Synonyms
  Cdep

• Feature Type
  protein coding gene
• IDs
  MGI:2446173
  NCBI Gene: 223254
• Gene Overview
  MyGene.info: FARP1
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr14:121035200-121283744 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    248545 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, 64.86 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1

• Vertebrate Orthologs
  10

• Human Ortholog
  FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  CDEP, FARP1-IT1, PLEKHC2, PPP1R75
• Links
  HGNC:3591

  NCBI Gene ID: 10160

  neXtProt AC: NX_Q9Y4F1

  UniProt: Q9Y4F1

  
  
• Chr Location
  13q32.2; chr13:98142562-98449773 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 38098
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: FARP1
• Gene Tree
  Farp1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (other)
  1
• Gene trapped
  3
• Targeted
  3
• Genomic Mutations
  1 involving Farp1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  34 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  21
• GO References
  4

• External Resources
  FuncBase

Expression

• Assay Results
  42
• Tissues
  28
• cDNA Data
  142
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA FARP1
  Xenbase farp1

Interactions

• Farp1 interacts with 208 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  62
• RefSeq
  6
• UniProt
  8
• CCDS
  CCDS37015.1
• UniGene
  223980

• VEGA
  OTTMUSG00000026446 (Evidence)
• Ensembl
  ENSMUSG00000025555 (Evidence)
• NCBI Gene
  223254

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000026446	VEGA Gene Model | MGI Sequence Detail	248545	C57BL/6J
transcript	OTTMUST00000065407	VEGA | MGI Sequence Detail	4885	Not Applicable
polypeptide	OTTMUSP00000032599	VEGA | MGI Sequence Detail	1048	Not Applicable

Polymorphisms

• SNPs within 2kb
  2612 from dbSNP Build 142

Protein
Information

• UniProt
  8 Sequences
• InterPro Domains
  IPR019749 Band 4.1 domain
  IPR000219 Dbl homology (DH) domain
  IPR035899 Dbl homology (DH) domain superfamily
  IPR000798 Ezrin/radixin/moesin-like
  IPR014352 FERM/acyl-CoA-binding protein superfamily
  IPR014847 FERM adjacent (FA)
  IPR019748 FERM central domain
  IPR019747 FERM conserved site
  IPR018980 FERM, C-terminal PH-like domain
  IPR000299 FERM domain
  IPR018979 FERM, N-terminal
  IPR035963 FERM superfamily, second domain
  IPR011993 PH-like domain superfamily
  IPR001849 Pleckstrin homology domain
  IPR029071 Ubiquitin-like domain superfamily

Molecular
Reagents

• All nucleic 142

  cDNA 142

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2145808

References

• Summaries
  All 32

  Developmental Gene Expression 1

  Gene Ontology 4

  Phenotypes 8
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514