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Itpk1 Gene Detail
Summary
  • Symbol
    Itpk1
  • Name
    inositol 1,3,4-triphosphate 5/6 kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446159
    NCBI Gene: 217837
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102534842-102671128 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3761 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446159
 protein coding gene Chr12:102534841-102671189 (-)
129S1/SvImJ ENSMUSGG00200054933
 protein coding gene Chr12:94389994-94471533 (-)
129S1/SvImJ ENSMUSG00200025495
 protein coding gene Chr12:94354532-94372827 (-)
A/J ENSMUSGG00195054914
 protein coding gene Chr12:96916140-96997895 (-)
A/J ENSMUSG00195019978
 protein coding gene Chr12:96880649-96898972 (-)
AKR/J ENSMUSGG00220054627
 protein coding gene Chr12:94864389-94945933 (-)
AKR/J ENSMUSG00220034138
 protein coding gene Chr12:94828928-94847221 (-)
BALB/cJ ENSMUSGG00180055323
 protein coding gene Chr12:96110404-96191956 (-)
BALB/cJ ENSMUSG00180033541
 protein coding gene Chr12:96074939-96093236 (-)
C3H/HeJ ENSMUSGG00175054791
 protein coding gene Chr12:98728998-98810745 (-)
C3H/HeJ ENSMUSG00175032893
 protein coding gene Chr12:98693513-98711832 (-)
C57BL/6NJ ENSMUSG00215039059
 protein coding gene Chr12:95355540-95373844 (-)
C57BL/6NJ ENSMUSGG00215055772
 protein coding gene Chr12:95391011-95472561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018038
 protein coding gene Chr12:97220804-97357246 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054807
 protein coding gene Chr12:95763435-95844957 (-)
CBA/J ENSMUSG00210014740
 protein coding gene Chr12:95727973-95746268 (-)
DBA/2J ENSMUSG00185042982
 protein coding gene Chr12:97532803-97551093 (-)
DBA/2J ENSMUSGG00185057816
 protein coding gene Chr12:97568262-97649673 (-)
FVB/NJ ENSMUSGG00205054289
 protein coding gene Chr12:94781499-94863021 (-)
FVB/NJ ENSMUSG00205015241
 protein coding gene Chr12:94746040-94764332 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230027503
 protein coding gene Chr12:104619524-104637817 (-)
LP/J ENSMUSGG00230055575
 protein coding gene Chr12:104654984-104736522 (-)
NOD/ShiLtJ ENSMUSG00190022532
 protein coding gene Chr12:90391185-90409479 (+)
NOD/ShiLtJ ENSMUSGG00190054924
 protein coding gene Chr12:90292481-90374015 (+)
NZO/HlLtJ ENSMUSGG00225055477
 protein coding gene Chr12:106366017-106447548 (-)
NZO/HlLtJ ENSMUSG00225037527
 protein coding gene Chr12:106330553-106348849 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ITPK1, inositol-tetrakisphosphate 1-kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITPK1, inositol-tetrakisphosphate 1-kinase
  • Synonyms
    ITRPK1
  • Links
    NCBI Gene ID: 3705
    UniProt: Q13572

  • Chr Location
    14q32.12; chr14:92936914-93116458 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some mice homozygous for a gene trap allele exhibit neural tube defects (exencephaly and spina bifida), growth retardation, kyphoscoliosis, and rib formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    136
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217837 NCBI Gene Model | MGI Sequence Detail 136287 C57BL/6J ±  kb
    transcript NM_172584 RefSeq | MGI Sequence Detail 2856 C57BL/6  
    polypeptide Q8BYN3 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory