About   Help   FAQ
Pde2a
Gene Detail
Symbol

Name
ID
Pde2a
phosphodiesterase 2A, cGMP-stimulated
MGI:2446107
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:101421691-101512829 bp, + strand
From NCBI annotation of GRCm38

  91139 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase, cGMP-stimulated
Gene Tree: Pde2a

Human
homologs
Human Homolog PDE2A, phosphodiesterase 2A, cGMP-stimulated
NCBI Gene ID 5138
neXtProt AC  NX_O00408
Human Synonyms  cGSPDE, CGS-PDE, PDE2A1, PED2A4
Human Chr (Location)  11q13.4; chr11:72576140-72674453 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality between E17 and E18; another knock out mutation results in only some animals surviving to weaning age.
 
Interactions
Pde2a interacts with 203 markers (Mir18, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process cAMP catabolic process, cAMP-mediated signaling, ...
Component axon, cytoplasm, ...
Function 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (147)    Tissues (143)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 52
RNA in situ 95
cDNA source data(91)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(91) cDNA(91)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000030653 (Evidence)
Entrez Gene207728 (Evidence)
UniGene247564
DFCITC1757693, TC1672375, TC1605246, TC1578052
DoTSDT.97365795, DT.97343352, DT.110979859, DT.101175889, DT.101224212, DT.101348519, DT.101341032, DT.101288055
NIA Mouse Gene IndexU042845
EC3.1.4.17
PDB1MC0
Consensus CDS ProjectCCDS40043.1, CCDS52330.1
International Mouse Knockout Project StatusPde2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 207728 NCBI Gene Model | MGI Sequence Detail 91139 C57BL/6J ±  kb
transcript NM_001143848 RefSeq | MGI Sequence Detail 4220 C57BL/6 
polypeptide Q922S4 UniProt | EBI | MGI Sequence Detail 916 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(24) UniProt(15)
Polymorphisms
SNPs within 2kb(798 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR003018 GAF domain
InterPro IPR003607 HD/PDEase domain
Protein Ontology PR:000012469 cGMP-dependent 3',5'-cyclic phosphodiesterase
Graphical View of Protein Domain Structure
References
(Earliest) J:28665 Cherry JA, et al., A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons. J Neurobiol. 1995 Sep;28(1):102-13
(Latest) J:188507 Thumova M, et al., Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP. Am J Physiol Renal Physiol. 2012 Sep;303(6):F812-20
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory