About   Help   FAQ
Pde2a Gene Detail
Summary
  • Symbol
    Pde2a
  • Name
    phosphodiesterase 2A, cGMP-stimulated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446107
    NCBI Gene: 207728
  • Gene Overview
    MyGene.info: PDE2A
Location & Maps
more
  • Sequence Map
    Chr7:101421691-101512829 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91139 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PDE2A, phosphodiesterase 2A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PDE2A, phosphodiesterase 2A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    cGSPDE, CGS-PDE, PDE2A1, PED2A4
  • Links
    NCBI Gene ID: 5138
    neXtProt AC: NX_O00408

  • Chr Location
    11q13.4; chr11:72576140-72674453 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Pde2a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit lethality between E17 and E18; another knock out mutation results in only some animals surviving to weaning age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 207728 NCBI Gene Model | MGI Sequence Detail 91139 C57BL/6J ±  kb
transcript NM_001143848 RefSeq | MGI Sequence Detail 4220 C57BL/6  
polypeptide Q922S4 UniProt | EBI | MGI Sequence Detail 916 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    793 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000012469 cGMP-dependent 3',5'-cyclic phosphodiesterase
  • PDB
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003018 GAF domain
    IPR029016 GAF domain-like
    IPR003607 HD/PDEase domain
Molecular
Reagents
less
  • All nucleic 91
    cDNA 91

    Microarray probesets 7
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 15
    Phenotypes 12
  • Earliest
    J:28665 Cherry JA, et al., A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons. J Neurobiol. 1995 Sep;28(1):102-13
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory