Wnt9a
Gene Detail

Symbol Name ID

Wnt9a wingless-type MMTV integration site 9A MGI:2446084

Synonyms

Wnt14

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:59306928-59333552 bp, + strand From VEGA annotation of GRCm38   26625 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20722  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt9a

Human homologs

Human Homolog		WNT9A, wingless-type MMTV integration site family, member 9A
NCBI Gene ID		7483
neXtProt AC		NX_O14904
Human Synonyms		WNT14
Human Chr (Location)		1q42; chr1:228109165-228135676 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous inactivation of this gene results in neonatal lethality, altered chondrocyte maturation, cranial defects, and skeletal abnormalities including shortened appendicular long bones, partial joint fusions of carpal and tarsal elements, and chondroid metaplasia in synovial and fibrous joints.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	anatomical structure development, canonical Wnt receptor signaling pathway, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (233)    Tissues (205)    Images (40)
Theiler Stages: 5, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	216
RT-PCR	17

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(6) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005790 (Evidence)
Ensembl Gene Model	ENSMUSG00000000126 (Evidence)
Entrez Gene	216795 (Evidence)
UniGene	218794
DFCI	TC1582785, TC1599379
DoTS	DT.101721824
NIA Mouse Gene Index	U012680
Consensus CDS Project	CCDS36169.1
International Mouse Knockout Project Status	Wnt9a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005790	VEGA Gene Model | MGI Sequence Detail	26625	C57BL/6J
transcript	OTTMUST00000012816	VEGA | MGI Sequence Detail	3320	Not Applicable
polypeptide	OTTMUSP00000005960	VEGA | MGI Sequence Detail	365	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(120 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013303	Wnt-9a protein
InterPro	IPR026535	Wnt-9 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017452	protein Wnt-9a

References

(Earliest) J:76632 Katoh M, Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. Int J Mol Med. 2002 Mar;9(3):221-7
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(65)