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Smox Gene Detail
Summary
  • Symbol
    Smox
  • Name
    spermine oxidase
  • Synonyms
    B130066H01Rik, SMO
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445356
    NCBI Gene: 228608
  • Gene Overview
    MyGene.info: SMOX
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131491784-131525183 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445356
protein coding gene Chr2:131491496-131525922 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026531
protein coding gene Chr2:135031511-135065879 (+)
A/J MGP_AJ_G0026495
protein coding gene Chr2:129541520-129575920 (+)
AKR/J MGP_AKRJ_G0026470
protein coding gene Chr2:133274052-133309517 (+)
BALB/cJ MGP_BALBcJ_G0026507
protein coding gene Chr2:129930472-129964922 (+)
C3H/HeJ MGP_C3HHeJ_G0026250
protein coding gene Chr2:133737445-133772708 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026952
protein coding gene Chr2:139170042-139204550 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024329
protein coding gene Chr2:124278177-124313599 (+)
CAST/EiJ MGP_CASTEiJ_G0025711
protein coding gene Chr2:134006069-134047785 (+)
CBA/J MGP_CBAJ_G0026230
protein coding gene Chr2:144360970-144397997 (+)
DBA/2J MGP_DBA2J_G0026364
protein coding gene Chr2:128930483-128965887 (+)
FVB/NJ MGP_FVBNJ_G0026328
protein coding gene Chr2:127558373-127593216 (+)
LP/J MGP_LPJ_G0026469
protein coding gene Chr2:135251799-135288149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026348
protein coding gene Chr2:148173198-148210042 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027007
protein coding gene Chr2:133258478-133292856 (+)
PWK/PhJ MGP_PWKPhJ_G0025447
protein coding gene Chr2:128512453-128552525 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025249
protein coding gene Chr2:132414576-132453723 (+)
WSB/EiJ MGP_WSBEiJ_G0025785
protein coding gene Chr2:134161819-134197863 (+)



Homology
more
  • Human Ortholog
    SMOX, spermine oxidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SMOX, spermine oxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf16, PAO, PAO1, PAO-1, PAOH, PAOH1, SMO
  • Links
    NCBI Gene ID: 54498
    neXtProt AC: NX_Q9NWM0
    UniProt: Q9NWM0

  • Chr Location
    20p13; chr20:4148779-4187747 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69268
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMOX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
No notable phenotype was detected in a high-throughput screen of homozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228608 NCBI Gene Model | MGI Sequence Detail 33400 C57BL/6J ±  kb
transcript NM_001177833 RefSeq | MGI Sequence Detail 2280 C57BL/6  
polypeptide Q99K82 UniProt | EBI | MGI Sequence Detail 555 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 68
    cDNA 67
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2442763
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:218668 Bongers KS, et al., Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E144-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory