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Smox Gene Detail
Summary
  • Symbol
    Smox
  • Name
    spermine oxidase
  • Synonyms
    B130066H01Rik, SMO
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445356
    NCBI Gene: 228608
  • Gene Overview
    MyGene.info: SMOX
Location & Maps
more
  • Sequence Map
    Chr2:131491496-131525922 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34427 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SMOX, spermine oxidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SMOX, spermine oxidase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C20orf16, PAO, PAO1, PAO-1, PAOH, PAOH1, SMO
  • Links
    NCBI Gene ID: 54498
    neXtProt AC: NX_Q9NWM0

  • Chr Location
    20p13; chr20:4148779-4187747 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69268
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: SMOX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Smox
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016182 VEGA Gene Model | MGI Sequence Detail 34427 C57BL/6J ±  kb
transcript OTTMUST00000038754 VEGA | MGI Sequence Detail 2170 Not Applicable  
polypeptide OTTMUSP00000017330 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    212 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 66
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2442763
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:79984 Vujcic S, et al., Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002 Nov 1;367(Pt 3):665-75
  • Latest
    J:218668 Bongers KS, et al., Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E144-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory