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Cd109 Gene Detail
Summary
  • Symbol
    Cd109
  • Name
    CD109 antigen
  • Synonyms
    9930012E15Rik, Gov platelet alloantigens
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445221
    NCBI Gene: 235505
  • Gene Overview
    MyGene.info: CD109
Location & Maps
more
  • Sequence Map
    Chr9:78615546-78716253 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100708 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD109, CD109 molecule
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CD109, CD109 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CPAMD7, p180, r150
  • Links
    NCBI Gene ID: 135228
    neXtProt AC: NX_Q6YHK3

  • Chr Location
    6q13; chr6:73672182-73828317 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Cd109
  • Incidental Mutations
Mice homozygous for a null mutation display epidermal hyperplasia and thickening, sebaceous gland hyperplasia and transient impairment of hair growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036023 VEGA Gene Model | MGI Sequence Detail 100708 C57BL/6J ±  kb
transcript OTTMUST00000092445 VEGA | MGI Sequence Detail 5860 Not Applicable  
polypeptide OTTMUSP00000051097 VEGA | MGI Sequence Detail 1442 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    853 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001296 CD109 molecule
  • InterPro Domains
    IPR001599 Alpha-2-macroglobulin
    IPR019742 Alpha-2-macroglobulin, conserved site
    IPR002890 Alpha-2-macroglobulin, N-terminal
    IPR011625 Alpha-2-macroglobulin, N-terminal 2
    IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
    IPR011626 Alpha-macroglobulin complement component
    IPR009048 Alpha-macroglobulin, receptor-binding
    IPR014756 Immunoglobulin E-set
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Molecular
Reagents
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  • All nucleic 42
    cDNA 42

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143078
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:212214 Sakakura H, et al., Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice. PLoS One. 2014;9(1):e83385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory