Cd109
Gene Detail

Symbol Name ID

Cd109 CD109 antigen MGI:2445221

Synonyms

9930012E15Rik, Gov platelet alloantigens

Feature Type

protein coding gene

Genetic Map

Chromosome 9

43.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:78615546-78716253 bp, + strand From VEGA annotation of GRCm38   100708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:25183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Cd109

Human homologs

Human Homolog		CD109, CD109 molecule
NCBI Gene ID		135228
neXtProt AC		NX_Q6YHK3
Human Synonyms		CPAMD7, RP11-525G3.1
Human Chr (Location)		6q13; chr6:74405508-74538041 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a null mutation display epidermal hyperplasia and thickening, sebaceous gland hyperplasia and transient impairment of hair growth.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	negative regulation of peptidase activity
Component	anchored to membrane, extracellular region, ...
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(42)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036023 (Evidence)
Ensembl Gene Model	ENSMUSG00000046186 (Evidence)
Entrez Gene	235505 (Evidence)
UniGene	32955
DFCI	TC1580480, TC1614312
DoTS	DT.40174549, DT.97371380
NIA Mouse Gene Index	U010783
Consensus CDS Project	CCDS23365.1
International Mouse Knockout Project Status	Cd109

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036023	VEGA Gene Model | MGI Sequence Detail	100708	C57BL/6J
transcript	OTTMUST00000092445	VEGA | MGI Sequence Detail	5860	Not Applicable
polypeptide	OTTMUSP00000051097	VEGA | MGI Sequence Detail	1442	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(616 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology	PR:000001296	CD109 molecule

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:188696 Mii S, et al., Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109. Am J Pathol. 2012 Oct;181(4):1180-9
All references(34)

Other accession IDs

MGI:2143078