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Cd109
Gene Detail
Symbol

Name
ID
Cd109
CD109 antigen
MGI:2445221
Synonyms
9930012E15Rik, Gov platelet alloantigens
Feature Type
protein coding gene
Genetic Map
Chromosome 9
43.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:78615546-78716253 bp, + strand
From VEGA annotation of GRCm38

  100708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:25183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 western clawed frog; 1 zebrafish

HCOP human homology predictions: CD109
Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Cd109

Human
homologs
CD109, CD109 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 135228
neXtProt AC: NX_Q6YHK3

Human Synonyms: CPAMD7, p180, r150

Human Chr (Location): 6q13; chr6:73672182-73828317 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Cd109 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display epidermal hyperplasia and thickening, sebaceous gland hyperplasia and transient impairment of hair growth.
 
Interactions
Cd109 interacts with 226 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036023 (Evidence)
Ensembl Gene Model ENSMUSG00000046186 (Evidence)
Entrez Gene 235505 (Evidence)
UniGene 32955
DFCI TC1580480, TC1614312
DoTS DT.40174549, DT.97371380
NIA Mouse Gene Index U010783
Consensus CDS Project CCDS23365.1
International Mouse Phenotyping Consortium Status Cd109
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036023 VEGA Gene Model | MGI Sequence Detail 100708 C57BL/6J ±  kb
transcript OTTMUST00000092445 VEGA | MGI Sequence Detail 5860 Not Applicable 
polypeptide OTTMUSP00000051097 VEGA | MGI Sequence Detail 1442 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(857 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology PR:000001296 CD109 molecule
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:212214 Sakakura H, et al., Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice. PLoS One. 2014;9(1):e83385
All references(38)
Other
accession IDs
MGI:2143078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory