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Cd109 Gene Detail
Summary
  • Symbol
    Cd109
  • Name
    CD109 antigen
  • Synonyms
    9930012E15Rik, Gov platelet alloantigens
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445221
    NCBI Gene: 235505
  • Gene Overview
    MyGene.info: CD109
Location & Maps
more
  • Sequence Map
    Chr9:78615546-78716253 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100708 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CD109, CD109 molecule
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CD109, CD109 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPAMD7, p180, r150
  • Links
    NCBI Gene ID: 135228
    neXtProt AC: NX_Q6YHK3
    UniProt: Q6YHK3

  • Chr Location
    6q13; chr6:73679192-73828317 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display epidermal hyperplasia and thickening, sebaceous gland hyperplasia and transient impairment of hair growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036023 VEGA Gene Model | MGI Sequence Detail 100708 C57BL/6J ±  kb
transcript OTTMUST00000092445 VEGA | MGI Sequence Detail 5860 Not Applicable  
polypeptide OTTMUSP00000051097 VEGA | MGI Sequence Detail 1442 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    853 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 42

    Microarray probesets 4
Other
Accession IDs
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MGI:2143078
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:240045 Vorstenbosch J, et al., Overexpression of CD109 in the Epidermis Differentially Regulates ALK1 Versus ALK5 Signaling and Modulates Extracellular Matrix Synthesis in the Skin. J Invest Dermatol. 2017 Mar;137(3):641-649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory