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Cyp4f39 Gene Detail
Summary
  • Symbol
    Cyp4f39
  • Name
    cytochrome P450, family 4, subfamily f, polypeptide 39
  • Synonyms
    4732474A20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445210
    NCBI Gene: 320997
  • Gene Overview
    MyGene.info: CYP4F22
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32452723-32493320 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445210
protein coding gene Chr17:32452697-32493320 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023506
protein coding gene Chr17:32308703-32334148 (+)
A/J MGP_AJ_G0023463
protein coding gene Chr17:31235049-31259013 (+)
AKR/J MGP_AKRJ_G0023429
protein coding gene Chr17:31519719-31543750 (+)
BALB/cJ MGP_BALBcJ_G0023468
protein coding gene Chr17:31332520-31360086 (+)
C3H/HeJ MGP_C3HHeJ_G0023230
protein coding gene Chr17:31919301-31943902 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023911
protein coding gene Chr17:33397806-33421837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021385
protein coding gene Chr17:28336461-28360688 (+)
CAST/EiJ MGP_CASTEiJ_G0022731
protein coding gene Chr17:31976167-32001903 (+)
CBA/J MGP_CBAJ_G0023205
protein coding gene Chr17:34866282-34892484 (+)
DBA/2J MGP_DBA2J_G0023335
protein coding gene Chr17:30615188-30642874 (+)
FVB/NJ MGP_FVBNJ_G0023305
protein coding gene Chr17:30440636-30465758 (+)
LP/J MGP_LPJ_G0023413
protein coding gene Chr17:32524898-32549847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023323
protein coding gene Chr17:33934294-33958348 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023953
protein coding gene Chr17:31887402-31912010 (+)
PWK/PhJ MGP_PWKPhJ_G0022480
protein coding gene Chr17:29509211-29535993 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022299
protein coding gene Chr17:29902588-29926657 (+)
WSB/EiJ MGP_WSBEiJ_G0022793
protein coding gene Chr17:31876390-31901608 (+)



Homology
more
  • Human Ortholog
    CYP4F22, cytochrome P450 family 4 subfamily F member 22
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CYP4F22, cytochrome P450 family 4 subfamily F member 22
    Orthology source: HomoloGene
  • Synonyms
    ARCI5, INLNE, LI3
  • Links
    NCBI Gene ID: 126410
    neXtProt AC: NX_Q6NT55
    UniProt: Q6NT55

  • Chr Location
    19p13.12; chr19:15508487-15552317 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CYP4F22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete neonatal lethality associated with trans-epidermal water loss, persistent periderm, thin lipid lamella, thick corneocytes, and complete loss of acylceramide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061126 Ensembl Gene Model | MGI Sequence Detail 40598 C57BL/6J ±  kb
    transcript ENSMUST00000237491 Ensembl | MGI Sequence Detail 2618 Not Applicable  
    polypeptide ENSMUSP00000158442 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001128 Cytochrome P450
      IPR017972 Cytochrome P450, conserved site
      IPR002401 Cytochrome P450, E-class, group I
      IPR036396 Cytochrome P450 superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 19
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:286705 Miyamoto M, et al., Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production. J Invest Dermatol. 2020 Feb;140(2):319-326.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/20/2020
    MGI 6.16
    The Jackson Laboratory