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Tmem184b Gene Detail
Summary
  • Symbol
    Tmem184b
  • Name
    transmembrane protein 184b
  • Synonyms
    4732495E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445179
    NCBI Gene: 223693
  • Gene Overview
    MyGene.info: TMEM184B
Location & Maps
more
  • Sequence Map
    Chr15:79360684-79403303 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42620 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TMEM184B, transmembrane protein 184B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM184B, transmembrane protein 184B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C22orf5, FM08, HS5O6A, HSPC256
  • Links
    NCBI Gene ID: 25829
    neXtProt AC: NX_Q9Y519

  • Chr Location
    22q12; chr22:38216377-38273034 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    44
  • Chemically induced (other)
    1
  • Gene trapped
    39
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Tmem184b
  • Incidental Mutations
Mice homozygous for a gene-trapped allele exhibit delayed axon degeneration following peripheral nerve injury, progressive structural abnormalities at neuromuscular synapses, swellings within sensory terminals, sensory-motor dysfunction, and abnormal autophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 223693 NCBI Gene Model | MGI Sequence Detail 42620 C57BL/6J ±  kb
transcript NM_172608 RefSeq | MGI Sequence Detail 3388 C57BL/6  
polypeptide Q8BG09 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    387 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016419 transmembrane protein 184B
  • InterPro Domains
    IPR005178 Organic solute transporter subunit alpha/Transmembrane protein 184
Molecular
Reagents
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  • All nucleic 87
    cDNA 87

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Diseases 1
    Gene Ontology 2
    Phenotypes 29
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:231818 Bhattacharya MR, et al., TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. J Neurosci. 2016 Apr 27;36(17):4681-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory