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Timd4
Gene Detail
 Symbol
Name
ID
Timd4
T cell immunoglobulin and mucin domain containing 4
MGI:2445125
Synonyms B430010N18Rik, Tim4, TIM-4
Feature Type protein coding gene
Genetic Map
Chromosome 11
28.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:46810800-46844332 bp, + strand
From VEGA annotation of GRCm38

  33533 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51381  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Timd4

Human
homologs
Human Homolog TIMD4, T-cell immunoglobulin and mucin domain containing 4
NCBI Gene ID 91937
neXtProt AC  NX_Q96H15
Human Synonyms  SMUCKLER, TIM4
Human Chr (Location)  5q33.3; chr5:156919282-156963255 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired macrophage phagocytosis, altered macrophage physiology, and increased peritoneal lymphoid and meyloid cell numbers.
 
Interactions
Timd4 interacts with 176 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005508 (Evidence)
Ensembl Gene ModelENSMUSG00000055546 (Evidence)
Entrez Gene276891 (Evidence)
UniGene69002
DFCITC1584087
DoTSDT.94169744
NIA Mouse Gene IndexU012510
PDB3BIA, 3BIB, 3BI9
Consensus CDS ProjectCCDS36137.1
International Mouse Knockout Project StatusTimd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005508 VEGA Gene Model | MGI Sequence Detail 33533 C57BL/6J ±  kb
transcript OTTMUST00000012256 VEGA | MGI Sequence Detail 2173 Not Applicable 
polypeptide OTTMUSP00000005661 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(233 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000016339 T-cell immunoglobulin and mucin domain-containing protein 4
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:209302 Baghdadi M, et al., TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity. 2013 Dec 12;39(6):1070-81
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory