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Wdr41 Gene Detail
Summary
  • Symbol
    Wdr41
  • Name
    WD repeat domain 41
  • Synonyms
    B830029I03Rik, MSTP048
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445123
    NCBI Gene: 218460
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:94976344-95023314 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    401 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445123
protein coding gene Chr13:94976215-95023316 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020836
protein coding gene Chr13:96416701-96467758 (+)
A/J MGP_AJ_G0020790
protein coding gene Chr13:92804937-92852328 (+)
AKR/J MGP_AKRJ_G0020764
protein coding gene Chr13:95642174-95689023 (+)
BALB/cJ MGP_BALBcJ_G0020787
protein coding gene Chr13:93485492-93532681 (+)
C3H/HeJ MGP_C3HHeJ_G0020580
protein coding gene Chr13:95337440-95384256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021223
protein coding gene Chr13:99348451-99396140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018792
protein coding gene Chr13:88643447-88689147 (+)
CAST/EiJ MGP_CASTEiJ_G0020099
protein coding gene Chr13:94618653-94669656 (+)
CBA/J MGP_CBAJ_G0020539
protein coding gene Chr13:103291644-103346533 (+)
DBA/2J MGP_DBA2J_G0020664
protein coding gene Chr13:92591421-92638070 (+)
FVB/NJ MGP_FVBNJ_G0020645
protein coding gene Chr13:91378207-91424804 (+)
LP/J MGP_LPJ_G0020739
protein coding gene Chr13:96522093-96572439 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020673
protein coding gene Chr13:103746433-103795652 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021263
protein coding gene Chr13:95042515-95089265 (+)
PWK/PhJ MGP_PWKPhJ_G0019851
protein coding gene Chr13:91331177-91378366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019675
protein coding gene Chr13:91318577-91372045 (+)
WSB/EiJ MGP_WSBEiJ_G0020156
protein coding gene Chr13:95538596-95586216 (+)



Homology
more
  • Human Ortholog
    WDR41, WD repeat domain 41
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WDR41, WD repeat domain 41
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSTP048
  • Links
    NCBI Gene ID: 55255
    neXtProt AC: NX_Q9HAD4
    UniProt: Q9HAD4

  • Chr Location
    5q13.3-q14.1; chr5:77426652-77620611 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Wdr41
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for an ENU-generated allele exhibit increased susceptibility to DDS-induced colitis with increased activated single positive T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042015 Ensembl Gene Model | MGI Sequence Detail 46971 C57BL/6J ±  kb
transcript ENSMUST00000160115 Ensembl | MGI Sequence Detail 2851 Not Applicable  
polypeptide ENSMUSP00000138543 Ensembl | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:268243 McAlpine W, et al., Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11523-E11531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory