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Pisd Gene Detail
Summary
  • Symbol
    Pisd
  • Name
    phosphatidylserine decarboxylase
  • Synonyms
    9030221M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445114
    NCBI Gene: 320951
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:32893645-32942990 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1010 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445114
 protein coding gene Chr5:32893645-32943008 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029437
 protein coding gene Chr5:30850230-30919956 (-)
A/J MGP_AJ_G0029404
 protein coding gene Chr5:29902535-29924136 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029868
 protein coding gene Chr5:32726874-32778855 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027105
 protein coding gene Chr5:27458691-27505136 (-)
CAST/EiJ MGP_CASTEiJ_G0028545
 protein coding gene Chr5:30162651-30185433 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0029252
 protein coding gene Chr5:30067638-30113035 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0029337
 protein coding gene Chr5:31314791-31337682 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0028270
 protein coding gene Chr5:29196032-29218211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028101
 protein coding gene Chr5:29974796-30023349 (-)
WSB/EiJ MGP_WSBEiJ_G0028626
 protein coding gene Chr5:30625685-30650714 (-)



Homology
more
  • Human Ortholog
    PISD, phosphatidylserine decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PISD, phosphatidylserine decarboxylase
  • Synonyms
    DJ858B16, dJ858B16.2, LIBF, PSDC, PSSC
  • Links
    NCBI Gene ID: 23761
    UniProt: Q9UG56

  • Chr Location
    22q12.2; chr22:31618489-31662564 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Pisd
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    26 strains or lines available
Mice homozygous for a null mutation in this gene display embryogenesis defects such as abnormal trophoblast development, abnormal extraembronic tissue morphology and abnormal mitochondrial morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    130
  • cDNA Data
    125
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023452 Ensembl Gene Model | MGI Sequence Detail 49346 C57BL/6J ±  kb
transcript ENSMUST00000061895 Ensembl | MGI Sequence Detail 2183 Not Applicable  
polypeptide ENSMUSP00000051438 Ensembl | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 130
    cDNA 126
    Primer pair 2
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 68
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 12
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:352750 Johnson JM, et al., Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Sci Adv. 2023 Feb 24;9(8):eade7864
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory