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Zdhhc17 Gene Detail
Summary
  • Symbol
    Zdhhc17
  • Name
    zinc finger, DHHC domain containing 17
  • Synonyms
    A230053P19Rik, D130071N24Rik, Hip14, mKIAA0946
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445110
    NCBI Gene: 320150
  • Gene Overview
    MyGene.info: ZDHHC17
Location & Maps
more
  • Sequence Map
    Chr10:110941782-111010066 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68285 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 57.86 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZDHHC17, zinc finger DHHC-type containing 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZDHHC17, zinc finger DHHC-type containing 17
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HIP14, HIP3, HSPC294, HYPH
  • Links
    NCBI Gene ID: 23390
    neXtProt AC: NX_Q8IUH5

  • Chr Location
    12q21.2; chr12:76764074-76853701 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Zdhhc17 mouse models

Human Disease Mouse Models
       Huntington Disease; HD   OMIM: 143100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    1
  • Genomic Mutations
    1 involving Zdhhc17
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reminiscent of Huntington disease (decreased body weight, impaired coordination, hyperactivity, increased rearing, decreased prepulse inhibition, increased stereotypic behavior, reduced striatum, and decreased brain weight).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035798 Ensembl Gene Model | MGI Sequence Detail 68285 C57BL/6J ±  kb
transcript ENSMUST00000041723 Ensembl | MGI Sequence Detail 4546 Not Applicable  
polypeptide ENSMUSP00000043279 Ensembl | MGI Sequence Detail 632 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    753 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    cDNA 84
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2143904, MGI:2443485
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:233660 Lemonidis K, et al., Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases. J Biol Chem. 2015 Sep 4;290(36):21939-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory