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Plekha7 Gene Detail
Summary
  • Symbol
    Plekha7
  • Name
    pleckstrin homology domain containing, family A member 7
  • Synonyms
    A430081P20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445094
    NCBI Gene: 233765
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:116123485-116308376 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 61.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1843 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445094
protein coding gene Chr7:116123485-116308383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032889
protein coding gene Chr7:119853728-120051638 (-)
A/J MGP_AJ_G0032872
protein coding gene Chr7:116839782-117027409 (-)
AKR/J MGP_AKRJ_G0032804
protein coding gene Chr7:119774982-119976183 (-)
BALB/cJ MGP_BALBcJ_G0032877
protein coding gene Chr7:116549391-116767936 (-)
C3H/HeJ MGP_C3HHeJ_G0032587
protein coding gene Chr7:119733686-119929358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033383
protein coding gene Chr7:124652771-124852670 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030355
protein coding gene Chr7:118358791-118546635 (-)
CAST/EiJ MGP_CASTEiJ_G0031915
protein coding gene Chr7:111421760-111621096 (-)
CBA/J MGP_CBAJ_G0032560
protein coding gene Chr7:128778611-128988687 (-)
DBA/2J MGP_DBA2J_G0032712
protein coding gene Chr7:114893283-115079663 (-)
FVB/NJ MGP_FVBNJ_G0032665
protein coding gene Chr7:114738830-114931429 (-)
LP/J MGP_LPJ_G0032806
protein coding gene Chr7:121334975-121535589 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032697
protein coding gene Chr7:130395881-130599800 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033403
protein coding gene Chr7:118789405-118983684 (-)
PWK/PhJ MGP_PWKPhJ_G0031623
protein coding gene Chr7:107767562-107957487 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031470
protein coding gene Chr7:105506129-105724609 (-)
WSB/EiJ MGP_WSBEiJ_G0032028
protein coding gene Chr7:119665230-119863057 (-)



Homology
more
  • Human Ortholog
    PLEKHA7, pleckstrin homology domain containing A7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEKHA7, pleckstrin homology domain containing A7
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 144100
    neXtProt AC: NX_Q6IQ23
    UniProt: Q6IQ23

  • Chr Location
    11p15.2-p15.1; chr11:16787153-17014423 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show decreased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045659 Ensembl Gene Model | MGI Sequence Detail 184892 C57BL/6J ±  kb
transcript ENSMUST00000181998 Ensembl | MGI Sequence Detail 5149 Not Applicable  
polypeptide ENSMUSP00000138575 Ensembl | MGI Sequence Detail 1266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141928
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:234192 Guerrera D, et al., PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. J Biol Chem. 2016 May 20;291(21):11016-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory