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Lacc1 Gene Detail
Summary
  • Symbol
    Lacc1
  • Name
    laccase domain containing 1
  • Synonyms
    9030625A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445077
    NCBI Gene: 210808
  • Gene Overview
    MyGene.info: LACC1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:77024200-77036904 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 40.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445077
protein coding gene Chr14:77024200-77036952 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021582
protein coding gene Chr14:72008560-72029369 (-)
A/J MGP_AJ_G0021540
protein coding gene Chr14:70313398-70327735 (-)
AKR/J MGP_AKRJ_G0021517
protein coding gene Chr14:72406766-72419472 (-)
BALB/cJ MGP_BALBcJ_G0021547
protein coding gene Chr14:70116019-70129135 (-)
C3H/HeJ MGP_C3HHeJ_G0021324
protein coding gene Chr14:72122530-72135714 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021987
protein coding gene Chr14:75120074-75134979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019525
protein coding gene Chr14:67902443-67917403 (-)
CAST/EiJ MGP_CASTEiJ_G0020841
protein coding gene Chr14:68863140-68878207 (-)
CBA/J MGP_CBAJ_G0021292
protein coding gene Chr14:77553259-77566098 (-)
DBA/2J MGP_DBA2J_G0021415
protein coding gene Chr14:69702300-69715672 (-)
FVB/NJ MGP_FVBNJ_G0021393
protein coding gene Chr14:69051216-69064400 (-)
LP/J MGP_LPJ_G0021485
protein coding gene Chr14:73142557-73157147 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021420
protein coding gene Chr14:76208114-76221299 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022010
protein coding gene Chr14:71690560-71704966 (-)
PWK/PhJ MGP_PWKPhJ_G0020584
protein coding gene Chr14:66485022-66498991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020421
protein coding gene Chr14:67674046-67689516 (-)
WSB/EiJ MGP_WSBEiJ_G0020894
protein coding gene Chr14:72038617-72051325 (-)



Homology
more
  • Human Ortholog
    LACC1, laccase domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LACC1, laccase domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C13orf31, FAMIN
  • Links
    NCBI Gene ID: 144811
    neXtProt AC: NX_Q8IV20
    UniProt: Q8IV20

  • Chr Location
    13q14.11; chr13:43878834-43893932 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17712
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LACC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lacc1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit decreased fatty acid oxidation and glycolysis in macrophages and increased susceptibility to LPS-induced endotoxin shock.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044350 Ensembl Gene Model | MGI Sequence Detail 12705 C57BL/6J ±  kb
transcript ENSMUST00000062789 Ensembl | MGI Sequence Detail 2444 Not Applicable  
polypeptide ENSMUSP00000059173 Ensembl | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030799 laccase domain-containing protein 1
  • InterPro Domains
    IPR011324 Cytotoxic necrotizing factor-like, catalytic
    IPR003730 Multi-copper polyphenol oxidoreductase
    IPR038371 Multi-copper polyphenol oxidoreductase superfamily
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:270035 Skon-Hegg C, et al., LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation. J Immunol. 2019 Jan 1;202(1):183-193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory