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Lacc1 Gene Detail
Summary
  • Symbol
    Lacc1
  • Name
    laccase domain containing 1
  • Synonyms
    9030625A04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445077
    NCBI Gene: 210808
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:77261640-77274344 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 40.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445077
protein coding gene Chr14:77261640-77274344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021582
protein coding gene Chr14:72008560-72029369 (-)
A/J MGP_AJ_G0021540
protein coding gene Chr14:70313398-70327735 (-)
AKR/J MGP_AKRJ_G0021517
protein coding gene Chr14:72406766-72419472 (-)
BALB/cJ MGP_BALBcJ_G0021547
protein coding gene Chr14:70116019-70129135 (-)
C3H/HeJ MGP_C3HHeJ_G0021324
protein coding gene Chr14:72122530-72135714 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021987
protein coding gene Chr14:75120074-75134979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019525
protein coding gene Chr14:67902443-67917403 (-)
CAST/EiJ MGP_CASTEiJ_G0020841
protein coding gene Chr14:68863140-68878207 (-)
CBA/J MGP_CBAJ_G0021292
protein coding gene Chr14:77553259-77566098 (-)
DBA/2J MGP_DBA2J_G0021415
protein coding gene Chr14:69702300-69715672 (-)
FVB/NJ MGP_FVBNJ_G0021393
protein coding gene Chr14:69051216-69064400 (-)
LP/J MGP_LPJ_G0021485
protein coding gene Chr14:73142557-73157147 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021420
protein coding gene Chr14:76208114-76221299 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022010
protein coding gene Chr14:71690560-71704966 (-)
PWK/PhJ MGP_PWKPhJ_G0020584
protein coding gene Chr14:66485022-66498991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020421
protein coding gene Chr14:67674046-67689516 (-)
WSB/EiJ MGP_WSBEiJ_G0020894
protein coding gene Chr14:72038617-72051325 (-)



Homology
more
  • Human Ortholog
    LACC1, laccase domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LACC1, laccase domain containing 1
  • Synonyms
    C13orf31, FAMIN, JUVAR
  • Links
    NCBI Gene ID: 144811
    neXtProt AC: NX_Q8IV20
    UniProt: Q8IV20

  • Chr Location
    13q14.11; chr13:43879178-43893932 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LACC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased fatty acid oxidation and glycolysis in macrophages and increased susceptibility to LPS-induced endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210808 NCBI Gene Model | MGI Sequence Detail 12705 C57BL/6J ±  kb
    transcript NM_172488 RefSeq | MGI Sequence Detail 2419 C57BL/6  
    polypeptide Q8BZT9 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339910 Wei Z, et al., LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Nature. 2022 Sep;609(7926):348-353

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory