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Hmbox1 Gene Detail
Summary
  • Symbol
    Hmbox1
  • Name
    homeobox containing 1
  • Synonyms
    F830020C16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445066
    NCBI Gene: 219150
  • Gene Overview
    MyGene.info: HMBOX1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:64811600-64949871 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 33.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445066
protein coding gene Chr14:64811600-64949905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021474
protein coding gene Chr14:59391302-59531626 (-)
A/J MGP_AJ_G0021433
protein coding gene Chr14:58028140-58166791 (-)
AKR/J MGP_AKRJ_G0021409
protein coding gene Chr14:60055262-60193132 (-)
BALB/cJ MGP_BALBcJ_G0021439
protein coding gene Chr14:57974745-58113228 (-)
C3H/HeJ MGP_C3HHeJ_G0021216
protein coding gene Chr14:59702604-59839524 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021878
protein coding gene Chr14:62167616-62311275 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019418
protein coding gene Chr14:55966374-56102839 (-)
CAST/EiJ MGP_CASTEiJ_G0020733
protein coding gene Chr14:56183331-56320156 (-)
CBA/J MGP_CBAJ_G0021183
protein coding gene Chr14:64034602-64176748 (-)
DBA/2J MGP_DBA2J_G0021306
protein coding gene Chr14:57687902-57826118 (-)
FVB/NJ MGP_FVBNJ_G0021285
protein coding gene Chr14:57086469-57221892 (-)
LP/J MGP_LPJ_G0021381
protein coding gene Chr14:60428012-60571319 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021314
protein coding gene Chr14:63183408-63326919 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021901
protein coding gene Chr14:59229222-59366682 (-)
PWK/PhJ MGP_PWKPhJ_G0020477
protein coding gene Chr14:54390431-54531807 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020310
protein coding gene Chr14:55196939-55335808 (-)
WSB/EiJ MGP_WSBEiJ_G0020786
protein coding gene Chr14:59545112-59685544 (-)



Homology
more
  • Human Ortholog
    HMBOX1, homeobox containing 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HMBOX1, homeobox containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HNF1LA, HOT1, PBHNF
  • Links
    NCBI Gene ID: 79618
    neXtProt AC: NX_Q6NT76
    UniProt: Q6NT76

  • Chr Location
    8p21.1-p12; chr8:28890370-29064939 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11589
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HMBOX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit absence of TERT binding to chromatin as shown by subcellular fractionation analysis of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021972 Ensembl Gene Model | MGI Sequence Detail 138272 C57BL/6J ±  kb
transcript ENSMUST00000177326 Ensembl | MGI Sequence Detail 1729 Not Applicable  
polypeptide ENSMUSP00000135372 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR001387 Cro/C1-type helix-turn-helix domain
    IPR006899 Hepatocyte nuclear factor 1, N-terminal
    IPR001356 Homeobox domain
    IPR009057 Homeobox-like domain superfamily
    IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGI:2145656, MGI:2145678
References
more
  • Summaries
    All 37
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory