Slc25a21 MGI Mouse Gene Detail - MGI:2445059 - solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

Symbol

Slc25a21
Name

solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms

9930033G19Rik

Feature Type

protein coding gene
IDs

MGI:2445059
NCBI Gene: 217593
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr12:56759419-57244257 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 24.54 cM
Mapping Data

2 experiments

SNPs within 2kb

14048 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445059	protein coding gene	Chr12:56759419-57244257 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019758	protein coding gene	Chr12:55841918-56355752 (-)
A/J	MGP_AJ_G0019717	protein coding gene	Chr12:53807277-54286859 (-)
AKR/J	MGP_AKRJ_G0019692	protein coding gene	Chr12:55506724-56006099 (-)
BALB/cJ	MGP_BALBcJ_G0019697	protein coding gene	Chr12:54155714-54649835 (-)
C3H/HeJ	MGP_C3HHeJ_G0019502	protein coding gene	Chr12:55573490-56073970 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020149	protein coding gene	Chr12:57500827-58018135 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017769	protein coding gene	Chr12:52271104-52745121 (-)
CAST/EiJ	MGP_CASTEiJ_G0019054	protein coding gene	Chr12:50473272-50989674 (-)
CBA/J	MGP_CBAJ_G0019471	protein coding gene	Chr12:59509641-60068587 (-)
DBA/2J	MGP_DBA2J_G0019587	protein coding gene	Chr12:53709188-54200010 (-)
FVB/NJ	MGP_FVBNJ_G0019575	protein coding gene	Chr12:53013554-53496204 (-)
LP/J	MGP_LPJ_G0019659	protein coding gene	Chr12:55813894-56321073 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019613	protein coding gene	Chr12:61070896-61613767 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020183	protein coding gene	Chr12:54946248-55454786 (-)
PWK/PhJ	MGP_PWKPhJ_G0018821	protein coding gene	Chr12:48081375-48582364 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018614	protein coding gene	Chr12:49388738-49878344 (-)
WSB/EiJ	MGP_WSBEiJ_G0019105	protein coding gene	Chr12:55474237-55982625 (-)

Human Ortholog

SLC25A21, solute carrier family 25 member 21

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A21, solute carrier family 25 member 21
Synonyms

MTDPS18, ODC, ODC1
Links

HGNC:14411

NCBI Gene ID: 89874

UniProt: Q9BQT8
Chr Location

14q13.3; chr14:36677921-37172606 (-) GRCh38

MGI Vertebrate Homology

Slc25a21 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A21
Gene Tree

Slc25a21

Diseases

1 with human SLC25A21 associations

				Human Disease	Mouse Models
				mitochondrial DNA depletion syndrome 18 IDs mitochondrial DNA depletion syndrome 18 DOID:0070449 OMIM:618811

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

6
Transposon induced

1
Genomic Mutations

1 involving Slc25a21
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

879
Tissues

124
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a21

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS25925.1, CCDS49069.1

Ensembl

ENSMUSG00000035472 (Evidence)
NCBI Gene

217593

			Length	Strain/Species	Flank
genomic	217593	NCBI Gene Model \| MGI Sequence Detail	484839	C57BL/6J	± kb
transcript	NM_172577	RefSeq \| MGI Sequence Detail	2609	C57BL/6
polypeptide	Q8BZ09	UniProt \| EBI \| MGI Sequence Detail	298	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015017 mitochondrial 2-oxodicarboxylate carrier

(term hierarchy)
InterPro Domains

IPR051752 Mitochondrial 2-oxodicarboxylate carrier

IPR023395 Mitochondrial carrier domain superfamily

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 2

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MGI:2145073

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 15
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116422	Chr12:57244096-57244115 (-)	151 bp
Tssr116421	Chr12:57244076-57244090 (-)	174 bp
Tssr116420	Chr12:57244047-57244060 (-)	203 bp
Tssr116419	Chr12:57243980-57244045 (-)	244 bp
Tssr116418	Chr12:57243951-57243977 (-)	293 bp
Tssr116417	Chr12:57228238-57228246 (-)	16,015 bp
Tssr116416	Chr12:57222873-57222876 (-)	21,382 bp
Tssr116415	Chr12:57197913-57197917 (-)	46,342 bp
Tssr116414	Chr12:57164416-57164419 (-)	79,839 bp
Tssr116413	Chr12:57151288-57151295 (-)	92,965 bp
Tssr116412	Chr12:57054609-57054610 (-)	189,647 bp
Tssr116411	Chr12:57025485-57025488 (-)	218,770 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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