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Slc25a21 Gene Detail
Summary
  • Symbol
    Slc25a21
  • Name
    solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
  • Synonyms
    9930033G19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445059
    NCBI Gene: 217593
  • Gene Overview
    MyGene.info: SLC25A21
Location & Maps
more
  • Sequence Map
    Chr12:56712634-57197472 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      484839 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC25A21, solute carrier family 25 member 21
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC25A21, solute carrier family 25 member 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ODC, ODC1
  • Links
    NCBI Gene ID: 89874
    neXtProt AC: NX_Q9BQT8

  • Chr Location
    14q11.2; chr14:36677318-37172660 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Slc25a21
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023139 VEGA Gene Model | MGI Sequence Detail 484839 C57BL/6J ±  kb
transcript OTTMUST00000055919 VEGA | MGI Sequence Detail 2609 Not Applicable  
polypeptide OTTMUSP00000026828 VEGA | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3254 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015017 mitochondrial 2-oxodicarboxylate carrier
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145073
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:215078 Maguire S, et al., Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PLoS One. 2014;9(3):e91807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory