Slc25a21 MGI Mouse Gene Detail - MGI:2445059 - solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

Slc25a21 Gene Detail

Symbol

Slc25a21
Name

solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms

9930033G19Rik

Feature Type

protein coding gene
IDs

MGI:2445059
NCBI Gene: 217593
Gene Overview

MyGene.info: SLC25A21

Sequence Map

Chr12:56712634-57197472 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

484839 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 24.54 cM
Mapping Data

2 experiments

Human Ortholog

SLC25A21, solute carrier family 25 member 21

Vertebrate Orthologs

10

Human Ortholog

SLC25A21, solute carrier family 25 member 21
Orthology source: HomoloGene, HGNC
Synonyms

ODC, ODC1
Links

HGNC:14411

NCBI Gene ID: 89874

neXtProt AC: NX_Q9BQT8
Chr Location

14q11.2; chr14:36677318-37172660 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 6988
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SLC25A21
Gene Tree

Slc25a21

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Targeted

6
Genomic Mutations

1 involving Slc25a21
Incidental Mutations

Mutagenetix , APF

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All GO Annotations

7
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

115
Tissues

95
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase slc25a21

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Slc25a21 interacts with 181 markers (Mir7-1, Mir16-2, Mir19a, ...) View All

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All Sequences

31
RefSeq

4
UniProt

3
CCDS

CCDS25925.1, CCDS49069.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023139	VEGA Gene Model \| MGI Sequence Detail	484839	C57BL/6J	± kb
transcript	OTTMUST00000055919	VEGA \| MGI Sequence Detail	2609	Not Applicable
polypeptide	OTTMUSP00000026828	VEGA \| MGI Sequence Detail	298	Not Applicable

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SNPs within 2kb

3254 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000015017 mitochondrial 2-oxodicarboxylate carrier
InterPro Domains

IPR023395 Mitochondrial carrier domain

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 10

cDNA 10

Microarray probesets 2

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MGI:2145073

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:215078 Maguire S, et al., Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PLoS One. 2014;9(3):e91807

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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