Slc25a21 MGI Mouse Gene Detail - MGI:2445059 - solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

Symbol

Slc25a21
Name

solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Synonyms

9930033G19Rik

Feature Type

protein coding gene
IDs

MGI:2445059
NCBI Gene: 217593
Gene Overview

MyGene.info: SLC25A21
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:56712634-57197472 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 24.54 cM
Mapping Data

2 experiments

SNPs within 2kb

3254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445059	protein coding gene	Chr12:56712634-57197472 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019758	protein coding gene	Chr12:55841918-56355752 (-)
A/J	MGP_AJ_G0019717	protein coding gene	Chr12:53807277-54286859 (-)
AKR/J	MGP_AKRJ_G0019692	protein coding gene	Chr12:55506724-56006099 (-)
BALB/cJ	MGP_BALBcJ_G0019697	protein coding gene	Chr12:54155714-54649835 (-)
C3H/HeJ	MGP_C3HHeJ_G0019502	protein coding gene	Chr12:55573490-56073970 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020149	protein coding gene	Chr12:57500827-58018135 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017769	protein coding gene	Chr12:52271104-52745121 (-)
CAST/EiJ	MGP_CASTEiJ_G0019054	protein coding gene	Chr12:50473272-50989674 (-)
CBA/J	MGP_CBAJ_G0019471	protein coding gene	Chr12:59509641-60068587 (-)
DBA/2J	MGP_DBA2J_G0019587	protein coding gene	Chr12:53709188-54200010 (-)
FVB/NJ	MGP_FVBNJ_G0019575	protein coding gene	Chr12:53013554-53496204 (-)
LP/J	MGP_LPJ_G0019659	protein coding gene	Chr12:55813894-56321073 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019613	protein coding gene	Chr12:61070896-61613767 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020183	protein coding gene	Chr12:54946248-55454786 (-)
PWK/PhJ	MGP_PWKPhJ_G0018821	protein coding gene	Chr12:48081375-48582364 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018614	protein coding gene	Chr12:49388738-49878344 (-)
WSB/EiJ	MGP_WSBEiJ_G0019105	protein coding gene	Chr12:55474237-55982625 (-)

Human Ortholog

SLC25A21, solute carrier family 25 member 21

Vertebrate Orthologs

10

Human Ortholog

SLC25A21, solute carrier family 25 member 21
Orthology source: HomoloGene, HGNC
Synonyms

MTDPS18, ODC, ODC1
Links

HGNC:14411

NCBI Gene ID: 89874

neXtProt AC: NX_Q9BQT8

UniProt: Q9BQT8
Chr Location

14q13.3; chr14:36677921-37172660 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 6988
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SLC25A21
Gene Tree

Slc25a21

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Targeted

6
Genomic Mutations

1 involving Slc25a21
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

95
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a21

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Slc25a21 interacts with 181 markers (Mir7-1, Mir16-2, Mir19a, ...) View All

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All Sequences

46
RefSeq

4
UniProt

3
CCDS

CCDS25925.1, CCDS49069.1

Ensembl

ENSMUSG00000035472 (Evidence)
NCBI Gene

217593

			Length	Strain/Species	Flank
genomic	217593	NCBI Gene Model \| MGI Sequence Detail	484839	C57BL/6J	± kb
transcript	NM_172577	RefSeq \| MGI Sequence Detail	2609	C57BL/6
polypeptide	Q8BZ09	UniProt \| EBI \| MGI Sequence Detail	298	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015017 mitochondrial 2-oxodicarboxylate carrier

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 11

cDNA 11

Microarray probesets 2

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MGI:2145073

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Slc25a21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116422	Chr12:57197311-57197330 (-)	151 bp
Tssr116421	Chr12:57197291-57197305 (-)	174 bp
Tssr116420	Chr12:57197262-57197275 (-)	203 bp
Tssr116419	Chr12:57197195-57197260 (-)	244 bp
Tssr116418	Chr12:57197166-57197192 (-)	293 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/10/2020 MGI 6.16