Ccbe1
Gene Detail

Symbol Name ID

Ccbe1 collagen and calcium binding EGF domains 1 MGI:2445053

Synonyms

4933426F18Rik, 9430093N24Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

39.13 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:66045302-66302739 bp, - strand From VEGA annotation of GRCm38   257438 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ccbe1

Human homologs

Human Homolog		CCBE1, collagen and calcium binding EGF domains 1
NCBI Gene ID		147372
neXtProt AC		NX_Q6UXH8
Human Chr (Location)		18q21.32; chr18:57098171-57364644 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CCBE1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knock-out allele exhibit prenatal lethality associated with edema and absence of lymphatic vessels.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	angiogenesis, lymphangiogenesis, ...
Component	collagen, extracellular matrix, ...
Function	calcium ion binding, collagen binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000028218 (Evidence)
Ensembl Gene Model	ENSMUSG00000046318 (Evidence)
Entrez Gene	320924 (Evidence)
UniGene	442049
DFCI	TC1587060, TC1593703, TC1594494, TC1659528, TC1693025
NIA Mouse Gene Index	U038507
Consensus CDS Project	CCDS29314.1
International Mouse Knockout Project Status	Ccbe1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028218	VEGA Gene Model | MGI Sequence Detail	257438	C57BL/6J
transcript	OTTMUST00000069908	VEGA | MGI Sequence Detail	1631	Not Applicable
polypeptide	OTTMUSP00000035567	VEGA | MGI Sequence Detail	408	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1603 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR026823	Complement Clr-like EGF domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
Protein Ontology	PR:000005096	collagen and calcium-binding EGF domain-containing protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194396 Hagerling R, et al., A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013 Feb 12;32(5):629-44
All references(28)

Other accession IDs

MGI:1918322