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Tbck Gene Detail
Summary
  • Symbol
    Tbck
  • Name
    TBC1 domain containing kinase
  • Synonyms
    1700120J03Rik, A630047E20Rik, C030007I09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445052
    NCBI Gene: 271981
Location & Maps
more
  • Sequence Map
    Chr3:132684144-132841688 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      157545 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 61.49 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TBCK, TBC1 domain containing kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBCK, TBC1 domain containing kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC302, IHPRF3, TBCKL
  • Links
    NCBI Gene ID: 93627
    neXtProt AC: NX_Q8TEA7

  • Chr Location
    4q24; chr4:106044317-106316704 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13221
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TBCK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Tbck
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055158 VEGA Gene Model | MGI Sequence Detail 157545 C57BL/6J ±  kb
transcript OTTMUST00000136595 VEGA | MGI Sequence Detail 6578 Not Applicable  
polypeptide OTTMUSP00000072070 VEGA | MGI Sequence Detail 893 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    888 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029782 TBC domain-containing protein kinase-like protein
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR000195 Rab-GTPase-TBC domain
    IPR001763 Rhodanese-like domain
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:1921563, MGI:1924592
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory