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Exoc1 Gene Detail
Summary
  • Symbol
    Exoc1
  • Name
    exocyst complex component 1
  • Synonyms
    2810407P21Rik, A730011E05Rik, SEC3, Sec3l1, Sec3p
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445020
    NCBI Gene: 69940
  • Gene Overview
    MyGene.info: EXOC1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76529311-76570294 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.28 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445020
protein coding gene Chr5:76529307-76570298 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029645
protein coding gene Chr5:76719577-76762540 (+)
A/J MGP_AJ_G0029613
protein coding gene Chr5:73796573-73838290 (+)
AKR/J MGP_AKRJ_G0029561
protein coding gene Chr5:76197822-76238727 (+)
BALB/cJ MGP_BALBcJ_G0029622
protein coding gene Chr5:74527864-74568908 (+)
C3H/HeJ MGP_C3HHeJ_G0029345
protein coding gene Chr5:76569025-76613815 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030076
protein coding gene Chr5:79783793-79824697 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027317
protein coding gene Chr5:69424464-69465511 (+)
CAST/EiJ MGP_CASTEiJ_G0028753
protein coding gene Chr5:75773736-75814436 (+)
CBA/J MGP_CBAJ_G0029314
protein coding gene Chr5:82409998-82450848 (+)
DBA/2J MGP_DBA2J_G0029459
protein coding gene Chr5:73854563-73896621 (+)
FVB/NJ MGP_FVBNJ_G0029420
protein coding gene Chr5:73053520-73095907 (+)
LP/J MGP_LPJ_G0029546
protein coding gene Chr5:77156403-77197312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029448
protein coding gene Chr5:85575785-85618385 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030109
protein coding gene Chr5:75750483-75792255 (+)
PWK/PhJ MGP_PWKPhJ_G0028476
protein coding gene Chr5:72871673-72912809 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028311
protein coding gene Chr5:75105883-75146614 (+)
WSB/EiJ MGP_WSBEiJ_G0028833
protein coding gene Chr5:76071615-76113192 (+)



Homology
more
  • Human Ortholog
    EXOC1, exocyst complex component 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EXOC1, exocyst complex component 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM-102, SEC3, SEC3L1, SEC3P
  • Links
    NCBI Gene ID: 55763
    neXtProt AC: NX_Q9NV70
    UniProt: Q9NV70

  • Chr Location
    4q12; chr4:55853616-55905078 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036435 Ensembl Gene Model | MGI Sequence Detail 40984 C57BL/6J ±  kb
transcript ENSMUST00000113493 Ensembl | MGI Sequence Detail 3371 Not Applicable  
polypeptide ENSMUSP00000109121 Ensembl | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR019160 Exocyst complex component Sec3, C-terminal
    IPR028258 Exocyst complex component Sec3, PIP2-binding N-terminal domain
Molecular
Reagents
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  • All nucleic 96
    cDNA 96

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917190
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:250161 Lee AJ, et al., Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Sci Rep. 2016 Aug 11;6:31137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory