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Pik3c3 Gene Detail
Summary
  • Symbol
    Pik3c3
  • Name
    phosphatidylinositol 3-kinase catalytic subunit type 3
  • Synonyms
    5330434F23Rik, Vps34
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445019
    NCBI Gene: 225326
  • Gene Overview
    MyGene.info: PIK3C3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:30272747-30348126 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75380 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.41 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hVps34, Vps34, VPS34
  • Links
    NCBI Gene ID: 5289
    neXtProt AC: NX_Q8NEB9
    UniProt: Q8NEB9

  • Chr Location
    18q12.3; chr18:41955196-42084606 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive Tcell homeostasis and mitophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021153 VEGA Gene Model | MGI Sequence Detail 75380 C57BL/6J ±  kb
    transcript OTTMUST00000050105 VEGA | MGI Sequence Detail 3257 Not Applicable  
    polypeptide OTTMUSP00000023341 VEGA | MGI Sequence Detail 887 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      581 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012718 phosphatidylinositol 3-kinase catalytic subunit type 3
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR002420 Phosphatidylinositol 3-kinase, C2 domain
      IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR011009 Protein kinase-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 102
      cDNA 102

      Microarray probesets 3
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:33394 Virbasius JV, et al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13304-7
    • Latest
      J:262725 Khambu B, et al., HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. 2018 Jun 1;128(6):2419-2435

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory