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Pik3c3 Gene Detail
Summary
  • Symbol
    Pik3c3
  • Name
    phosphoinositide-3-kinase, class 3
  • Synonyms
    5330434F23Rik, Vps34
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445019
    NCBI Gene: 225326
  • Gene Overview
    MyGene.info: PIK3C3
Location & Maps
more
  • Sequence Map
    Chr18:30272747-30348126 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      75380 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.41 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hVps34, Vps34, VPS34
  • Links
    NCBI Gene ID: 5289
    neXtProt AC: NX_Q8NEB9

  • Chr Location
    18q12.3; chr18:41955199-42084606 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 5 alleles in 7 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive Tcell homeostasis and mitophagy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021153 VEGA Gene Model | MGI Sequence Detail 75380 C57BL/6J ±  kb
transcript OTTMUST00000050105 VEGA | MGI Sequence Detail 3257 Not Applicable  
polypeptide OTTMUSP00000023341 VEGA | MGI Sequence Detail 887 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    581 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012718 phosphatidylinositol 3-kinase catalytic subunit type 3
  • EC
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000008 C2 domain
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR002420 Phosphatidylinositol 3-kinase, C2 domain
    IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
    IPR015433 Phosphatidylinositol Kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR011009 Protein kinase-like domain
Molecular
Reagents
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  • All nucleic 101
    cDNA 101

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 12
    Phenotypes 14
  • Earliest
    J:33394 Virbasius JV, et al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13304-7
  • Latest
    J:219972 Vicinanza M, et al., PI(5)P regulates autophagosome biogenesis. Mol Cell. 2015 Jan 22;57(2):219-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory