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Pik3c3
Gene Detail
 Symbol
Name
ID
Pik3c3
phosphoinositide-3-kinase, class 3
MGI:2445019
Synonyms 5330434F23Rik, Vps34
Feature Type protein coding gene
Genetic Map
Chromosome 18
17.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:30272747-30348126 bp, + strand
From VEGA annotation of GRCm38

  75380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase, Vps34 type
Gene Tree: Pik3c3

Human
homologs
Human Homolog PIK3C3, phosphatidylinositol 3-kinase, catalytic subunit type 3
NCBI Gene ID 5289
neXtProt AC  NX_Q8NEB9
Human Synonyms  hVps34, VPS34
Human Chr (Location)  18q12.3; chr18:41955234-42081484 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive T cell homeostasis and mitophagy.
 
Phenotype Images(6)
Interactions
Pik3c3 interacts with 285 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component endosome, late endosome, ...
Function 1-phosphatidylinositol-3-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (252)    Tissues (111)    Images (30)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 252
cDNA source data(101)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(101) cDNA(101)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021153 (Evidence)
Ensembl Gene ModelENSMUSG00000033628 (Evidence)
Entrez Gene225326 (Evidence)
UniGene194127
DFCITC1577402, TC1596455, TC1628848
DoTSDT.101202280, DT.101736495, DT.486006, DT.87059827
NIA Mouse Gene IndexU137145
EC2.7.1.137
Consensus CDS ProjectCCDS37752.1
International Mouse Knockout Project StatusPik3c3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021153 VEGA Gene Model | MGI Sequence Detail 75380 C57BL/6J ±  kb
transcript OTTMUST00000050105 VEGA | MGI Sequence Detail 3257 Not Applicable 
polypeptide OTTMUSP00000023341 VEGA | MGI Sequence Detail 887 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(577 from dbSNP Build 137)    SNPs within 2kb including multiple locations(607)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR002420 Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000012718 phosphatidylinositol 3-kinase catalytic subunit type 3
References (Earliest) J:33394 Virbasius JV, et al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13304-7
(Latest) J:210957 Reifler A, et al., Conditional knockout of pik3c3 causes a murine muscular dystrophy. Am J Pathol. 2014 Jun;184(6):1819-30
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory