About   Help   FAQ
Pik3c3 Gene Detail
Summary
  • Symbol
    Pik3c3
  • Name
    phosphatidylinositol 3-kinase catalytic subunit type 3
  • Synonyms
    5330434F23Rik, Vps34
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445019
    NCBI Gene: 225326
  • Gene Overview
    MyGene.info: PIK3C3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:30272747-30348126 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 17.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    581 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445019
protein coding gene Chr18:30272094-30348126 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024210
protein coding gene Chr18:28310329-28395486 (+)
A/J MGP_AJ_G0024175
protein coding gene Chr18:27390216-27466210 (+)
AKR/J MGP_AKRJ_G0024144
protein coding gene Chr18:28138996-28215755 (+)
BALB/cJ MGP_BALBcJ_G0024175
protein coding gene Chr18:27469823-27550057 (+)
C3H/HeJ MGP_C3HHeJ_G0023943
protein coding gene Chr18:28159184-28238270 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024617
protein coding gene Chr18:29324105-29405114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022059
protein coding gene Chr18:27664029-27742066 (+)
CAST/EiJ MGP_CASTEiJ_G0023417
protein coding gene Chr18:28011774-28110009 (+)
CBA/J MGP_CBAJ_G0023911
protein coding gene Chr18:30239889-30317437 (+)
DBA/2J MGP_DBA2J_G0024043
protein coding gene Chr18:27065705-27141537 (+)
FVB/NJ MGP_FVBNJ_G0024009
protein coding gene Chr18:26788733-26864274 (+)
LP/J MGP_LPJ_G0024124
protein coding gene Chr18:28423285-28498837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024037
protein coding gene Chr18:31531063-31621280 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024665
protein coding gene Chr18:28001552-28080825 (+)
PWK/PhJ MGP_PWKPhJ_G0023161
protein coding gene Chr18:27203988-27281610 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022970
protein coding gene Chr18:28226337-28323576 (+)
WSB/EiJ MGP_WSBEiJ_G0023481
protein coding gene Chr18:27884784-27962412 (+)



Homology
more
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3C3, phosphatidylinositol 3-kinase catalytic subunit type 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hVps34, Vps34, VPS34
  • Links
    NCBI Gene ID: 5289
    neXtProt AC: NX_Q8NEB9
    UniProt: Q8NEB9

  • Chr Location
    18q12.3; chr18:41955196-42084606 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 6 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive Tcell homeostasis and mitophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033628 Ensembl Gene Model | MGI Sequence Detail 75380 C57BL/6J ±  kb
    transcript ENSMUST00000115812 Ensembl | MGI Sequence Detail 3257 Not Applicable  
    polypeptide ENSMUSP00000111479 Ensembl | MGI Sequence Detail 887 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012718 phosphatidylinositol 3-kinase catalytic subunit type 3
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR002420 Phosphatidylinositol 3-kinase, C2 domain
      IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR011009 Protein kinase-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 102

      Microarray probesets 3
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:33394 Virbasius JV, et al., Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem. 1996 Jun 7;271(23):13304-7
    • Latest
      J:262725 Khambu B, et al., HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. 2018 Jun 1;128(6):2419-2435

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory