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Arhgap1 Gene Detail
Summary
  • Symbol
    Arhgap1
  • Name
    Rho GTPase activating protein 1
  • Synonyms
    B230365D05Rik, Cdc42GAP, p50rhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445003
    NCBI Gene: 228359
  • Gene Overview
    MyGene.info: ARHGAP1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91649875-91672325 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445003
protein coding gene Chr2:91649860-91672326 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026154
protein coding gene Chr2:92999444-93028174 (+)
A/J MGP_AJ_G0026115
protein coding gene Chr2:89269477-89292028 (+)
AKR/J MGP_AKRJ_G0026096
protein coding gene Chr2:91737909-91760439 (+)
BALB/cJ MGP_BALBcJ_G0026124
protein coding gene Chr2:89453445-89475986 (+)
C3H/HeJ MGP_C3HHeJ_G0025875
protein coding gene Chr2:92020424-92043591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026575
protein coding gene Chr2:96252167-96276724 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023966
protein coding gene Chr2:85766991-85790017 (+)
CAST/EiJ MGP_CASTEiJ_G0025340
protein coding gene Chr2:92569537-92592911 (+)
CBA/J MGP_CBAJ_G0025853
protein coding gene Chr2:99556192-99578786 (+)
DBA/2J MGP_DBA2J_G0025989
protein coding gene Chr2:88872143-88894595 (+)
FVB/NJ MGP_FVBNJ_G0025952
protein coding gene Chr2:87970914-87993362 (+)
LP/J MGP_LPJ_G0026093
protein coding gene Chr2:93216765-93239550 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025978
protein coding gene Chr2:102575210-102599089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026629
protein coding gene Chr2:91811391-91835265 (+)
PWK/PhJ MGP_PWKPhJ_G0025075
protein coding gene Chr2:88604394-88628087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024876
protein coding gene Chr2:91392407-91413678 (+)
WSB/EiJ MGP_WSBEiJ_G0025407
protein coding gene Chr2:92411433-92434322 (+)



Homology
more
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1
  • Links
    NCBI Gene ID: 392
    neXtProt AC: NX_Q07960
    UniProt: Q07960

  • Chr Location
    11p11.2; chr11:46677075-46700665 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228359 NCBI Gene Model | MGI Sequence Detail 22451 C57BL/6J ±  kb
transcript NM_146124 RefSeq | MGI Sequence Detail 3113 C57BL/6  
polypeptide Q5FWK3 UniProt | EBI | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001251 CRAL-TRIO lipid binding domain
    IPR036865 CRAL-TRIO lipid binding domain superfamily
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 141
    cDNA 141

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139453
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory