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Arhgap1
Gene Detail
Symbol

Name
ID
Arhgap1
Rho GTPase activating protein 1
MGI:2445003
Synonyms
B230365D05Rik, Cdc42GAP, p50rhoGAP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:91649860-91672326 bp, + strand
From VEGA annotation of GRCm38

  22467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20909  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGAP1
Protein SuperFamily: Rho GTPase-activating protein, p50 rhoGAP type
Gene Tree: Arhgap1

Human
homologs
ARHGAP1, Rho GTPase activating protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 392
neXtProt AC: NX_Q07960

Human Synonyms: CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1

Human Chr (Location): 11p11.2; chr11:46677075-46700665 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(27) Targeted(3)
Genomic Mutations involving Arhgap1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.
 
Phenotype Images(2)
Interactions
Arhgap1 interacts with 247 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process positive regulation of GTPase activity, regulation of GTPase activity, ...
Component cell leading edge, cytoplasm, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGAP1 ; Xenbase arhgap1    NEW 
Molecular
reagents
All nucleic(140) cDNA(140)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014300 (Evidence)
Ensembl Gene Model ENSMUSG00000027247 (Evidence)
Entrez Gene 228359 (Evidence)
UniGene 22413
DFCI TC1575098, TC1649452, TC1709974, TC1708646, TC1655458, TC1742875
NIA Mouse Gene Index U355379, U355607, U002127
Consensus CDS Project CCDS16437.1, CCDS50641.1
International Mouse Phenotyping Consortium Status Arhgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014300 VEGA Gene Model | MGI Sequence Detail 22467 C57BL/6J ±  kb
transcript OTTMUST00000033705 VEGA | MGI Sequence Detail 2883 Not Applicable 
polypeptide OTTMUSP00000015106 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(25) UniProt(5)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004218 rho GTPase-activating protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193430 Rossi L, et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17
All references(42)
Other
accession IDs
MGI:2139453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory