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Arhgap1 Gene Detail
Summary
  • Symbol
    Arhgap1
  • Name
    Rho GTPase activating protein 1
  • Synonyms
    B230365D05Rik, Cdc42GAP, p50rhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445003
    NCBI Gene: 228359
  • Gene Overview
    MyGene.info: ARHGAP1
Location & Maps
more
  • Sequence Map
    Chr2:91649860-91672326 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22467 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP1, Rho GTPase activating protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1
  • Links
    NCBI Gene ID: 392
    neXtProt AC: NX_Q07960

  • Chr Location
    11p11.2; chr11:46677075-46700665 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Arhgap1
  • Incidental Mutations
Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014300 VEGA Gene Model | MGI Sequence Detail 22467 C57BL/6J ±  kb
transcript OTTMUST00000033705 VEGA | MGI Sequence Detail 2883 Not Applicable  
polypeptide OTTMUSP00000015106 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004218 rho GTPase-activating protein 1
  • InterPro Domains
    IPR001251 CRAL-TRIO lipid binding domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
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  • All nucleic 140
    cDNA 140

    Microarray probesets 4
Other
Accession IDs
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MGI:2139453
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:193430 Rossi L, et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory