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Arhgap1
Gene Detail
Symbol

Name
ID
Arhgap1
Rho GTPase activating protein 1
MGI:2445003
Synonyms
B230365D05Rik, Cdc42GAP, p50rhoGAP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:91649860-91672326 bp, + strand
From VEGA annotation of GRCm38

  22467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20909  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Rho GTPase-activating protein, p50 rhoGAP type
Gene Tree: Arhgap1

Human
homologs
Human Homolog ARHGAP1, Rho GTPase activating protein 1
NCBI Gene ID 392
neXtProt AC  NX_Q07960
Human Synonyms  CDC42GAP, p50rhoGAP, RHOGAP, RHOGAP1
Human Chr (Location)  11p11.2; chr11:46677075-46700665 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(27) Targeted(3)
Genomic Mutations involving Arhgap1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display incomplete penetrance of postnatal lethality, increased apoptosis, and growth retardation.
 
Phenotype Images(2)
Interactions
Arhgap1 interacts with 247 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process positive regulation of Rac GTPase activity, positive regulation of Rho GTPase activity, ...
Component cell leading edge, cytoplasm, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(140) cDNA(140)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014300 (Evidence)
Ensembl Gene ModelENSMUSG00000027247 (Evidence)
Entrez Gene228359 (Evidence)
UniGene22413
DFCITC1575098, TC1649452, TC1655458, TC1708646, TC1709974, TC1742875
NIA Mouse Gene IndexU002127, U355379, U355607
Consensus CDS ProjectCCDS16437.1, CCDS50641.1
International Mouse Knockout Project StatusArhgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014300 VEGA Gene Model | MGI Sequence Detail 22467 C57BL/6J ±  kb
transcript OTTMUST00000033705 VEGA | MGI Sequence Detail 2883 Not Applicable 
polypeptide OTTMUSP00000015106 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(23) UniProt(5)
Polymorphisms
SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001251 CRAL-TRIO domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004218 rho GTPase-activating protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193430 Rossi L, et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17
All references(41)
Other
accession IDs
MGI:2139453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory