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Rad54b Gene Detail
Summary
  • Symbol
    Rad54b
  • Name
    RAD54 homolog B (S. cerevisiae)
  • Synonyms
    E130016E03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3605986
    NCBI Gene: 623474
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:11558930-11615806 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 5.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3605986
 protein coding gene Chr4:11558922-11615806 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028054
 protein coding gene Chr4:8228996-8291427 (+)
A/J MGP_AJ_G0028011
 protein coding gene Chr4:8097962-8157228 (+)
AKR/J MGP_AKRJ_G0027977
 protein coding gene Chr4:8185656-8243453 (+)
BALB/cJ MGP_BALBcJ_G0028023
 protein coding gene Chr4:8024766-8082182 (+)
C3H/HeJ MGP_C3HHeJ_G0027753
 protein coding gene Chr4:8359771-8419341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028466
 protein coding gene Chr4:8640365-8700810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025810
 protein coding gene Chr4:7607827-7677777 (+)
CAST/EiJ MGP_CASTEiJ_G0027207
 protein coding gene Chr4:8172457-8233050 (+)
CBA/J MGP_CBAJ_G0027728
 protein coding gene Chr4:8879675-8947439 (+)
DBA/2J MGP_DBA2J_G0027869
 protein coding gene Chr4:7968818-8026088 (+)
FVB/NJ MGP_FVBNJ_G0027835
 protein coding gene Chr4:7798912-7855751 (+)
LP/J MGP_LPJ_G0027979
 protein coding gene Chr4:8311729-8371302 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027868
 protein coding gene Chr4:9059474-9129247 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028525
 protein coding gene Chr4:8192709-8250435 (+)
PWK/PhJ MGP_PWKPhJ_G0026928
 protein coding gene Chr4:7983452-8041863 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026758
 protein coding gene Chr4:8102582-8161509 (+)
WSB/EiJ MGP_WSBEiJ_G0027286
 protein coding gene Chr4:8253074-8315861 (+)



Homology
more
  • Human Ortholog
    RAD54B, RAD54 homolog B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD54B, RAD54 homolog B
  • Synonyms
    RDH54
  • Links
    NCBI Gene ID: 25788
    neXtProt AC: NX_O95073, NX_Q9Y620
    UniProt: Q9Y620

  • Chr Location
    8q22.1; chr8:94371960-94475115 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RAD54B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have an increased sensitivity to ionizing radiation and other agents of DNA damage but outherwise have a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    92
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 623474 NCBI Gene Model | MGI Sequence Detail 56877 C57BL/6J ±  kb
transcript NM_001256145 RefSeq | MGI Sequence Detail 4661 C57BL/6  
polypeptide Q6PFE3 UniProt | EBI | MGI Sequence Detail 886 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2444973
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:330465 Russo A, et al., Rad54/Rad54B deficiency is associated to increased chromosome breakage in mouse spermatocytes. Mutagenesis. 2018 Oct 11;33(4):323-332
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory