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Tecrl Gene Detail
Summary
  • Symbol
    Tecrl
  • Name
    trans-2,3-enoyl-CoA reductase-like
  • Synonyms
    D330017N19Rik, Srd5a2l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444966
    NCBI Gene: 243078
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:83425992-83503042 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444966
 protein coding gene Chr5:83425969-83503042 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029661
 protein coding gene Chr5:83956708-84027121 (-)
A/J MGP_AJ_G0029629
 protein coding gene Chr5:80537326-80617064 (-)
AKR/J MGP_AKRJ_G0029577
 protein coding gene Chr5:83233331-83313410 (-)
BALB/cJ MGP_BALBcJ_G0029638
 protein coding gene Chr5:81399896-81485524 (-)
C3H/HeJ MGP_C3HHeJ_G0029361
 protein coding gene Chr5:83694229-83773104 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030092
 protein coding gene Chr5:87339019-87423191 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027334
 protein coding gene Chr5:76568449-76644687 (-)
CAST/EiJ MGP_CASTEiJ_G0028769
 protein coding gene Chr5:82939112-83022014 (-)
CBA/J MGP_CBAJ_G0029330
 protein coding gene Chr5:90156984-90258405 (-)
DBA/2J MGP_DBA2J_G0029475
 protein coding gene Chr5:80664602-80743841 (-)
FVB/NJ MGP_FVBNJ_G0029436
 protein coding gene Chr5:79734172-79814542 (-)
LP/J MGP_LPJ_G0029562
 protein coding gene Chr5:84355922-84446200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029464
 protein coding gene Chr5:94378170-94479519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030125
 protein coding gene Chr5:82793475-82884480 (-)
PWK/PhJ MGP_PWKPhJ_G0028493
 protein coding gene Chr5:79698990-79780915 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028327
 protein coding gene Chr5:82149051-82230992 (-)
WSB/EiJ MGP_WSBEiJ_G0028850
 protein coding gene Chr5:83149126-83232237 (-)



Homology
more
  • Human Ortholog
    TECRL, trans-2,3-enoyl-CoA reductase like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TECRL, trans-2,3-enoyl-CoA reductase like
  • Synonyms
    CPVT3, GPSN2L, SRD5A2L2, TERL
  • Links
    NCBI Gene ID: 253017
    UniProt: Q5HYJ1

  • Chr Location
    4q13.1; chr4:64275257-64409468 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TECRL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show cardiac dysfunction, impaired mitochondrial respiration in cardiomyocytes, characterized by reduced ATP production and increased reactive oxygen species production, and mitochondrial ultrastructure changes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049537 Ensembl Gene Model | MGI Sequence Detail 77051 C57BL/6J ±  kb
    transcript ENSMUST00000053543 Ensembl | MGI Sequence Detail 2350 Not Applicable  
    polypeptide ENSMUSP00000062122 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015609 steroid 5-alpha-reductase 2-like 2 protein
      (term hierarchy)
    • EC
      1.3.1.-
    • InterPro Domains
      IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
      IPR039357 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase
      IPR049127 TECR-like, N-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:361048 Geng S, et al., Deletion of TECRL promotes skeletal muscle repair by up-regulating EGR2. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2317495121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    03/25/2025
    MGI 6.24     		The Jackson Laboratory