Tecrl MGI Mouse Gene Detail - MGI:2444966 - trans-2,3-enoyl-CoA reductase-like

Symbol

Tecrl
Name

trans-2,3-enoyl-CoA reductase-like
Synonyms

D330017N19Rik, Srd5a2l2

Feature Type

protein coding gene
IDs

MGI:2444966
NCBI Gene: 243078
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:83425992-83503042 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.00 cM
Mapping Data

1 experiment

SNPs within 2kb

492 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444966	protein coding gene	Chr5:83425969-83503042 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029661	protein coding gene	Chr5:83956708-84027121 (-)
A/J	MGP_AJ_G0029629	protein coding gene	Chr5:80537326-80617064 (-)
AKR/J	MGP_AKRJ_G0029577	protein coding gene	Chr5:83233331-83313410 (-)
BALB/cJ	MGP_BALBcJ_G0029638	protein coding gene	Chr5:81399896-81485524 (-)
C3H/HeJ	MGP_C3HHeJ_G0029361	protein coding gene	Chr5:83694229-83773104 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030092	protein coding gene	Chr5:87339019-87423191 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027334	protein coding gene	Chr5:76568449-76644687 (-)
CAST/EiJ	MGP_CASTEiJ_G0028769	protein coding gene	Chr5:82939112-83022014 (-)
CBA/J	MGP_CBAJ_G0029330	protein coding gene	Chr5:90156984-90258405 (-)
DBA/2J	MGP_DBA2J_G0029475	protein coding gene	Chr5:80664602-80743841 (-)
FVB/NJ	MGP_FVBNJ_G0029436	protein coding gene	Chr5:79734172-79814542 (-)
LP/J	MGP_LPJ_G0029562	protein coding gene	Chr5:84355922-84446200 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029464	protein coding gene	Chr5:94378170-94479519 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030125	protein coding gene	Chr5:82793475-82884480 (-)
PWK/PhJ	MGP_PWKPhJ_G0028493	protein coding gene	Chr5:79698990-79780915 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028327	protein coding gene	Chr5:82149051-82230992 (-)
WSB/EiJ	MGP_WSBEiJ_G0028850	protein coding gene	Chr5:83149126-83232237 (-)

Human Ortholog

TECRL, trans-2,3-enoyl-CoA reductase like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TECRL, trans-2,3-enoyl-CoA reductase like
Synonyms

CPVT3, GPSN2L, SRD5A2L2, TERL
Links

HGNC:27365

NCBI Gene ID: 253017

neXtProt AC: NX_Q5HYJ1

UniProt: Q5HYJ1
Chr Location

4q13.1; chr4:64276298-64409509 (-) GRCh38.p7

Alliance of Genome Resources

Tecrl stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TECRL
Gene Tree

Tecrl

Diseases

1 with human TECRL associations

				Human Disease	Mouse Models
				catecholaminergic polymorphic ventricular tachycardia 3 IDs catecholaminergic polymorphic ventricular tachycardia 3 DOID:0060677 ICD10CM:I47.2 OMIM:614021

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Tecrl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TECRL

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Tecrl interacts with 179 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS19375.1

Ensembl

ENSMUSG00000049537 (Evidence)
NCBI Gene

243078

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049537	Ensembl Gene Model \| MGI Sequence Detail	77051	C57BL/6J	± kb
transcript	ENSMUST00000053543	Ensembl \| MGI Sequence Detail	2350	Not Applicable
polypeptide	ENSMUSP00000062122	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015609 steroid 5-alpha-reductase 2-like 2 protein

(term hierarchy)
EC

1.3.1.-
InterPro Domains

IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal

IPR039357 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase

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All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 32

Gene Ontology 4

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:325991 Hou C, et al., TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes. Commun Biol. 2022 May 16;5(1):470

TSS for Tecrl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51500	Chr5:83502967-83502974 (-)	71 bp
Tssr51499	Chr5:83502940-83502960 (-)	92 bp
Tssr51498	Chr5:83502919-83502939 (-)	113 bp
Tssr51497	Chr5:83502826-83502907 (-)	175 bp
Tssr51496	Chr5:83502793-83502820 (-)	235 bp
Tssr51495	Chr5:83502771-83502791 (-)	261 bp
Tssr51494	Chr5:83502735-83502758 (-)	295 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/22/2022 MGI 6.21