About   Help   FAQ
Kmt2c Gene Detail
Summary
  • Symbol
    Kmt2c
  • Name
    lysine (K)-specific methyltransferase 2C
  • Synonyms
    E330008K23Rik, HALR, mKIAA1506, Mll3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444959
    NCBI Gene: 231051
  • Gene Overview
    MyGene.info: KMT2C
Location & Maps
more
  • Sequence Map
    Chr5:25271798-25498783 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      226986 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 12.35 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KMT2C, lysine methyltransferase 2C
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KMT2C, lysine methyltransferase 2C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HALR, MLL3
  • Links
    NCBI Gene ID: 58508
    neXtProt AC: NX_Q8NEZ4

  • Chr Location
    7q36.1; chr7:152134925-152436638 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Chemically induced (other)
    2
  • Gene trapped
    34
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    5 involving Kmt2c
  • Incidental Mutations
Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037000 VEGA Gene Model | MGI Sequence Detail 226986 C57BL/6J ±  kb
transcript OTTMUST00000095145 VEGA | MGI Sequence Detail 14967 Not Applicable  
polypeptide OTTMUSP00000053056 VEGA | MGI Sequence Detail 4904 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    941 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 25
    Primer pair 2

    Microarray probesets 7
References
more
  • Summaries
    All 56
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:229465 Starnes LM, et al., A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016 Jan 15;30(2):149-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory