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Kmt2c
Gene Detail
Symbol

Name
ID
Kmt2c
lysine (K)-specific methyltransferase 2C
MGI:2444959
Synonyms
E330008K23Rik, HALR, mKIAA1506, Mll3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
12.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:25271798-25498786 bp, - strand
From VEGA annotation of GRCm38

  226989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:46480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KMT2C
Protein SuperFamily: acute lymphoblastic leukemia protein, ALR type
Gene Tree: Kmt2c

Human
homologs
KMT2C, lysine (K)-specific methyltransferase 2C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 58508
neXtProt AC: NX_Q8NEZ4

Human Synonyms: HALR, MLL3

Human Chr (Location): 7q36.1; chr7:152134925-152436638 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Radiation induced(1) Targeted(3)
Genomic Mutations involving Kmt2c (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts.
 
Phenotype Images(1)
Interactions
Kmt2c interacts with 389 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chromatin modification, histone H3-K4 methylation, ...
Component histone methyltransferase complex, nucleus
Function DNA binding, histone-lysine N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (218)    Tissues (195)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 198
RT-PCR 20
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kmt2c ; ZFIN kmt2ca, kmt2cb    NEW 
Molecular
reagents
All nucleic(27) cDNA(25) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000037000 (Evidence)
Ensembl Gene Model ENSMUSG00000038056 (Evidence)
Entrez Gene 231051 (Evidence)
DFCI TC1731990, TC1597950, TC1622597, TC1578995, TC1598877
DoTS DT.91299272, DT.94254590, DT.40143191, DT.55276988, DT.101736382
NIA Mouse Gene Index U372479, U026010
EC 2.1.1.43
Consensus CDS Project CCDS39033.1
International Mouse Phenotyping Consortium Status Kmt2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037000 VEGA Gene Model | MGI Sequence Detail 226989 C57BL/6J ±  kb
transcript OTTMUST00000095145 VEGA | MGI Sequence Detail 14967 Not Applicable 
polypeptide OTTMUSP00000053056 VEGA | MGI Sequence Detail 4904 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(42) UniProt(11)
Polymorphisms
SNPs within 2kb(949 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR003889 FY-rich, C-terminal
InterPro IPR003888 FY-rich, N-terminal
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR000637 HMG-I/HMG-Y, DNA-binding, conserved site
InterPro IPR003616 Post-SET domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR001214 SET domain
InterPro IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000010447 histone-lysine N-methyltransferase MLL3
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:215367 Shao GB, et al., Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development. In Vitro Cell Dev Biol Anim. 2014 Aug;50(7):603-13
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory