About   Help   FAQ
Tmco3 Gene Detail
Summary
  • Symbol
    Tmco3
  • Name
    transmembrane and coiled-coil domains 3
  • Synonyms
    B230339H12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444946
    NCBI Gene: 234076
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13338190-13372924 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444946
 protein coding gene Chr8:13333214-13372924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033377
 protein coding gene Chr8:10627615-10666126 (+)
A/J MGP_AJ_G0033357
 protein coding gene Chr8:10241087-10280925 (+)
AKR/J MGP_AKRJ_G0033288
 protein coding gene Chr8:10523225-10559929 (+)
BALB/cJ MGP_BALBcJ_G0033358
 protein coding gene Chr8:10374909-10411449 (+)
C3H/HeJ MGP_C3HHeJ_G0033071
 protein coding gene Chr8:10730793-10772737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033870
 protein coding gene Chr8:11000999-11035460 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030839
 protein coding gene Chr8:9746343-9781303 (+)
CAST/EiJ MGP_CASTEiJ_G0032393
 protein coding gene Chr8:10490999-10533056 (+)
CBA/J MGP_CBAJ_G0033044
 protein coding gene Chr8:11458645-11502883 (+)
DBA/2J MGP_DBA2J_G0033197
 protein coding gene Chr8:10190369-10227356 (+)
FVB/NJ MGP_FVBNJ_G0033146
 protein coding gene Chr8:10207354-10242666 (+)
LP/J MGP_LPJ_G0033291
 protein coding gene Chr8:10534118-10574706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033180
 protein coding gene Chr8:11689963-11727196 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033887
 protein coding gene Chr8:10580171-10621222 (+)
PWK/PhJ MGP_PWKPhJ_G0032106
 protein coding gene Chr8:10243002-10280029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031948
 protein coding gene Chr8:10472296-10508804 (+)
WSB/EiJ MGP_WSBEiJ_G0032509
 protein coding gene Chr8:10616834-10654604 (+)



Homology
more
  • Human Ortholog
    TMCO3, transmembrane and coiled-coil domains 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMCO3, transmembrane and coiled-coil domains 3
  • Synonyms
    C13orf11, SLC9D1
  • Links
    NCBI Gene ID: 55002
    UniProt: Q6UWJ1

  • Chr Location
    13q34; chr13:113491021-113554590 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    31
  • cDNA Data
    47
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038497 Ensembl Gene Model | MGI Sequence Detail 34735 C57BL/6J ±  kb
    transcript ENSMUST00000045229 Ensembl | MGI Sequence Detail 4335 Not Applicable  
    polypeptide ENSMUSP00000040347 Ensembl | MGI Sequence Detail 678 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016400 transmembrane and coiled-coil domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR006153 Cation/H+ exchanger
      IPR045158 K(+) efflux antiporter 4/5/6-like
      IPR038770 Sodium/solute symporter superfamily
    • GlyGen
      Q8BH01 4 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142882
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory