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Pla2g3 Gene Detail
Summary
  • Symbol
    Pla2g3
  • Name
    phospholipase A2, group III
  • Synonyms
    9130003P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444945
    NCBI Gene: 237625
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3488284-3499350 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444945
protein coding gene Chr11:3488092-3499350 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017958
protein coding gene Chr11:360776-371858 (+)
A/J MGP_AJ_G0017931
protein coding gene Chr11:405900-416983 (+)
AKR/J MGP_AKRJ_G0017895
protein coding gene Chr11:423812-434888 (+)
BALB/cJ MGP_BALBcJ_G0017899
protein coding gene Chr11:377680-388736 (+)
C3H/HeJ MGP_C3HHeJ_G0017712
protein coding gene Chr11:358712-369771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018352
protein coding gene Chr11:431797-442859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016011
protein coding gene Chr11:315204-326146 (+)
CAST/EiJ MGP_CASTEiJ_G0017274
protein coding gene Chr11:312814-324156 (+)
CBA/J MGP_CBAJ_G0017687
protein coding gene Chr11:596574-610662 (+)
DBA/2J MGP_DBA2J_G0017798
protein coding gene Chr11:324527-335588 (+)
FVB/NJ MGP_FVBNJ_G0017789
protein coding gene Chr11:355075-366146 (+)
LP/J MGP_LPJ_G0017868
protein coding gene Chr11:458296-469168 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017815
protein coding gene Chr11:343635-354741 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018391
protein coding gene Chr11:434342-447230 (+)
PWK/PhJ MGP_PWKPhJ_G0017054
protein coding gene Chr11:298861-310079 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016850
protein coding gene Chr11:388529-399591 (+)
WSB/EiJ MGP_WSBEiJ_G0017328
protein coding gene Chr11:311674-322746 (+)



Homology
more
  • Human Ortholog
    PLA2G3, phospholipase A2 group III
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLA2G3, phospholipase A2 group III
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GIII-SPLA2, sPLA2-III, SPLA2III
  • Links
    NCBI Gene ID: 50487
    neXtProt AC: NX_Q9NZ20
    UniProt: Q9NZ20

  • Chr Location
    22q12.2; chr22:31134807-31140607 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice have reduced male fertility with smaller litter size and decreased susceptibility to IgE antigen-induced passive systemic and cutaneous anaphylaxis due to impaired mast cell maturation, degranulation and histamine release.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034579 Ensembl Gene Model | MGI Sequence Detail 11067 C57BL/6J ±  kb
    transcript ENSMUST00000064265 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000068699 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR016090 Phospholipase A2 domain
      IPR036444 Phospholipase A2 domain superfamily
      IPR033113 Phospholipase A2, histidine active site
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:256369 Murase R, et al., Group III phospholipase A2 promotes colitis and colorectal cancer. Sci Rep. 2017 Sep 25;7(1):12261

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory