Pla2g3 MGI Mouse Gene Detail - MGI:2444945 - phospholipase A2, group III

Symbol

Pla2g3
Name

phospholipase A2, group III
Synonyms

9130003P18Rik

Feature Type

protein coding gene
IDs

MGI:2444945
NCBI Gene: 237625
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:3438284-3449350 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.45 cM
Mapping Data

1 experiment

SNPs within 2kb

26 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444945	protein coding gene	Chr11:3438158-3449350 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017958	protein coding gene	Chr11:360776-371858 (+)
A/J	MGP_AJ_G0017931	protein coding gene	Chr11:405900-416983 (+)
AKR/J	MGP_AKRJ_G0017895	protein coding gene	Chr11:423812-434888 (+)
BALB/cJ	MGP_BALBcJ_G0017899	protein coding gene	Chr11:377680-388736 (+)
C3H/HeJ	MGP_C3HHeJ_G0017712	protein coding gene	Chr11:358712-369771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018352	protein coding gene	Chr11:431797-442859 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016011	protein coding gene	Chr11:315204-326146 (+)
CAST/EiJ	MGP_CASTEiJ_G0017274	protein coding gene	Chr11:312814-324156 (+)
CBA/J	MGP_CBAJ_G0017687	protein coding gene	Chr11:596574-610662 (+)
DBA/2J	MGP_DBA2J_G0017798	protein coding gene	Chr11:324527-335588 (+)
FVB/NJ	MGP_FVBNJ_G0017789	protein coding gene	Chr11:355075-366146 (+)
LP/J	MGP_LPJ_G0017868	protein coding gene	Chr11:458296-469168 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017815	protein coding gene	Chr11:343635-354741 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018391	protein coding gene	Chr11:434342-447230 (+)
PWK/PhJ	MGP_PWKPhJ_G0017054	protein coding gene	Chr11:298861-310079 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016850	protein coding gene	Chr11:388529-399591 (+)
WSB/EiJ	MGP_WSBEiJ_G0017328	protein coding gene	Chr11:311674-322746 (+)

Human Ortholog

PLA2G3, phospholipase A2 group III

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLA2G3, phospholipase A2 group III
Synonyms

GIII-SPLA2, sPLA2-III, SPLA2III
Links

HGNC:17934

NCBI Gene ID: 50487

neXtProt AC: NX_Q9NZ20

UniProt: Q9NZ20
Chr Location

22q12.2; chr22:31134807-31140508 (-) GRCh38

MGI Vertebrate Homology

Pla2g3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLA2G3
Gene Tree

Pla2g3

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Phenotype Summary

28 phenotypes from 1 allele in 2 genetic backgrounds
5 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice have reduced male fertility with smaller litter size and decreased susceptibility to IgE antigen-induced passive systemic and cutaneous anaphylaxis due to impaired mast cell maturation, degranulation and histamine release.

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All GO Annotations

58
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pla2g3

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All Sequences

55
RefSeq

20
UniProt

4
CCDS

CCDS48740.1

Ensembl

ENSMUSG00000034579 (Evidence)
NCBI Gene

237625

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034579	Ensembl Gene Model \| MGI Sequence Detail	11067	C57BL/6J	± kb
transcript	ENSMUST00000064265	Ensembl \| MGI Sequence Detail	2566	Not Applicable
polypeptide	ENSMUSP00000068699	Ensembl \| MGI Sequence Detail	504	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012803 group 3 secretory phospholipase A2

(term hierarchy)
EC

3.1.1.4
InterPro Domains

IPR016090 Phospholipase A2 domain

IPR036444 Phospholipase A2 domain superfamily

IPR033113 Phospholipase A2, histidine active site

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:310094 Taketomi Y, et al., Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2 Impairs Mast Cell Maturation and Functions. Cells. 2021 Jul 4;10(7)

TSS for Pla2g3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100053	Chr11:3438208-3438232 (+)	-64 bp
Tssr100054	Chr11:3438275-3438287 (+)	-3 bp
Tssr100055	Chr11:3438292-3438304 (+)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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